Fish oil enteric coated microcapsule and preparing method thereof

A technology of microcapsules and fish oil, which is applied in the direction of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of affecting product absorption and use period, affecting product absorption and use period, low stability of fish oil products, etc., to prevent blood vessels Intimal damage, good enteric properties, liver protection effect

Active Publication Date: 2016-07-13
山东禹王制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound fish oil in this invention is stomach-soluble like most fish oils in the prior art, and the fishy taste cannot be avoided, and the product stability is not high, which affects the product absorption and the period of use
[0004] To sum up, the fish oil products in the prior art are basically stomach-soluble, and the fishy smell of fish oil will come out from the stomach, especially causing troubles to the elderly, pregnant women and children
In addition, the stability of fish oil products is not high, which affects product absorption and the period of use, etc.

Method used

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  • Fish oil enteric coated microcapsule and preparing method thereof
  • Fish oil enteric coated microcapsule and preparing method thereof
  • Fish oil enteric coated microcapsule and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A fish oil enteric-coated microcapsule is made of the following raw materials in parts by mass:

[0042] 300 parts of fish oil, 300 parts of lecithin, 150 parts of glycerin, 3 parts of natural vitamin E, 1.5 parts of lemon oil, 150 parts of sodium alginate, 1200 parts of amino acid chelated calcium;

[0043] The preparation method is as follows:

[0044] (1) Mix and stir the fish oil, lecithin, glycerin, natural vitamin E and lemon oil in the prescribed amount to obtain mixed milk A;

[0045] (2) Add 15 times the mass of sodium alginate in the formula, put it in water at 45°C and stir evenly until it is completely dissolved to obtain the mixed solution B; add the mixed milk A to the mixed solution B, and keep stirring, And through the homogenizer;

[0046] (3) Amino acid chelated calcium is dissolved in the water of 25 times of quality, stirs until fully dissolving to obtain chelated calcium solution; The mixed milk that step (2) crosses homogenizer is added dropwise ...

Embodiment 2

[0048]A fish oil enteric-coated microcapsule is made of the following raw materials in parts by mass:

[0049] 200 parts of fish oil, 400 parts of lecithin, 100 parts of glycerin, 5 parts of natural vitamin E, 1 part of lemon oil, 200 parts of sodium alginate, 1000 parts of amino acid chelated calcium;

[0050] The preparation method is as follows:

[0051] (1) Mix and stir the fish oil, lecithin, glycerin, natural vitamin E and lemon oil in the prescribed amount to obtain mixed milk A;

[0052] (2) Add 13 times the mass of sodium alginate to the formula, put it in water at 40-50°C and stir evenly until it is completely dissolved to obtain the mixed solution B; add the mixed milk A to the mixed solution B, and continuously Stir and pass through a homogenizer;

[0053] (3) Amino acid chelated calcium is dissolved in the water of 20 times of quality, stirs until completely dissolving to obtain chelated calcium solution; The mixed milk that step (2) crosses homogenizer is added...

Embodiment 3

[0055] A fish oil enteric-coated microcapsule is made of the following raw materials in parts by mass:

[0056] 400 parts of fish oil, 200 parts of lecithin, 200 parts of glycerin, 2 parts of natural vitamin E, 2 parts of lemon oil, 100 parts of sodium alginate, 1300 parts of amino acid chelated calcium.

[0057] The preparation method is as follows:

[0058] (1) Mix and stir the fish oil, lecithin, glycerin, natural vitamin E and lemon oil in the prescribed amount to obtain mixed milk A;

[0059] (2) Add 17 times the mass of sodium alginate to the formula, put it in water at 40-50°C and stir evenly until it is completely dissolved to obtain the mixed solution B; add the mixed milk A to the mixed solution B, and continuously Stir and pass through a homogenizer;

[0060] (3) Amino acid chelated calcium is dissolved in the water of 30 times of quality, stirs until dissolving completely to obtain chelated calcium solution; The mixed milk that step (2) crosses the homogenizer is...

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Abstract

The invention discloses a fish oil enteric coated microcapsule and a preparing method thereof. The enteric coated microcapsule is mainly prepared from raw materials of 200-400 parts of fish oil 200-400 parts of lecithin, 100-200 parts of glycerinum, 2-5 parts of natural vitamin E, 1-2 parts of lemon oil, 100-200 parts of sodium alginate and 1000-1300 parts of calcium amino acid chelate. The sodium alginate and the lecithin have an emulsifying effect, the glycerinum has an emulsification assisting effect, and the fish oil is emulsified by the sodium alginate, the lecithin and the glycerinum. When the sodium alginate substitutes with calcium ion in calcium water solution, calcium alginate which does not dissolve in water is formed to wrap the fish oil to form the enteric coated microcapsule, and then the enteric coated microcapsule is filled into a hard capsule. Thus, no fishy smell goes out the stomach reversely. Furthermore, the fish oil enteric coated microcapsule is easy to absorb, high in stability and long in valid period.

Description

technical field [0001] The invention relates to a preparation and a preparation method thereof, in particular to a fish oil enteric-coated microcapsule and a preparation method thereof. Background technique [0002] Fish oil contains DHA and EPA. DHA plays a decisive role in the formation, growth, intelligence and function of the human brain. To a certain extent, it can improve the flexibility of the brain, inhibit the aging of the brain, and improve intelligence and brain health. EPA can inhibit liver fat and lipoprotein synthesis, promote cholesterol excretion, reduce blood triglyceride and low-density cholesterol, and increase beneficial high-density cholesterol at the same time, effectively preventing the occurrence of hyperlipidemia. Fish oil is gaining popularity due to its many health benefits. However, because fish oil has a fishy smell, and the general fish oil soft capsules are gastric soluble, there will be a slight fishy smell after eating, and the fishy taste w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61K9/50A61K47/36A61K47/24A61K47/10A61K47/22A61P25/00A61P1/16A61P3/06A61K31/685
Inventor 刘汝萃王彩华刘锡潜张建全陈立芳
Owner 山东禹王制药有限公司
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