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Composition for improving intrahepatic cholestasis and preparation method thereof

A technology of cholestasis and composition, which is applied in the field of natural medicine composition for improving intrahepatic cholestasis and its preparation, can solve the problems of poor liver and intestinal tract comprehensive conditioning effect, complex compatibility, and various components, so as to avoid gastric The effect of reducing internal loss, promoting the number of multiplication, and improving the effect of digestive tract flora

Active Publication Date: 2021-07-09
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In the prior art, although there are many natural medicine compound preparations for the treatment of cholestasis, they either have many components and are too complex in compatibility, or have large side effects, single effect, and poor comprehensive conditioning effects on the liver and intestinal tract

Method used

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  • Composition for improving intrahepatic cholestasis and preparation method thereof
  • Composition for improving intrahepatic cholestasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0065] Preparation of coated glycyrrhizinate-butyrin granules

[0066] (1) Mix 100g of glycyrrhizinic acid, 30g of arginine, and 20g of lysine in a stirred reactor, add 1L of deionized water, heat to 65°C, and stir for 4 hours; The liquid was evaporated and concentrated to about 300g and cooled to room temperature, and freeze-dried in a freeze dryer to obtain a crystalline powder containing glycyrrhizic acid amino acid salt derivatives. Chromatographic analysis of the residual amount of glycyrrhizic acid in the crystals showed that the salification rate of glycyrrhizic acid was about 94%.

[0067] (2) 10 g of glyceryl monobutyrate and 50 g of β-cyclodextrin were stirred and clathrated at room temperature to form a glyceryl butyrate embedding, and 100 g of glycyrrhizic acid amino acid salt prepared above was added and mixed uniformly to obtain a mixture; 80 g of Corn starch and 20 g of microcrystalline cellulose were stirred evenly, and a soft material was prepared with 1 wt % ...

preparation example 2

[0070] Preparation of compound natural extract granules

[0071] (1) In parts by weight, take 455 g of dried Huang Qi leaves and 242 g of rhubarb, pulverize them, heat and reflux extraction with 75% ethanol aqueous solution, repeat the extraction 3 times, extract for 1 hour each time, filter, combine the extracts, and reclaim ethanol , concentrated to 1050 mL, filtered to get the supernatant.

[0072](2) The obtained supernatant is carried out column chromatography purification with D101 type macroporous adsorption resin column in batches, and each batch of purification procedure is: wash described macroporous adsorption resin column with 3BV deionized water, discard the effluent, and then use The flow rate of 3BV / h is followed by gradient elution: first use 20% ethanol as eluent to elute 3BV, and collect to obtain eluent A; then use 75% ethanol as eluent to elute 4BV, collect to obtain Eluent B; finally use 95% ethanol as mobile phase to elute 3BV, and collect eluent C. All...

preparation example 3

[0075] 5 g of the coated glycyrrhizinate derivative / butyrin granules prepared above and the composite natural extract granules were mixed according to a weight ratio of 1:1 to obtain 10 g of the composition.

[0076] Optionally, it can be mixed with auxiliary materials according to the general method in the art and filled into capsules to make a capsule preparation.

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Abstract

The invention relates to a composition for improving intrahepatic cholestasis, which comprises coated glycyrrhizinate derivatives / butyrin granules, rhubarb-rhubarb anthraquinone compound extracts, capillary extracts and selected A quercetin-like compound from quercetin or dihydroquercetin, and optionally a dry powder preparation of live probiotic bacteria. The composition of the invention has few side effects and can effectively improve the symptoms of cholestasis and the environment in the intestinal tract.

Description

technical field [0001] The invention belongs to the technical field of natural medicine preparations, in particular to a natural medicine composition for improving intrahepatic cholestasis and a preparation method thereof. Background technique [0002] The liver is an important organ of the human body. In addition to storing glycogen, it also plays an important role in the digestive system. Bile secretion is an important function of the liver. Cholestasis occurs when bile secretion from the hepatocytes is impaired or bile flow in the bile ducts is obstructed due to various factors. Cholestasis is therefore also a condition in which the flow of bile from the liver to the duodenum is slowed or blocked. Cholestasis is one of the common liver symptoms clinically, which can be manifested clinically as jaundice, skin itching, loss of appetite, and fatigue. When the bile accumulates seriously in the bile duct, the pressure in the bile duct increases, the capillary bile duct ruptu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K47/69A61K47/32A61P1/16A61P1/00A61K35/745A61K31/704A61K31/702A61K31/352A61K31/22
CPCA61K31/22A61K31/352A61K31/702A61K31/704A61K35/745A61K36/282A61K36/52A61K36/708A61K47/32A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K47/6951A61P1/00A61P1/16A61K2300/00
Inventor 韩婕
Owner SHANDONG UNIV QILU HOSPITAL
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