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A rapid whole blood platelet aggregation function detection device and method

A technology of platelet aggregation and function detection, which is applied in the field of laboratory medicine, can solve problems such as inability to adapt to large-scale sample detection, inability to detect platelet function, and poor stability of test results, achieving human intervention and small influencing factors, reducing operating procedures, The effect of testing conditional criteria

Active Publication Date: 2015-11-18
SINNOWA MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods generally have poor stability of test results, large blood volume, cumbersome operations, long time-consuming, high work intensity, or high cost of testing, which are difficult to be popularized in clinic.
In addition, the common deficiency of these methods is that they cannot adapt to the detection of large batches of samples.
Due to the defects and insufficiencies of the existing detection technology, the current platelet function test cannot be widely used in medical clinics, and it may also be an important reason for the serious harm of thrombotic diseases.

Method used

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  • A rapid whole blood platelet aggregation function detection device and method
  • A rapid whole blood platelet aggregation function detection device and method
  • A rapid whole blood platelet aggregation function detection device and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 corresponds to the position of the detection tube, and a heating device 5 is arranged at the bottom of the detection cabin 1 (such as figure 1 shown);

[0072] The sample loading tray 2 is circular, and the periphery of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks 9. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a cylindrical structure (such as image 3 As shown), hanging rods 8 are set at b...

Embodiment 2

[0075] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 is corresponding to the mounting of the detection tube, and a heating device (such as figure 1 shown);

[0076] The sample loading tray 2 is circular, and the periphery of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a square column structure (such as Figure 4 As shown), hanging rods are set at both ends close to the top position, and the hangi...

Embodiment 3

[0098] A rapid detection device for platelet aggregation function of whole blood, the device includes a detection chamber 1 and a sample tray 2 in the detection chamber 1, a detection unit 3, a driving device 4 and a heating device 5; a detection chamber cover is arranged on the top of the detection chamber , the sample loading plate 2 is connected with the driving device 4, the detection device 3 is composed of a photoelectric detector and a light source, the detection device 3 corresponds to the position of the detection tube, and a heating device is arranged at the bottom of the detection cabin 1;

[0099] The sample loading tray 2 is circular, and the circumference of the sample loading tray 2 is connected to 8 detection tube racks 7 through hooks. The detection tube racks are sealed at the bottom, open at the top, and hollowed out on the side wall. The inner cavity is a square cylindrical structure (such as Figure 4 As shown), hanging rods are set at both ends close to th...

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Abstract

The invention discloses a rapid platelet aggregation function detection device and method. The device includes a detection cabin, a sample tray in the detection cabin, a detection unit, a driving device, a heating device and the like. This method uses low-speed centrifugation to settle red blood cells, white blood cells, and platelet aggregation complexes to the bottom of the detection tube, and platelet monomers that have not aggregated do not settle and remain in the supernatant (plasma), and then directly irradiate the supernatant with visible light. Visible light produces absorption and scattering. When the same volume of platelets is irradiated with a specific wavelength, the absorption and scattering of light by platelets is related to the concentration of platelets. The content of platelets in the supernatant can be detected by detecting the transmitted light signal or the intensity of scattered light when the supernatant is irradiated with a specific wavelength, and compared with the transmitted light or scattered light signal of the corresponding control tube, and calculated based on this The aggregation rate of platelets reflects the aggregation function level of sample platelets.

Description

technical field [0001] The invention relates to the field of laboratory medicine, in particular to a rapid whole blood platelet aggregation function detection device and method using whole blood as a sample. Background technique [0002] Thrombotic disease refers to the general term for various diseases such as myocardial infarction and cerebral infarction caused by blood embolism. According to the data released by international and Chinese health organizations, the death rate caused by thrombosis has long occupied the first place among all causes of death. Thrombosis has the characteristics of high mortality, high morbidity, high recurrence rate, and high disability rate. The most serious disease to human health and life. [0003] Platelets are an important component of blood coagulation and hemostasis. Long-term laboratory research and clinical practice have confirmed that: platelets are the first and key factor in thrombus formation; antiplatelet drugs are key measures f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/00G01N21/59G01N21/47
Inventor 徐新周强朱建波张陆军宋成桥
Owner SINNOWA MEDICAL SCI & TECH
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