Application of prednisone and hydroxychloroquine to preparation of compound anti-inflammatory drug

An anti-inflammatory drug, prednisone technology, applied in the field of medicine, can solve the problems of unsatisfactory curative effect of patients, achieve the effect of enhancing anti-inflammatory effect, reducing side effects, and expanding the scope of application

Inactive Publication Date: 2014-02-26
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of slow-acting antirheumatic drugs such as methotrexate and glucocorticoids is a commonly used combination regimen, which has been widely used in clinical practice, but the curative effect on some patients is not satisfactory

Method used

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  • Application of prednisone and hydroxychloroquine to preparation of compound anti-inflammatory drug
  • Application of prednisone and hydroxychloroquine to preparation of compound anti-inflammatory drug
  • Application of prednisone and hydroxychloroquine to preparation of compound anti-inflammatory drug

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Embodiment Construction

[0024] The content of the present invention will be further described below in conjunction with the accompanying drawings.

[0025] (1) To prepare prednisone and hydroxychloroquine compound capsules and double-layer tablets, pass 10 g of prednisone, 100 g of hydroxychloroquine raw materials and various excipients through an 80-mesh sieve; prednisone and 90 g of microcrystalline cellulose (MCC) and 200g of starch, mix evenly, use 80% ethanol solution to make soft material, pass through 18 mesh sieve to make wet granules, dry at 50°C, and granulate about 300g of prednisone granules with 20 mesh sieves; mix hydroxychloroquine with 50g MCC, 150g Mix hydroxypropyl cellulose (HPMC) evenly, make a soft material with 80% ethanol solution, pass through a 18-mesh sieve to make wet granules, dry at 50°C, and granulate with a 20-mesh sieve to obtain about 300 g of hydroxychloroquine granules; The granules are film-coated with acrylic resin II, and the two kinds of granules are weighed in ...

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Abstract

The invention discloses an application of prednisone and hydroxychloroquine to the preparation of a compound anti-inflammatory drug. The total dose of prednisone is 0.05-2mg / kg, and the total dose of hydroxychloroquine is 0.83-26.64mg / kg. The prednisone for a mouse, the dose of which is equivalent to half of the normal dose of the prednisone for an adult, is unobvious in anti-inflammatory effect in a dimethylbenzene caused mouse ear swelling test, and the prednisone with the dose has an obvious anti-inflammatory effect after being used together with the hydroxychloroquine. Cell and molecular biological tests prove that IL-1beta and IL-6 transcriptions induced by LPS (Lipopolysaccharide) can be remarkably inhibited by the combination of the hydroxychloroquine and the prednisone, and the inhibiting effect is stronger than the inhibiting effect of the prednisone or the hydroxychloroquine. The invention also develops a novel compound anti-inflammatory drug and lays the foundation for reducing the side treating effect of the prednisone and widening the application range of the prednisone.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of prednisone and hydroxychloroquine in the preparation of compound anti-inflammatory drugs. Background technique [0002] Inflammation is the body's own response to infection, antigen-antibody binding in the body, and mechanical damage. Usually presents with redness, swelling, heat, pain and dysfunction. It can be infectious inflammation due to infection or non-infectious inflammation not due to infection. A moderate inflammatory response is beneficial to the human body and is an automatic defense response of the human body, while an excessive or persistent inflammatory response can cause tissue damage and induce diseases. [0003] Anti-inflammatory drugs are used to treat tissue reactions that occur after injury. There are two types of anti-inflammatory drugs: one is steroidal anti-inflammatory drugs, that is, the glucocorticoid hydrocortisone secreted by th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61P29/00A61K31/4706
Inventor 段小群徐华强陈毅飞易伟张可锋李云秋周越菡吴卫黎荣李军
Owner GUILIN MEDICAL UNIVERSITY
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