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Methacrylic acid-ethyl acrylate copolymer water dispersion enteric material and preparation method thereof

A technology of ethyl acrylate and methacrylic acid, which is applied in the field of methacrylic acid-ethyl acrylate copolymer aqueous dispersion enteric type and its preparation method, can solve the problems of high cost, explosiveness, three wastes and the like, and achieves low cost , Easy to form film, good plasticity

Inactive Publication Date: 2014-03-12
悦康药业集团安徽天然制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of coating with polyacrylic resin No. Ⅱ or Ⅲ products are: high cost, flammable, explosive, and three wastes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] An enteric methacrylic acid-ethyl acrylate copolymer aqueous dispersion, which is made of the following raw materials in weight ratio: methacrylic acid: 130, ethyl acrylate: 150, potassium persulfate or ammonium persulfate: 0.8, Sodium Lauryl Sulfate: 2.1, Polysorbate-80: 5, Purified Water: 650. It can be prepared by conventional polymerization process.

Embodiment 2

[0020] An enteric methacrylic acid-ethyl acrylate copolymer aqueous dispersion, which is made of the following raw materials in weight ratio: methacrylic acid: 140, ethyl acrylate: 160, potassium persulfate or ammonium persulfate: 0.8, Sodium Lauryl Sulfate: 2.5 Polysorbate-80: 7, Purified Water: 700.

[0021] Its preparation method steps are as follows:

[0022] (1) Put the potassium persulfate or ammonium persulfate solution, sodium lauryl sulfate: polysorbate-80 dissolved in purified water into the reaction tank according to the weight ratio;

[0023] (2) Stir and heat to 70°C-80°C, put methacrylic acid and ethyl acrylate into the high level tank;

[0024] (3) Add dropwise to the reaction tank under stirring, and keep the temperature of the reaction tank at 70°C-80°C during the dropping process;

[0025] (4) After dropping, keep the temperature at 70°C-80°C for 2-3 hours and react for 2-3 hours; raise the temperature to 80°C-90°C, continue the reaction for 1-2 hours, then...

Embodiment 3

[0027] An enteric-coated aqueous dispersion of methacrylic acid-ethyl acrylate copolymer, which is made of the following raw materials in the weight ratio: methacrylic acid: 140, ethyl acrylate: 160, potassium persulfate or ammonium persulfate: 0.8, Sodium Lauryl Sulfate: 2.5 Polysorbate-80: 7, Purified Water: 700.

[0028] Its preparation method steps are as follows:

[0029] (1) Put the potassium persulfate or ammonium persulfate solution dissolved in purified water, purified water, sodium lauryl sulfate: polysorbate-80 into the reaction tank according to the weight ratio;

[0030] (2) Stir and heat to 70°C-80°C, put methacrylic acid and ethyl acrylate into the high level tank;

[0031] (3) Add dropwise to the reaction tank under stirring, and keep the temperature of the reaction tank at 70°C-80°C during the dropping process;

[0032] (4) After dropping, keep the temperature at 70°C-80°C for 2-3 hours and react for 2-3 hours; raise the temperature to 80°C-90°C, continue th...

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Abstract

The invention discloses a methacrylic acid-ethyl acrylate copolymer water dispersion enteric material. The invention is characterized in that the material is prepared from the following raw materials in parts by weight: 130-140 parts of methacrylic acid, 150-160 parts of ethyl acrylate, 0.2-1.2 parts of potassium persulfate or ammonium persulfate, 2.1-4.5 parts of sodium lauryl sulfate, 5-7 parts of polysorbate and 650-700 parts of purified water. The invention also discloses a manufacturing method of the methacrylic acid-ethyl acrylate copolymer water dispersion enteric material. The pH value of the methacrylic acid-ethyl acrylate copolymer water dispersion enteric material is 2.0-3.0. The average molecular weight of the methacrylic acid-ethyl acrylate copolymer is 0.25 million or so; and the ratio of the methacrylic acid to the ethyl acrylate in the copolymer is 1:1, wherein the copolymer accounts for 28.5-31.5 wt% of the total methacrylic acid-ethyl acrylate copolymer water dispersion enteric material. The material has the advantages of favorable plasticity and the like, and can easily form a film.

Description

technical field [0001] The invention relates to the technical field of medicinal enteric coating materials, in particular to an enteric type of methacrylic acid-ethyl acrylate copolymer aqueous dispersion and a preparation method thereof. Background technique [0002] At present, the enteric coating materials for drugs used in China include polyacrylic acid resin emulsion (enteric-coated type), polyacrylic acid resin No. Ⅱ or Ⅲ. Enteric-coated resin is a polyacrylic acid resin emulsion polymerized by methacrylic acid and butyl acrylate. Because of the poor stability of the coating material, it is difficult to ensure the weight of the drug. In addition, its product pH value is above 6.5 to dissolve, so The packaged enteric-coated pharmaceutical preparations are difficult to meet the relevant regulations of the Chinese Pharmacopoeia, so it has been on the market for nearly 30 years, and the market usage is very small. At present, most domestic pharmaceutical companies sti...

Claims

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Application Information

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IPC IPC(8): C08F220/18C08F220/06A61K47/32
Inventor 李玉生李金林
Owner 悦康药业集团安徽天然制药有限公司
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