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31results about How to "Good enteric solubility" patented technology

Probiotic microcapsule taking protein aggregate-polysaccharide as wall material and preparation method thereof

The invention provides a probiotic microcapsule taking protein aggregate-polysaccharide as a wall material and a preparation method thereof. The preparation method comprises the following steps: enabling rice bran protein to form aggregate at low pH, mixing with polysaccharide solution in a certain volume ratio of (1:1) to (10:1), adding probiotic bacterial suspension and right amount of an emulsifying agent (Tween-80) into the formed mixed solution, lightly and uniformly stirring, forming stable emulsion at the moment, adding 1% acetic acid solution into the mixed solution while stirring continuously, so that final pH of the mixed solution is 3.8-4.0, finally adding a curing agent (gallic acid) for curing a microcapsule, and then washing with distilled water, so that a probiotic microcapsule product is obtained finally. The probiotic microcapsule provided by the invention has the advantages that the aim of crosslinking can be achieved only by controlling ratio of the protein aggregate to the polysaccharide and crosslinking time, and the prepared probiotic microcapsule can improve resistance on gastric acid, can be released in intestinal tract and absorbed by human body finally and has good property.
Owner:SHENYANG NORMAL UNIV

Preparation method for microecologics for laying hen feeds and application of microecologics

InactiveCN103518980AInhibit the growth of pathogenic bacteriaStimulate immune responseAnimal feeding stuffMethionine biosynthesisChemistry
The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.
Owner:NANJING AGRICULTURAL UNIVERSITY

Method for microencapsulating cholesterol-degrading lactic acid bacteria

The invention discloses a method for microencapsulating cholesterol-degrading lactic acid bacteria, which comprises the steps of the activation of the cholesterol-degrading lactic acid bacteria, the preparation of immobilized cholesterol-degrading lactic acid bacteria, the preparation of microcapsules by a W / O / W multiphase emulsion method, and freeze-drying. The cholesterol-degrading lactic acid bacteria microcapsules prepared by adopting the multiphase emulsion method (W / O / W) have the characteristics of stability, non-toxicity and the like due to the fact that wall materials thereof all belong to natural polymer materials; the release rate of the microcapsules in intestinal juice within 2h is over 87.4 percent, and the viable count can reach 7.03*109cfu / mL; the viable count can still reach 6.81*106cfu / mL after the microcapsules are placed for 3h at the temperature of 50 DEG C, and can still reach 6*108cfu / mL after the microcapsules are stored for 30d; in vitro cholesterol degradation tests, the degradation rate of cholesterol is over 36.07 percent; and the microcapsules have better acid resistance, enteric property, high temperature resistance and cholesterol degradation, and the yield is about 86.62 percent. Capsule materials and carrier materials have low cost, so the cost is reduced.
Owner:DALIAN POLYTECHNIC UNIVERSITY

Leuconostoc kimchii capsule capable of reducing nitrosamine in human bodies and preparation method of leuconostoc kimchii capsule

ActiveCN108077934AStrong ability to degrade nitrosaminesReduce nitrosaminesBacteriaMicroorganism based processesSolubilityFreeze-drying
The invention relates to the technical field of strain preparation, in particular to a leuconostoc kimchii capsule capable of reducing nitrosamine in human bodies and a preparation method of the leuconostoc kimchii capsule. The method includes steps: 1) degradation nitrosamine strain screening; 2) acid-resistant bile-salt-resistant strain screening; 3) subjecting lactobacillus pentosus and lactobacillus brevis excellent in nitrosamine degradation performance, acid resistance and bile salt resistance to freeze drying, and uniformly crushing; 4) compounding the obtained lactobacillus pentosus and lactobacillus brevis according to a ratio of 10:1-1:2; 5) proportionally stirring high fructose syrup, soybean oil and bacterial powder, well mixing into a paste state, adding mixed liquid into a boiling coating machine, performing coating of enteric coatings under conditions that the material temperature is 30-45 DEG C, the spray pressure is 0.1-0.50MPa and the flow rate is 2-10g / min, drying for 2-10min before taking out, and screening whole particles through a 10-40-mesh screen. The leuconostoc kimchii capsule obtained according to the method is capable of reducing nitrosamine in human bodies and high in entric solubility.
Owner:SICHUAN DONGPO CHINESE PAOCAI IND TECH RES INST

Preparation method for microecologics for laying hen feeds and application of microecologics

The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.
Owner:NANJING AGRICULTURAL UNIVERSITY

Lansoprazole enteric-coated tablet and preparation method thereof

The invention discloses a lansoprazole enteric-coated tablet and a preparation method thereof. The preparation method comprises the following steps: preparing lansoprazole and pharmaceutic adjuvants comprising starch, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, calcium hydrogen phosphate, povidone K30, sodium hydroxide, magnesium stearate and the like into a tablet core; coating the tablet core with an isolated layer, and finally coating the tablet core with an enteric-coated layer so as to obtain the lansoprazole enteric-coated tablet. According to the method, the solubility and releasing rate of the lansoprazole are effectively improved, so that the oral bioavailability of the lansoprazole is improved. The formula process for preparing the lansoprazole enteric-coated tablet is simple, convenient and stable, and is suitable for mass industrial production.
Owner:JINAN LIMIN PHARMA

Probiotics microcapsule freeze-dried powder and preparation method thereof

The invention relates to a probiotics microcapsule and a preparation method of probiotics microcapsule freeze-dried powder. The preparation method comprises the following steps: activating a bacterialstrain, preparing a fermented skimmed milk bacterial solution, preparing a microcapsule, freeze drying and the like. The microcapsule particles prepared in the invention are good in morphological characteristics and compact in surface, the particle size is 70 to 130 micrometers, the coating rate is greater than 85 percent, the gastric acid resistance is good, and the intestinal juice release performance, the freeze drying resistance and the storage stability are good, so that the probiotics can be protected against the adverse environment, the health effect of the probiotics in the human bodycan be improved, and the defects of the traditional embedding method are solved. The technology for preparing the probiotics microcapsule can be widely applied to the technical fields such as food, biological technology and the like.
Owner:INNER MONGOLIA AGRICULTURAL UNIVERSITY

Preparation method of oral animal bifidobacterium microcapsule

The invention discloses a preparation method of an oral animal bifidobacterium microcapsule, which comprises the steps of preparation of an animal bifidobacterium suspension, preparation of a water phase, preparation of an oil phase, preparation of water-in-oil emulsion, solidification, centrifugal washing and freeze-drying. A preparation technology is simple and efficient; the prepared animal bifidobacterium microcapsule can resist gastric acid and bile salt well and is good in enteric solubility; and quick reproduction can be achieved in an intestinal tract. The animal bifidobacterium microcapsule is not disintegrated in a stomach after oral administration and smoothly reaches small intestine finally; bifidobacteria are tightly combined with intestinal epithelial cells through competitive antagonism and grow and reproduce in the intestinal tract; normal physiological bacteria are directly supplemented; potential harmful pathogenic bacteria in the intestinal tract are inhibited; florabalance of the intestinal tract is adjusted; and the body immunity is improved.
Owner:JIANGSU HFQ BIO TECH CO LTD

Process for preparing temperature-resistant enteric coated enzyme preparation product

The invention provides a process for preparing a temperature-resistant enteric coated enzyme preparation product, which is characterized by comprising the following steps of: (1) mixing liquid mannase and corn starch, polishing the mixture by using a shot blasting machine after oscillating granulation, and drying the mixture at a low temperature through fluidized bed equipment to form a granular mannan enzyme preparation; (2) preparing medicinal heat-resistant coating powder by the following components in percentage by weight: 10 to 20 percent of polyalcohol, 2 to 5 percent of sodium cellulose, 2 to 5 percent of inorganic calcium and the balance of modified starch; preparing enteric coated powder by the following components in percentage by weight: 25 to 50 percent of sodium alginate and 50 to 75 percent of modified starch; mixing the prepared heat-resistant coating powder and the prepared enteric coated powder in a ratio of 1 to 1; and (3) dissolving the mixed coating material into purified water in a ratio of 4 to 8 percent, and coating and drying the product by using boiling fluidized bed equipment to form the temperature-resistant enteric coated product. The process solves the problems of temperature resistance and acid resistance, and has the advantages of simple process, convenient operation and strong practicability.
Owner:QINGDAO GENYUAN BIOLOGICAL TECH GRP

Method for preparing nutritional capsule particles by utilizing pickling water

The invention belongs to the field of food processing, and particularly relates to a method for preparing nutritional capsule particles by utilizing pickling water. The method comprises the following steps: (1) preparing pickles; (2) treating pickling water; (3) pre-treating the pickling water; (4) centrifuging the pickling water; (5) preparing high-concentration bacterial sludge; and (6) preparing capsules. According to the method, maturely fermented and savory high-quality pickles are prepared, and the capsule product with health protection, low cost, convenience in taking, long preservation period and rich lactobacillus content can be prepared by a series of treatment, and the problem of industrial pickling water recycling can be solved.
Owner:SICHUAN DONGPO CHINESE PAOCAI IND TECH RES INST

Fish oil enteric coated microcapsule and preparing method thereof

The invention discloses a fish oil enteric coated microcapsule and a preparing method thereof. The enteric coated microcapsule is mainly prepared from raw materials of 200-400 parts of fish oil 200-400 parts of lecithin, 100-200 parts of glycerinum, 2-5 parts of natural vitamin E, 1-2 parts of lemon oil, 100-200 parts of sodium alginate and 1000-1300 parts of calcium amino acid chelate. The sodium alginate and the lecithin have an emulsifying effect, the glycerinum has an emulsification assisting effect, and the fish oil is emulsified by the sodium alginate, the lecithin and the glycerinum. When the sodium alginate substitutes with calcium ion in calcium water solution, calcium alginate which does not dissolve in water is formed to wrap the fish oil to form the enteric coated microcapsule, and then the enteric coated microcapsule is filled into a hard capsule. Thus, no fishy smell goes out the stomach reversely. Furthermore, the fish oil enteric coated microcapsule is easy to absorb, high in stability and long in valid period.
Owner:山东禹王制药有限公司

Lactobacillus plantarum capsule for poultry and application thereof

The invention relates to a lactobacillus plantarum capsule for poultry and an application thereof, and belongs to the technical field of microbial feed additives. The lactobacillus plantarum capsule consists of a wall material, lactobacillus plantarum, a freeze-drying protective additive, stachyose and toadstool enzymolysis powder, wherein the wall material consists of enzymolysis soybean protein isolate, chitosan, xanthan gum, carrageenan, glycerinum and mycose. When the substances are prepared into a mixed solution, the concentration of the enzymolysis soybean protein isolate is 7-10 percent; the concentration of the chitosan is 1-2 percent; the concentration of the xanthan gum is 1-3 percent; the concentration of the carrageenan is 0.1-0.5 percent; the concentration of the glycerinum is 0.3-1 percent; and the concentration of the mycose is 0.5-2 percent. Through adoption of the lactobacillus plantarum capsule, the gastric acid resistance of the capsule is enhanced; very high enteric solubility is achieved; the growth of pathogenic bacteria can be effectively restrained; the immunity is enhanced; the morbidity of the poultry is lowered; the breeding quality is enhanced; and the breeding benefit is increased.
Owner:邵素英

Preparation method and application of micro-capsule coated egg yolk antibody IgY resistant to main pathogenic bacteria of dairy cow mastitis

The invention discloses a preparation method and application of a micro-capsule coated egg yolk antibody IgY resistant to main pathogenic bacteria of dairy cow mastitis. A compound mycoprotein antigen is prepared by selecting streptococcus agalactiae, streptococcus dysgalactiae, staphylococcus aureus and escherichia coli and is mixed with an equal quantity of freund's adjuvant to prepare a multivalence antigen immune complex, laying hens are immune by adopting repeatedly alternative immune procedures and a muscular and subcutaneous multipoint injection means, a specific yolk immunoglobulin IgY resistant to the main pathogenic bacteria of dairy cow mastitis, namely DP-BM-IgY, is separated and purified from collected egg yolk, then homogeneous emulsification is conducted on the specific yolk immunoglobulin and a sodium alginate water solution and an emulsifying agent soya bean salad oil containing span-80, the emulsified solution is dropwise added into an encystation solution prepared from CaCl2 and chitosan for coating and curing, and the coated micro-capsules can effectively protect the activity of the DP-BM-IgY and have enteric solubility. The preparation method utilizes a micro-capsule technology and selects the chitosan and sodium alginate as coating materials (natural polysaccharides), and the egg yolk antibody is internally taken and free of any toxic or side effect.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS

A kind of kimchi lactic acid bacteria capsule capable of reducing nitrosamines in human body and preparation method thereof

ActiveCN108077934BReduce nitrosaminesStrong ability to degrade nitrosaminesBacteriaMicroorganism based processesBiotechnologyHigh fructose
The invention relates to the technical field of strain preparation, in particular to a kimchi lactic acid bacteria capsule capable of reducing nitrosamines in a human body and a preparation method thereof. The method comprises the steps of: 1) screening of nitrosamine-degrading strains; 2) screening of acid-resistant and bile-salt-resistant strains; 3) obtaining Lactobacillus pentosus and short lactobacillus with strong ability to degrade nitrosamines and acid- and bile-salt resistance. The bacilli were freeze-dried and crushed evenly; 4) The obtained Lactobacillus pentosus and Lactobacillus brevis were compounded at a ratio of 10:1‑1:2; 5) The fructose syrup: soybean oil: bacteria powder were mixed in proportion Uniformly make a paste, put the above mixed solution in a boiling coating machine, coat the enteric coating under the conditions of material temperature 30-45°C, spray pressure 0.1-0.50 MPa, flow rate 2-10 g / min, and dry for 2 hours before taking out. ‑10 min, use 10‑40 mesh to screen the whole grains. The kimchi lactic acid bacteria obtained by the method can reduce nitrosamines in the human body and have good enteric solubility.
Owner:SICHUAN DONGPO CHINESE PAOCAI IND TECH RES INST

Young pigeon disease prevention feed and preparation method thereof

The invention belongs to the technical field of feeds, and specifically discloses a young pigeon disease prevention feed. The young pigeon disease prevention feed is prepared from a basic diet coating agent and a disease prevention additive according to a certain mass fraction by crushing, mixing and granulating, spraying and drying; the disease prevention additive is mainly prepared from Radix Codonopsis, Radix Glycyrrhizae, Artemisia annua, pine needles, Radix Puerariae, fumaric acid, citric acid, Isomalto-oligosaeeharide, mannan oligosaccharide and a probiotic compound according to a certain weight ratio, the probiotic is mainly prepared by mixing Streptococcus lactis, beer yeast, lactobacillus bifidus, Lactobacillus acidophilus and Bacillus cereus according to a certain weight ratio. The preparation method is simple and easy to implement, and can improve the preservation rate of effective components in the disease prevention feed. The young pigeon disease prevention feed prepared by the method has the characteristics of being green, safe, free of toxic and side effects, and good in control effect, can effectively improve the pigeon's resistance, thereby effectively improving the survival rate of young pigeons, and improving economic benefits of the young pigeon.
Owner:柳州市讯丰养殖有限公司

Intestines dissolving type aureomycin pellet premix and preparation method thereof

The invention belongs to the field of feed additives, and particularly relates to an intestines dissolving type aureomycin pellet premix and a preparation method thereof. The intestines dissolving type aureomycin pellet premix is prepared from the following components in weight: 65-80% of medicine-carrying pellet, 5-10% of isolation layer and 15-25% of intestines dissolving type coating layer, wherein the isolation layer is coated at the exterior; the medicine-carrying pellet consists of aureomycin hydrochloride, N-trimethyl chistan, povidone K30 and sodium carboxymethyl starch; the isolation layer consists of hydroxypropyl methyl cellulose, talcum powder and polyethylene glycol 4000; the intestines dissolving type coating layer consists of intestines dissolving type material, plasticizer and talcum powder. The intestines dissolving type aureomycin pellet premix has the advantages that the intestines dissolving characteristic is realized, the problems of instability of aureomycin in stomach liquid and easiness in hydrolysis are solved, the aureomycin is slowly released in the intestines, the bioavailability is favorably improved, the medicine carrying amount is higher, the distribution of particle size is narrower, the appearance is round and regular, and the fluidity is better.
Owner:GUANGZHOU CARDLO BIOCHEM TECH

Preparation method of probiotic inoculant

The invention belongs to the technical field of microbial fermentation, and particularly relates to a preparation method of a probiotic inoculant. In the invention, a high-yield gamma-aminobutyric acid inoculant is obtained from the separation and screening of yogurt and pickled vegetables. The gamma-aminobutyric acid inoculant can increase organism appetites, promote growth, regulate intestinal flora and improve the absorlption effect of alimentary canals, and has health-care effects of promoting nutrient absorption and promoting growth. In the invention, flavonoids in paper mulberry leaves and saponin substances in stauntonia chinensis are extracted, and the flavonoids and the saponin substances are important growth factors for probiotics, and thorough the cooperation with the probiotics, the flavonoids and the saponin substances can improve the survival rate of the probiotics, prolong the action time of the probiotics, lead the probiotics to reach the body in the largest quantity, and stimulate the colonization and growth of endogenous and exogenous probiotics of intestinal tracts, and can also enhance the metabolic activity of the probiotics, enhance the immune functions of theorganisms, directly antagonize pathogens, and stimulate the production of endogenous antibiotic substances of the organisms.
Owner:CHANGZHOU AMANTE CHEM CO LTD

Method for microencapsulating cholesterol-degrading lactic acid bacteria

The invention discloses a method for microencapsulating cholesterol-degrading lactic acid bacteria, which comprises the steps of the activation of the cholesterol-degrading lactic acid bacteria, the preparation of immobilized cholesterol-degrading lactic acid bacteria, the preparation of microcapsules by a W / O / W multiphase emulsion method, and freeze-drying. The cholesterol-degrading lactic acid bacteria microcapsules prepared by adopting the multiphase emulsion method (W / O / W) have the characteristics of stability, non-toxicity and the like due to the fact that wall materials thereof all belong to natural polymer materials; the release rate of the microcapsules in intestinal juice within 2h is over 87.4 percent, and the viable count can reach 7.03*109cfu / mL; the viable count can still reach 6.81*106cfu / mL after the microcapsules are placed for 3h at the temperature of 50 DEG C, and can still reach 6*108cfu / mL after the microcapsules are stored for 30d; in vitro cholesterol degradation tests, the degradation rate of cholesterol is over 36.07 percent; and the microcapsules have better acid resistance, enteric property, high temperature resistance and cholesterol degradation, and the yield is about 86.62 percent. Capsule materials and carrier materials have low cost, so the cost is reduced.
Owner:DALIAN POLYTECHNIC UNIVERSITY

Probiotic Microcapsules for Feed and Its Application

The invention provides a probiotic microcapsule and application thereof. The probiotic microcapsules are composed of wall material, plant lactobacillus, stachyose, and hickory chick enzymolysis powder. The method of coating the probiotic microcapsule product is as follows: add 3‑5% stachyose and 5‑8% hickory chick enzymatic hydrolyzed powder to the probiotic fermentation broth after fermentation and cultivation in a fermenter , and then the fermentation liquid is mixed with the wall material solution to obtain a mixed solution; the method of ultrasonic vacuum spray drying is adopted, the first level of vacuum drying, the second level of inert protective gas plus vibrating fluidized bed drying, and the probiotics are microencapsulated. The capsule of the present invention adopts modified soybean protein isolate, which has good enteric solubility. After the capsule reaches the intestinal tract, it can completely disintegrate within 1-1.5 hours to release probiotics, and rapidly proliferate to become the dominant flora, thereby inhibiting the growth of pathogenic bacteria And so on. The invention utilizes the hickory chick enzymolyzed powder, so that the product has the nutritional characteristics of the hickory chick, has good palatability, and improves the animal feeding effect.
Owner:SHANDONG JIANYUAN BIOTECHNOLOGY CO LTD

Process for preparing temperature-resistant enteric coated enzyme preparation product

The invention provides a process for preparing a temperature-resistant enteric coated enzyme preparation product, which is characterized by comprising the following steps of: (1) mixing liquid mannase and corn starch, polishing the mixture by using a shot blasting machine after oscillating granulation, and drying the mixture at a low temperature through fluidized bed equipment to form a granular mannan enzyme preparation; (2) preparing medicinal heat-resistant coating powder by the following components in percentage by weight: 10 to 20 percent of polyalcohol, 2 to 5 percent of sodium cellulose, 2 to 5 percent of inorganic calcium and the balance of modified starch; preparing enteric coated powder by the following components in percentage by weight: 25 to 50 percent of sodium alginate and 50 to 75 percent of modified starch; mixing the prepared heat-resistant coating powder and the prepared enteric coated powder in a ratio of 1 to 1; and (3) dissolving the mixed coating material into purified water in a ratio of 4 to 8 percent, and coating and drying the product by using boiling fluidized bed equipment to form the temperature-resistant enteric coated product. The process solves the problems of temperature resistance and acid resistance, and has the advantages of simple process, convenient operation and strong practicability.
Owner:QINGDAO GENYUAN BIOLOGICAL TECH GRP

Meleumycin enteric capsule and preparation method thereof

The invention relates to a meleumycin enteric capsule. The meleumycin enteric capsule comprises the following components in parts by weight: 40-45 parts of meleumycin, 30-32 parts of PVP / VA, 210-220 parts of isopropyl alcohol, 35-45 parts of talcum powder, 260-270 parts of acrylic resin, 6-8 parts of triethyl citrate, 6-8 parts of magnesium oxide, 1-4 parts of polysorbate 80, 3-5 parts of glyceryl monostearate and glyceryl distearate, 3-4 parts of hydroxy propyl methyl cellulose and 330-360 parts of purified water. The meleumycin enteric capsule is safe and effective, and has a good dissolution effect in the intestinal tract. The invention further discloses a preparation method of the meleumycin enteric capsule, the proportion of all coatings is introduced, and the process is simple and feasible and suitable for industrial production.
Owner:SUNSHINE LAKE PHARM CO LTD

Preparation method of probiotic microcapsules for feed

InactiveCN104686797BGrowth inhibitionEnhance gastric acid resistanceAccessory food factorsFluidized bed dryingVacuum drying
The invention provides a preparation method of probiotic microcapsules. The probiotic microcapsule is composed of wall material, Lactobacillus plantarum, stachyose, and Morchella enzymolysis powder. The method for coating the probiotic microcapsule product is as follows: adding 3-5% stachyose and 5-8% morel enzymolysis powder to the probiotic fermented liquid after fermentation in the fermenter , and then the fermented liquid is mixed with the wall material solution to obtain a mixed solution; the method of ultrasonic vacuum spray drying is adopted, first-level vacuum drying, second-level inert protective gas plus vibration fluidized bed drying, and microcapsule coating of probiotics. The capsule of the invention adopts modified soybean protein isolate and has good enteric solubility. After the capsule reaches the intestinal tract, it can completely disintegrate and release probiotic bacteria within 1-1.5 hours, and rapidly proliferate into a dominant flora, thereby inhibiting the growth of pathogenic bacteria. and so on. In the present invention, the enzymatic hydrolysis powder of Morchella is used, so that the product has both the nutritional properties of Morchella, has good palatability, and improves the feeding effect of animals.
Owner:黑龙江益菌生物科技有限公司

A kind of melelamycin enteric-coated capsule and its preparation method

The invention relates to a melelamycin enteric-coated capsule, which comprises the following components in parts by weight: 40-45 parts of melemycin, 30-32 parts of copovidone, 210-220 parts of isopropanol, and 35 parts of talcum powder 45 parts, 260‑270 parts of acrylic resin, 6‑8 parts of triethyl citrate, 6‑8 parts of magnesium oxide, 801‑4 parts of polysorbate, 3‑5 parts of glyceryl monostearate, hydroxypropyl 3-4 parts of methyl cellulose, 330-360 parts of purified water. The mebamycin capsule of the invention is safe and effective, and has a good dissolution effect in the intestinal tract. The invention also discloses a preparation method of the mebelamycin enteric-coated capsule, and introduces the proportion of each coating layer. The process is simple and feasible, and is suitable for industrial production.
Owner:SUNSHINE LAKE PHARM CO LTD

Preparation method of Bifidobacterium infantis microcapsules

The invention discloses a preparation method of Bifidobacterium infantis microcapsules. The microcapsules are prepared with edible gelatin and gum as microcapsule wall materials and Bifidobacterium infantis as a core material by a water phase separation method. The preparation method uses an enzyme as a cross-linking agent to prepare microcapsules, and the prepared microcapsules have strong gastric acid resistance. The preparation method disclosed by the invention has the advantages of simpleness in process, safety in administration, and on the like. The preparation method improves the utilization ratio of Bifidobacterium infantis, ensures the important roles of Bifidobacterium infantis in regulating microbial balance in infant intestinal tract, promoting infant health growth, and the like, and can effectively promote the application of Bifidobacterium infantis in infant formula milk.
Owner:黑龙江省乳品工业技术开发中心

Phage microcapsule and preparation method thereof

The invention discloses a bacteriophage microcapsule and a preparation method thereof, the bacteriophage microcapsule is mainly prepared from the following components: a bacteriophage core material, a protective agent and a wall material, the wall material comprises one or more of sodium alginate, gelatin, carrageenan, maltodextrin, chitosan and hydroxymethyl cellulose; the protective agent comprises one or more of amphoteric starch, trehalose, skimmed milk, calcium carbonate, cane sugar and maltodextrin. The preparation method comprises the following steps: respectively adding a wall material and a protective agent into bacteriophage fermentation liquor in proportion, and fully and uniformly mixing to obtain bacteriophage glue liquor; extruding the bacteriophage glue solution into the curing agent solution through a hole sharpening method, and standing and curing to obtain a wet capsule; washing the wet capsules with a washing solution; and soaking the washed wet capsule in a film coating material solution for film coating treatment to obtain the bacteriophage microcapsule. The bacteriophage microcapsule has good acid resistance and storage stability and high slow release rate, and the survival rate of the bacteriophage is improved.
Owner:QINGDAO PHAGEPHARM BIO TECH CO LTD

A kind of fish oil enteric-coated microcapsule and preparation method thereof

The invention discloses a fish oil enteric coated microcapsule and a preparing method thereof. The enteric coated microcapsule is mainly prepared from raw materials of 200-400 parts of fish oil 200-400 parts of lecithin, 100-200 parts of glycerinum, 2-5 parts of natural vitamin E, 1-2 parts of lemon oil, 100-200 parts of sodium alginate and 1000-1300 parts of calcium amino acid chelate. The sodium alginate and the lecithin have an emulsifying effect, the glycerinum has an emulsification assisting effect, and the fish oil is emulsified by the sodium alginate, the lecithin and the glycerinum. When the sodium alginate substitutes with calcium ion in calcium water solution, calcium alginate which does not dissolve in water is formed to wrap the fish oil to form the enteric coated microcapsule, and then the enteric coated microcapsule is filled into a hard capsule. Thus, no fishy smell goes out the stomach reversely. Furthermore, the fish oil enteric coated microcapsule is easy to absorb, high in stability and long in valid period.
Owner:山东禹王制药有限公司
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