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Externally-applied nano silver preparation and preparation method thereof

A kind of silver and nano technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, inorganic active ingredients, etc., can solve the problems of poor microbial infection effect, irritation and pain, etc., to promote epithelial cell growth, accelerate healing, Protects the effect of tissue regeneration

Inactive Publication Date: 2014-03-12
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As time goes by, its shortcomings are gradually exposed, such as the use of patients allergic to sulfonamides, the irritation and pain of wounds, especially it can only be used to kill superficial microorganisms, and it can only be used to kill microorganisms at a deeper level. Poor infection effect, etc.

Method used

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  • Externally-applied nano silver preparation and preparation method thereof
  • Externally-applied nano silver preparation and preparation method thereof

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Embodiment Construction

[0043] The specific embodiment of the present invention and animal experiments are further described below in conjunction with the accompanying drawings.

[0044] see figure 1 , a nano-silver external preparation and a preparation method thereof of the present invention can be divided into the following steps. The following examples take the preparation of 1000 grams of nano-silver external preparation as an example.

[0045] a. Preparation of oil phase materials: Take 20 grams of lanolin alcohol, 30 grams of cetyl alcohol, 30 grams of lecithin, 30 grams of sorbitan, 20 grams of Tween-80, dimethyl p-aminobenzyl octyl 20 grams, 140 grams of mineral oil, heat and stir, after melting at 90 ° C ± 2, keep for 5 to 10 minutes;

[0046] b. Preparation of water phase materials: Take 100 grams of glycerol and add the rest of distilled water, heat and stir to 90°C±2;

[0047] c. Heat the water phase material and flow it into the emulsification neutralization tank, heat and stir, and ...

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Abstract

The invention discloses an externally-applied nano silver preparation and a preparation method thereof. The preparation comprises lanonol, cetanol, lecithin, sorbitan, Tween-80, dimethyl p-aminobenzene methyl caprylin and mineral oil which form an oil phase, glycerol and deionized water which form a water phase, as well as nano sliver particle, cerous nitrate, acetic acid, chitosan and sodium polyacrylate. According to the method disclosed by the invention, the water-phase material and the oil-phase material flow into an emulsification neutralization tank for emulsification after being heated, and nano silver master rubber, cerium preliminary liquor and chitosan are added, and finally, the externally-applied nano sliver preparation is prepared. The preparation disclosed by the invention has a bacteriostatic effect and a sterilization effect, and particularly has very obvious effects for intractable pseudomonas aeruginosa and staphylococcus aureus. Besides, the externally-applied nano silver preparation has good permeability so as to be applied to a deep wound part, has good astringency to accelerate healing of a wound surface, is free from irritability and has an effect of promoting epithelial cells to grow.

Description

technical field [0001] The invention relates to a nano-silver external preparation and a preparation method thereof, belonging to the field of chemical medical equipment manufacturing. Background technique [0002] The skin structure is composed of epidermis, dermis and subcutaneous tissue, which have protective, secretory, sensory and metabolic functions. When the surface of the human skin is attacked by various reasons, including burns, trauma, and trauma caused by microbial infection, the physical and chemical properties and tissue structure of the normal skin are destroyed, and a natural barrier is lost, and the normal surface tissue structure loses its original shape. Anti-epidemic function, the immune regulation of the human body is out of balance, prompting the accumulation and reproduction of a large number of bacteria on the wound surface, leading to primary or secondary infection, the normal surface tissue structure is difficult to restore, seriously affecti...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61P17/02A61P31/00A61P31/04A61K33/24A61K31/722
Inventor 廖鲜艳王芸王亚茜毛恺
Owner SHANGHAI UNIV
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