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Intestines dissolving type aureomycin pellet premix and preparation method thereof

An enteric-coated chlortetracycline and premix technology, applied in microcapsules, pharmaceutical formulations, tetracycline active ingredients, etc., can solve the problems of instability and easy hydrolysis of chlortetracycline, and achieve long drug release time and gastric acid resistance. Strong ability and good film-forming effect

Active Publication Date: 2016-08-31
GUANGZHOU CARDLO BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of chlortetracycline pellet premix with good drug stability, high bioavailability and enteric coating characteristics, to solve the problem that chlortetracycline is unstable and easy to hydrolyze in gastric juice, prolonging the Effective action time of aureomycin in intestinal tract, improving bioavailability

Method used

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  • Intestines dissolving type aureomycin pellet premix and preparation method thereof
  • Intestines dissolving type aureomycin pellet premix and preparation method thereof
  • Intestines dissolving type aureomycin pellet premix and preparation method thereof

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Embodiment 1

[0034] The enteric-coated type chlortetracycline pellet prescription of the embodiment of the present invention 1:

[0035]

[0036] Preparation:

[0037] (1) Preparation of the coating solution for the isolation layer: take hydroxypropyl methylcellulose, add 90% ethanol solution to dissolve, and prepare a solution with a mass fraction of 5%, and then disperse talcum powder and polyethylene glycol 4000 In the solution, stir evenly to obtain the coating solution for the isolation layer;

[0038] (2) Preparation of enteric coating solution: take polyvinyl alcohol acetate phthalate, add 90% ethanol solution to dissolve, and prepare a solution with a mass fraction of 20%, then add styrene maleic acid to copolymerize Stir the compound and dibutyl sebacate until completely dissolved, then disperse the talcum powder in the solution, and stir evenly to obtain the enteric coating solution;

[0039] (3) Preparation of drug-loaded pellets: get povidone K30, add 0.5 times its weight ...

Embodiment 2

[0044] The enteric-coated type chlortetracycline pellet prescription of the embodiment of the present invention 2:

[0045]

[0046] Preparation method, with embodiment 1.

Embodiment 3

[0048] The enteric-coated type chlortetracycline pellet prescription of the embodiment of the present invention 3:

[0049]

[0050]

[0051] Preparation method, with embodiment 1.

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Abstract

The invention belongs to the field of feed additives, and particularly relates to an intestines dissolving type aureomycin pellet premix and a preparation method thereof. The intestines dissolving type aureomycin pellet premix is prepared from the following components in weight: 65-80% of medicine-carrying pellet, 5-10% of isolation layer and 15-25% of intestines dissolving type coating layer, wherein the isolation layer is coated at the exterior; the medicine-carrying pellet consists of aureomycin hydrochloride, N-trimethyl chistan, povidone K30 and sodium carboxymethyl starch; the isolation layer consists of hydroxypropyl methyl cellulose, talcum powder and polyethylene glycol 4000; the intestines dissolving type coating layer consists of intestines dissolving type material, plasticizer and talcum powder. The intestines dissolving type aureomycin pellet premix has the advantages that the intestines dissolving characteristic is realized, the problems of instability of aureomycin in stomach liquid and easiness in hydrolysis are solved, the aureomycin is slowly released in the intestines, the bioavailability is favorably improved, the medicine carrying amount is higher, the distribution of particle size is narrower, the appearance is round and regular, and the fluidity is better.

Description

technical field [0001] The invention belongs to the field of feed additives, in particular to an enteric-coated chlortetracycline pellet premix and a preparation method thereof. Background technique [0002] Chlortetracycline (Chlortetracycline), also known as chlortetracycline, referred to as CTC, is the first discovered tetracycline antibiotics. Chlortetracycline has a broad antibacterial spectrum, and has inhibitory effects on Gram-positive and negative bacteria, mycoplasma, chlamydia, spirochetes, rickettsia, amoeba, etc. The excellent antibacterial properties of chlortetracycline have attracted much attention in feed additives. my country began to use feed grade chlortetracycline as a feed additive in the 1980s. [0003] Aureomycin premix is ​​a commonly used feed additive, the main active ingredient is aureomycin calcium salt. The traditional aureomycin premix is ​​prepared by direct spray drying of the fermentation broth. In order to ensure that the aureomycin conte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/65A61K47/36A61K47/32A61K47/38A61P31/04
CPCA61K9/5026A61K9/5042A61K9/5073A61K31/65A61K47/32A61K47/36
Inventor 徐怀义
Owner GUANGZHOU CARDLO BIOCHEM TECH
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