Degradable magnesium alloy nerve conduit for nerve defect repair and preparation method of nerve conduit

Abstract

The invention discloses a degradable magnesium alloy nerve conduit for nerve defect repair and a preparation method of the nerve conduit. The nerve conduit is circular, a plurality of rows of through holes are formed in the wall of the nerve conduit, each row of through holes are distributed at equal intervals along the axial direction of the circular conduit, and adjacent rows of through holes are staggered. The preparation method of the nerve conduit includes the steps: firstly, machining a 45-degree conical surface at one end of a magnesium alloy pipe billet and extruding the magnesium alloy pipe billet to obtain a magnesium alloy middle pipe; secondly, rolling and drawing the magnesium alloy middle pipe in a multi-pass manner to obtain a capillary; thirdly, performing stress relief annealing, heat insulation, laser cutting and punching on the capillary to obtain a porous conduit; fourthly, pickling the porous conduit in an ultrasonic cleaner and performing electrochemical polishing treatment. The preparation method is simple in process, and the prepared porous degradable magnesium alloy nerve conduit for nerve defect repair is uniform in wall thickness and has a smooth surface.

Description

technical field [0001] The invention relates to the field of biological material processing, in particular to a degradable magnesium alloy nerve guide for nerve defect repair and a preparation method thereof. Background technique [0002] The repair materials for peripheral nerve defects include autologous tissues (such as nerves, blood vessels, acellular matrix, etc.), but the sources of autologous tissues are limited and will cause permanent damage to the donor site. Bridging and repairing nerve defects through catheter-based tissue-engineered artificial nerves is the most promising approach. At present, the catheters used in nerve repair are mainly concentrated in high molecular polymers and natural biomaterials. Although these materials have excellent biocompatibility, their degradation products are likely to cause inflammation in the surrounding tissues and collapse of the tube wall, resulting in poor permeability of the tube wall. , the degradation time is difficult t...

AI Technical Summary

Problems solved by technology

At present, the catheters used in nerve repair are mainly concentrated in high molecular polymers and natural biomaterials. Although these materials have excellent biocompatibility, their degradation products are likely to cause inflammation in the surrounding tissues and collapse of the tube wall, resulting in poor permeability of the tube wall. , the degradation time is difficult to precisely control, which is not conducive to the regeneration of nerve axons

Therefore, there is no ideal nerve guide material widely used clinically.

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