31results about How to "Good enteric solubility" patented technology

The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.

The invention provides probiotic microcapsules with protein aggregate-polysaccharide as the wall material and a preparation method thereof. The preparation method is as follows: rice bran protein forms an aggregate and a polysaccharide solution at a low pH according to a certain volume ratio (1:1-10 : 1) Mix, add probiotic bacteria suspension and an appropriate amount of emulsifier (Tween-80) to the formed mixture and stir gently until a stable emulsion is formed, add 1% acetic acid under constant stirring The final pH of the solution is 3.8-4.0 in the mixed solution, and finally a curing agent (gallic acid) is added to solidify the microcapsules, and then washed with distilled water to finally obtain a probiotic microcapsule product. The present invention only needs to control the ratio of protein aggregates and polysaccharides and the crosslinking time to achieve the purpose of crosslinking. The prepared microcapsules of probiotics can improve the resistance to gastric acid, and finally release the probiotics in the intestinal tract. It is absorbed by the human body and has good storage properties.

The invention relates to a lactobacillus microcapsule, a method for preparing the same, and the use of the same. The lactobacillus microcapsule consists of an outer layer of wall material, a freeze dried protective agent and lactobacilli. The invention also provides the method for preparing the lactobacillus microcapsule and the use of the lactobacillus microcapsule as a feed additive. The lactobacillus microcapsule can effectively protect the lactobacilli in a core material, prolong the survival time of the lactobacilli at room temperature and improve the tolerance of the lactobacilli to themetal ions in the feed; in addition, the lactobacillus microcapsule has good gastric acid resistance and can disintegrate in the intestinal canal quickly to release the lactobacilli, thereby improving the utilization rate of the lactobacilli, balancing the micro-ecological environment in the intestinal canal, suppressing the growth of pathogenic bacteria, protecting the health of the intestinal canals of animals, reducing the incidence rate of the intestinal canals of the animals and the like.

The invention discloses a lansoprazole enteric-coated tablet and a preparation method thereof. The preparation method comprises the following steps: preparing lansoprazole and pharmaceutic adjuvants comprising starch, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, calcium hydrogen phosphate, povidone K30, sodium hydroxide, magnesium stearate and the like into a tablet core; coating the tablet core with an isolated layer, and finally coating the tablet core with an enteric-coated layer so as to obtain the lansoprazole enteric-coated tablet. According to the method, the solubility and releasing rate of the lansoprazole are effectively improved, so that the oral bioavailability of the lansoprazole is improved. The formula process for preparing the lansoprazole enteric-coated tablet is simple, convenient and stable, and is suitable for mass industrial production.

The invention discloses a method for microencapsulating cholesterol-degrading lactic acid bacteria, which comprises the steps of the activation of the cholesterol-degrading lactic acid bacteria, the preparation of immobilized cholesterol-degrading lactic acid bacteria, the preparation of microcapsules by a W / O / W multiphase emulsion method, and freeze-drying. The cholesterol-degrading lactic acid bacteria microcapsules prepared by adopting the multiphase emulsion method (W / O / W) have the characteristics of stability, non-toxicity and the like due to the fact that wall materials thereof all belong to natural polymer materials; the release rate of the microcapsules in intestinal juice within 2h is over 87.4 percent, and the viable count can reach 7.03*109cfu / mL; the viable count can still reach 6.81*106cfu / mL after the microcapsules are placed for 3h at the temperature of 50 DEG C, and can still reach 6*108cfu / mL after the microcapsules are stored for 30d; in vitro cholesterol degradation tests, the degradation rate of cholesterol is over 36.07 percent; and the microcapsules have better acid resistance, enteric property, high temperature resistance and cholesterol degradation, and the yield is about 86.62 percent. Capsule materials and carrier materials have low cost, so the cost is reduced.

The invention provides a probiotic microcapsule and application thereof. The probiotic microcapsules are composed of wall material, plant lactobacillus, stachyose, and hickory chick enzymolysis powder. The method of coating the probiotic microcapsule product is as follows: add 3‑5% stachyose and 5‑8% hickory chick enzymatic hydrolyzed powder to the probiotic fermentation broth after fermentation and cultivation in a fermenter , and then the fermentation liquid is mixed with the wall material solution to obtain a mixed solution; the method of ultrasonic vacuum spray drying is adopted, the first level of vacuum drying, the second level of inert protective gas plus vibrating fluidized bed drying, and the probiotics are microencapsulated. The capsule of the present invention adopts modified soybean protein isolate, which has good enteric solubility. After the capsule reaches the intestinal tract, it can completely disintegrate within 1-1.5 hours to release probiotics, and rapidly proliferate to become the dominant flora, thereby inhibiting the growth of pathogenic bacteria And so on. The invention utilizes the hickory chick enzymolyzed powder, so that the product has the nutritional characteristics of the hickory chick, has good palatability, and improves the animal feeding effect.

The invention provides a process for preparing a temperature-resistant enteric coated enzyme preparation product, which is characterized by comprising the following steps of: (1) mixing liquid mannase and corn starch, polishing the mixture by using a shot blasting machine after oscillating granulation, and drying the mixture at a low temperature through fluidized bed equipment to form a granular mannan enzyme preparation; (2) preparing medicinal heat-resistant coating powder by the following components in percentage by weight: 10 to 20 percent of polyalcohol, 2 to 5 percent of sodium cellulose, 2 to 5 percent of inorganic calcium and the balance of modified starch; preparing enteric coated powder by the following components in percentage by weight: 25 to 50 percent of sodium alginate and 50 to 75 percent of modified starch; mixing the prepared heat-resistant coating powder and the prepared enteric coated powder in a ratio of 1 to 1; and (3) dissolving the mixed coating material into purified water in a ratio of 4 to 8 percent, and coating and drying the product by using boiling fluidized bed equipment to form the temperature-resistant enteric coated product. The process solves the problems of temperature resistance and acid resistance, and has the advantages of simple process, convenient operation and strong practicability.

The invention relates to a composition for improving intrahepatic cholestasis, which comprises coated glycyrrhizinate derivatives / butyrin granules, rhubarb-rhubarb anthraquinone compound extracts, capillary extracts and selected A quercetin-like compound from quercetin or dihydroquercetin, and optionally a dry powder preparation of live probiotic bacteria. The composition of the invention has few side effects and can effectively improve the symptoms of cholestasis and the environment in the intestinal tract.

The invention provides a preparation method of probiotic microcapsules. The probiotic microcapsule is composed of wall material, Lactobacillus plantarum, stachyose, and Morchella enzymolysis powder. The method for coating the probiotic microcapsule product is as follows: adding 3-5% stachyose and 5-8% morel enzymolysis powder to the probiotic fermented liquid after fermentation in the fermenter , and then the fermented liquid is mixed with the wall material solution to obtain a mixed solution; the method of ultrasonic vacuum spray drying is adopted, first-level vacuum drying, second-level inert protective gas plus vibration fluidized bed drying, and microcapsule coating of probiotics. The capsule of the invention adopts modified soybean protein isolate and has good enteric solubility. After the capsule reaches the intestinal tract, it can completely disintegrate and release probiotic bacteria within 1-1.5 hours, and rapidly proliferate into a dominant flora, thereby inhibiting the growth of pathogenic bacteria. and so on. In the present invention, the enzymatic hydrolysis powder of Morchella is used, so that the product has both the nutritional properties of Morchella, has good palatability, and improves the feeding effect of animals.

The invention discloses a preparation method of Bifidobacterium infantis microcapsules. The microcapsules are prepared with edible gelatin and gum as microcapsule wall materials and Bifidobacterium infantis as a core material by a water phase separation method. The preparation method uses an enzyme as a cross-linking agent to prepare microcapsules, and the prepared microcapsules have strong gastric acid resistance. The preparation method disclosed by the invention has the advantages of simpleness in process, safety in administration, and on the like. The preparation method improves the utilization ratio of Bifidobacterium infantis, ensures the important roles of Bifidobacterium infantis in regulating microbial balance in infant intestinal tract, promoting infant health growth, and the like, and can effectively promote the application of Bifidobacterium infantis in infant formula milk.

The invention discloses a fish oil enteric coated microcapsule and a preparing method thereof. The enteric coated microcapsule is mainly prepared from raw materials of 200-400 parts of fish oil 200-400 parts of lecithin, 100-200 parts of glycerinum, 2-5 parts of natural vitamin E, 1-2 parts of lemon oil, 100-200 parts of sodium alginate and 1000-1300 parts of calcium amino acid chelate. The sodium alginate and the lecithin have an emulsifying effect, the glycerinum has an emulsification assisting effect, and the fish oil is emulsified by the sodium alginate, the lecithin and the glycerinum. When the sodium alginate substitutes with calcium ion in calcium water solution, calcium alginate which does not dissolve in water is formed to wrap the fish oil to form the enteric coated microcapsule, and then the enteric coated microcapsule is filled into a hard capsule. Thus, no fishy smell goes out the stomach reversely. Furthermore, the fish oil enteric coated microcapsule is easy to absorb, high in stability and long in valid period.