A kind of preparation method of hypotonic oral rehydration salt

Abstract

The invention discloses a preparation method of a low-permeability oral rehydration salt. The low-permeability oral rehydration salt comprises sodium chloride, potassium chloride, sodium citrate and glucosum anhydricum, wherein the granularity of the powder passing through a 100mesh sieve is greater than or equal to 95%. The preparation method is characterized by comprising the following steps: 1) respectively weighing prescription amount of sodium chloride, potassium chloride, sodium citrate and glucosum anhydricum for late use; 2) respectively taking a certain amount of one or more of glucosum anhydricum, sodium chloride, potassium chloride and sodium citrate to combine and crush in common, and filtering by the 100mesh sieve; 3) crushing the residual glucosum anhydricum and filtering by the 100mesh sieve; 4) evenly mixing the mixture in the step 2) with the glucosum anhydricum in the step 3) inside a mixer, and split charging. By adopting the preparation method, the problem that the sodium chloride, the potassium chloride and the sodium citrate are easily blocked after being crushed into fine powder is effectively solved; no agglomerate phenomenon is generated in the overall mixing process; the mixing process is quick and smooth; the mixing uniformity and the granularity achieve the requirements of Chinese pharmacopoeia 2010 version.

Description

technical field [0001] The invention relates to a preparation method of hypotonic oral rehydration salt. Background technique [0002] Oral Rehydration Salts (OralRehydrationSalts, ORS) was proposed based on some basic research results after 1964. Since the World Health Organization (WHO) recommended the use of oral rehydration salts (ORS) in the treatment of dehydration and electrolyte disturbance in diarrheal diseases, the mortality rate of diarrhea has been greatly reduced. ORS is considered to be a major contribution to medicine in the 1970s. [0003] The classic ORS recommended by WHO in 1969 had an electrolyte osmotic concentration of 220mOSM / L. The osmotic concentration of the body fluid electrolyte of the human body is about 300mOSM / L, and the osmotic concentration of the ORS electrolyte is about 2 / 3 of the body fluid, so the ORS solution is called a 2 / 3 solution. [0004] Since the original ORS design was largely aimed at correcting cholera's hydroelectric disturb...

AI Technical Summary

Problems solved by technology

Since the ingredients for the preparation of powder should be crushed into fine powder, the particle size is finer. Generally speaking, the smaller the particle size, the worse its fluidity, so the powder may agglomerate and form agglomerates during the preparation process. The phenomenon of balling makes it difficult to mix evenly, which affects the packaging of drugs, resulting in inaccurate loading and unqualified content uniformity

[0007] In addition, according to the traditional preparation method of powder, after each component is crushed and sieved separately, sodium chloride will be severely agglomerated or even hardened during the preparation process, and potassium chloride and sodium citrate will also appear to varying degrees. Agglomeration, agglomeration should not be dispersed during the mixing process, which affects the uniformity of mixing, and the uniformity of the finished product is difficult to pass

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