31results about How to "Good enteric solubility" patented technology

The invention provides a probiotic microcapsule taking protein aggregate-polysaccharide as a wall material and a preparation method thereof. The preparation method comprises the following steps: enabling rice bran protein to form aggregate at low pH, mixing with polysaccharide solution in a certain volume ratio of (1:1) to (10:1), adding probiotic bacterial suspension and right amount of an emulsifying agent (Tween-80) into the formed mixed solution, lightly and uniformly stirring, forming stable emulsion at the moment, adding 1% acetic acid solution into the mixed solution while stirring continuously, so that final pH of the mixed solution is 3.8-4.0, finally adding a curing agent (gallic acid) for curing a microcapsule, and then washing with distilled water, so that a probiotic microcapsule product is obtained finally. The probiotic microcapsule provided by the invention has the advantages that the aim of crosslinking can be achieved only by controlling ratio of the protein aggregate to the polysaccharide and crosslinking time, and the prepared probiotic microcapsule can improve resistance on gastric acid, can be released in intestinal tract and absorbed by human body finally and has good property.

The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.

The invention discloses a method for microencapsulating cholesterol-degrading lactic acid bacteria, which comprises the steps of the activation of the cholesterol-degrading lactic acid bacteria, the preparation of immobilized cholesterol-degrading lactic acid bacteria, the preparation of microcapsules by a W/O/W multiphase emulsion method, and freeze-drying. The cholesterol-degrading lactic acid bacteria microcapsules prepared by adopting the multiphase emulsion method (W/O/W) have the characteristics of stability, non-toxicity and the like due to the fact that wall materials thereof all belong to natural polymer materials; the release rate of the microcapsules in intestinal juice within 2h is over 87.4 percent, and the viable count can reach 7.03*109cfu/mL; the viable count can still reach 6.81*106cfu/mL after the microcapsules are placed for 3h at the temperature of 50 DEG C, and can still reach 6*108cfu/mL after the microcapsules are stored for 30d; in vitro cholesterol degradation tests, the degradation rate of cholesterol is over 36.07 percent; and the microcapsules have better acid resistance, enteric property, high temperature resistance and cholesterol degradation, and the yield is about 86.62 percent. Capsule materials and carrier materials have low cost, so the cost is reduced.

The invention relates to the technical field of strain preparation, in particular to a leuconostoc kimchii capsule capable of reducing nitrosamine in human bodies and a preparation method of the leuconostoc kimchii capsule. The method includes steps: 1) degradation nitrosamine strain screening; 2) acid-resistant bile-salt-resistant strain screening; 3) subjecting lactobacillus pentosus and lactobacillus brevis excellent in nitrosamine degradation performance, acid resistance and bile salt resistance to freeze drying, and uniformly crushing; 4) compounding the obtained lactobacillus pentosus and lactobacillus brevis according to a ratio of 10:1-1:2; 5) proportionally stirring high fructose syrup, soybean oil and bacterial powder, well mixing into a paste state, adding mixed liquid into a boiling coating machine, performing coating of enteric coatings under conditions that the material temperature is 30-45 DEG C, the spray pressure is 0.1-0.50MPa and the flow rate is 2-10g/min, drying for 2-10min before taking out, and screening whole particles through a 10-40-mesh screen. The leuconostoc kimchii capsule obtained according to the method is capable of reducing nitrosamine in human bodies and high in entric solubility.

The invention discloses a lansoprazole enteric-coated tablet and a preparation method thereof. The preparation method comprises the following steps: preparing lansoprazole and pharmaceutic adjuvants comprising starch, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, calcium hydrogen phosphate, povidone K30, sodium hydroxide, magnesium stearate and the like into a tablet core; coating the tablet core with an isolated layer, and finally coating the tablet core with an enteric-coated layer so as to obtain the lansoprazole enteric-coated tablet. According to the method, the solubility and releasing rate of the lansoprazole are effectively improved, so that the oral bioavailability of the lansoprazole is improved. The formula process for preparing the lansoprazole enteric-coated tablet is simple, convenient and stable, and is suitable for mass industrial production.

The invention relates to a probiotics microcapsule and a preparation method of probiotics microcapsule freeze-dried powder. The preparation method comprises the following steps: activating a bacterialstrain, preparing a fermented skimmed milk bacterial solution, preparing a microcapsule, freeze drying and the like. The microcapsule particles prepared in the invention are good in morphological characteristics and compact in surface, the particle size is 70 to 130 micrometers, the coating rate is greater than 85 percent, the gastric acid resistance is good, and the intestinal juice release performance, the freeze drying resistance and the storage stability are good, so that the probiotics can be protected against the adverse environment, the health effect of the probiotics in the human bodycan be improved, and the defects of the traditional embedding method are solved. The technology for preparing the probiotics microcapsule can be widely applied to the technical fields such as food, biological technology and the like.

The invention provides a process for preparing a temperature-resistant enteric coated enzyme preparation product, which is characterized by comprising the following steps of: (1) mixing liquid mannase and corn starch, polishing the mixture by using a shot blasting machine after oscillating granulation, and drying the mixture at a low temperature through fluidized bed equipment to form a granular mannan enzyme preparation; (2) preparing medicinal heat-resistant coating powder by the following components in percentage by weight: 10 to 20 percent of polyalcohol, 2 to 5 percent of sodium cellulose, 2 to 5 percent of inorganic calcium and the balance of modified starch; preparing enteric coated powder by the following components in percentage by weight: 25 to 50 percent of sodium alginate and 50 to 75 percent of modified starch; mixing the prepared heat-resistant coating powder and the prepared enteric coated powder in a ratio of 1 to 1; and (3) dissolving the mixed coating material into purified water in a ratio of 4 to 8 percent, and coating and drying the product by using boiling fluidized bed equipment to form the temperature-resistant enteric coated product. The process solves the problems of temperature resistance and acid resistance, and has the advantages of simple process, convenient operation and strong practicability.

The invention discloses a fish oil enteric coated microcapsule and a preparing method thereof. The enteric coated microcapsule is mainly prepared from raw materials of 200-400 parts of fish oil 200-400 parts of lecithin, 100-200 parts of glycerinum, 2-5 parts of natural vitamin E, 1-2 parts of lemon oil, 100-200 parts of sodium alginate and 1000-1300 parts of calcium amino acid chelate. The sodium alginate and the lecithin have an emulsifying effect, the glycerinum has an emulsification assisting effect, and the fish oil is emulsified by the sodium alginate, the lecithin and the glycerinum. When the sodium alginate substitutes with calcium ion in calcium water solution, calcium alginate which does not dissolve in water is formed to wrap the fish oil to form the enteric coated microcapsule, and then the enteric coated microcapsule is filled into a hard capsule. Thus, no fishy smell goes out the stomach reversely. Furthermore, the fish oil enteric coated microcapsule is easy to absorb, high in stability and long in valid period.

The invention relates to a lactobacillus plantarum capsule for poultry and an application thereof, and belongs to the technical field of microbial feed additives. The lactobacillus plantarum capsule consists of a wall material, lactobacillus plantarum, a freeze-drying protective additive, stachyose and toadstool enzymolysis powder, wherein the wall material consists of enzymolysis soybean protein isolate, chitosan, xanthan gum, carrageenan, glycerinum and mycose. When the substances are prepared into a mixed solution, the concentration of the enzymolysis soybean protein isolate is 7-10 percent; the concentration of the chitosan is 1-2 percent; the concentration of the xanthan gum is 1-3 percent; the concentration of the carrageenan is 0.1-0.5 percent; the concentration of the glycerinum is 0.3-1 percent; and the concentration of the mycose is 0.5-2 percent. Through adoption of the lactobacillus plantarum capsule, the gastric acid resistance of the capsule is enhanced; very high enteric solubility is achieved; the growth of pathogenic bacteria can be effectively restrained; the immunity is enhanced; the morbidity of the poultry is lowered; the breeding quality is enhanced; and the breeding benefit is increased.

The invention discloses a preparation method and application of a micro-capsule coated egg yolk antibody IgY resistant to main pathogenic bacteria of dairy cow mastitis. A compound mycoprotein antigen is prepared by selecting streptococcus agalactiae, streptococcus dysgalactiae, staphylococcus aureus and escherichia coli and is mixed with an equal quantity of freund's adjuvant to prepare a multivalence antigen immune complex, laying hens are immune by adopting repeatedly alternative immune procedures and a muscular and subcutaneous multipoint injection means, a specific yolk immunoglobulin IgY resistant to the main pathogenic bacteria of dairy cow mastitis, namely DP-BM-IgY, is separated and purified from collected egg yolk, then homogeneous emulsification is conducted on the specific yolk immunoglobulin and a sodium alginate water solution and an emulsifying agent soya bean salad oil containing span-80, the emulsified solution is dropwise added into an encystation solution prepared from CaCl2 and chitosan for coating and curing, and the coated micro-capsules can effectively protect the activity of the DP-BM-IgY and have enteric solubility. The preparation method utilizes a micro-capsule technology and selects the chitosan and sodium alginate as coating materials (natural polysaccharides), and the egg yolk antibody is internally taken and free of any toxic or side effect.

The invention belongs to the technical field of feeds, and specifically discloses a young pigeon disease prevention feed. The young pigeon disease prevention feed is prepared from a basic diet coating agent and a disease prevention additive according to a certain mass fraction by crushing, mixing and granulating, spraying and drying; the disease prevention additive is mainly prepared from Radix Codonopsis, Radix Glycyrrhizae, Artemisia annua, pine needles, Radix Puerariae, fumaric acid, citric acid, Isomalto-oligosaeeharide, mannan oligosaccharide and a probiotic compound according to a certain weight ratio, the probiotic is mainly prepared by mixing Streptococcus lactis, beer yeast, lactobacillus bifidus, Lactobacillus acidophilus and Bacillus cereus according to a certain weight ratio. The preparation method is simple and easy to implement, and can improve the preservation rate of effective components in the disease prevention feed. The young pigeon disease prevention feed prepared by the method has the characteristics of being green, safe, free of toxic and side effects, and good in control effect, can effectively improve the pigeon's resistance, thereby effectively improving the survival rate of young pigeons, and improving economic benefits of the young pigeon.

The invention belongs to the field of feed additives, and particularly relates to an intestines dissolving type aureomycin pellet premix and a preparation method thereof. The intestines dissolving type aureomycin pellet premix is prepared from the following components in weight: 65-80% of medicine-carrying pellet, 5-10% of isolation layer and 15-25% of intestines dissolving type coating layer, wherein the isolation layer is coated at the exterior; the medicine-carrying pellet consists of aureomycin hydrochloride, N-trimethyl chistan, povidone K30 and sodium carboxymethyl starch; the isolation layer consists of hydroxypropyl methyl cellulose, talcum powder and polyethylene glycol 4000; the intestines dissolving type coating layer consists of intestines dissolving type material, plasticizer and talcum powder. The intestines dissolving type aureomycin pellet premix has the advantages that the intestines dissolving characteristic is realized, the problems of instability of aureomycin in stomach liquid and easiness in hydrolysis are solved, the aureomycin is slowly released in the intestines, the bioavailability is favorably improved, the medicine carrying amount is higher, the distribution of particle size is narrower, the appearance is round and regular, and the fluidity is better.

The invention discloses a bacteriophage microcapsule and a preparation method thereof, the bacteriophage microcapsule is mainly prepared from the following components: a bacteriophage core material, a protective agent and a wall material, the wall material comprises one or more of sodium alginate, gelatin, carrageenan, maltodextrin, chitosan and hydroxymethyl cellulose; the protective agent comprises one or more of amphoteric starch, trehalose, skimmed milk, calcium carbonate, cane sugar and maltodextrin. The preparation method comprises the following steps: respectively adding a wall material and a protective agent into bacteriophage fermentation liquor in proportion, and fully and uniformly mixing to obtain bacteriophage glue liquor; extruding the bacteriophage glue solution into the curing agent solution through a hole sharpening method, and standing and curing to obtain a wet capsule; washing the wet capsules with a washing solution; and soaking the washed wet capsule in a film coating material solution for film coating treatment to obtain the bacteriophage microcapsule. The bacteriophage microcapsule has good acid resistance and storage stability and high slow release rate, and the survival rate of the bacteriophage is improved.