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Anti-common cold capsule preparation method

A technology of capsules and relative density, which is applied in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of powder moisture absorption, high temperature, and high production costs

Inactive Publication Date: 2014-03-19
NINGXIA DUOWEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are mainly the following problems in the above-mentioned prior art: it takes about 40 hours to dry in a hot air circulation drying oven, the drying period is long, and the production cost is high; the drying temperature in a hot air circulation drying oven is 90° C. It can affect the stability of the product; the dry paste after drying in a hot air circulation drying oven is glue-like, which is difficult to close and crush, and consumes a lot of production man-hours; the powder after crushing has moisture absorption, which is not conducive to filling

Method used

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  • Anti-common cold capsule preparation method

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preparation example Construction

[0014] Please see figure 1 , which is a flow chart of the preparation method of the Kanggan capsule in a preferred embodiment, the preparation method of the Kanggan capsule comprises the following steps:

[0015] Step S300, taking honeysuckle, red peony root, and Mianma Guanzhong as ingredients according to the prescription ratio, adding water and decocting twice for 1.5 hours each time, filtering, and concentrating the filtrates to a clear paste at room temperature with a relative density of 1.18-1.22 , add ethanol to make the alcohol content of ethanol reach 50-70%, stir well and let stand for 22-24 hours to obtain the supernatant, and filter, recover ethanol from the filtrate, and concentrate to room temperature, relative density of 1.18-1.22 For the extract, for example, a double-effect concentrated evaporator can be used to recover ethanol in the filtrate and concentrate the filtrate, wherein the first-effect temperature of the double-effect concentrated evaporator is con...

Embodiment 1

[0023] Feed honeysuckle, red peony root, and Mianma Guanzhong according to the ratio of 3:3:1, add water to decoct twice, each time for 1.5 hours, filter, combine the filtrates and concentrate to a clear paste with a relative density of 1.18-1.22, add Ethanol makes the alcohol content of ethanol reach 50%. After stirring well, let it stand for 22-24 hours to obtain the supernatant, and filter it. The filtrate recovers ethanol and concentrates it to an extract with a relative density of 1.18-1.22. The extract passes through the large pores Collect the eluate after the adsorption resin is left to stand, and concentrate the eluate to a thick paste with a relative density of 1.22 to 1.24; add a predetermined amount of starch to the thick paste and mix well to obtain a mixture, and put the resulting mixture into vacuum drying Dry in the oven to obtain a honeycomb-shaped and loose dry paste. The thickness of the spreading plate is 1-3cm, the temperature is controlled at 60-80°C, the ...

Embodiment 2

[0025] Take honeysuckle, red peony root, and Mianma Guanzhong according to the ratio of 3:3:1, add water to decoct twice, each time for 1.5 hours, filter, combine the filtrates and concentrate to a clear paste with a relative density of 1.18-1.22, add Ethanol makes the alcohol content of ethanol reach 60%. After stirring well, let it stand for 22-24 hours to obtain the supernatant, and filter it. The filtrate recovers ethanol and concentrates it to an extract with a relative density of 1.18-1.22. The extract passes through the large pores The eluate is collected after the adsorption resin is left standing, and the eluate is concentrated to a thick paste with a relative density of 1.22 to 1.24; a predetermined amount of starch is added to the thick paste and mixed to obtain a mixture; the resulting mixture is placed in a vacuum Dry in a drying oven to obtain a honeycomb-shaped and loose dry paste. The thickness of the spreading plate is 1-3cm, the temperature is controlled at 60...

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Abstract

The invention relates to an anti-common cold capsule preparation method, which comprises: taking honeysuckle, red peony root and dryopteris crassirhizoma, feeding the materials according to a certain ratio, adding water, decocting twice, filtering, mixing the filtrates, concentrating to obtain a clear paste with a relative density of 1.18-1.22, adding ethanol to achieve an ethanol alcohol content of 50-70%, uniformly stirring, standing to obtain a supernatant, filtering, recovering ethanol from the filtrate, concentrating to obtain an extract with a relative density of 1.18-1.22, standing the extract through a macroporous absorption resin, collecting the eluent, concentrating to obtain a thick paste with a relative density of 1.22-1.24, adding starch to the thick paste, uniformly mixing to obtain a mixture, placing the mixture into a vacuum dry box to dry to obtain a honeycomb dry paste with loose texture, crushing the dry paste, screening to obtain coarse powder, adding magnesium stearate to the coarse powder, uniformly mixing, and filling into a hollow capsule to obtain the anti-common cold capsule. According to the present invention, stability of the product can not be affected, energy source consumption can be reduced, the dried dry paste has the loose texture so as to be easily collected, crushed and screened, and no moisture absorption phenomenon is generated when filling the coarse powder into the hollow capsule.

Description

technical field [0001] The invention relates to the technical field of preparation of Chinese patent medicines, in particular to a preparation method of Kanggan capsules. Background technique [0002] Kanggan Capsule has the effect of clearing heat and detoxifying. It is used for colds caused by exogenous wind-heat. Symptoms include fever, headache, nasal congestion, sneezing, general fatigue and soreness. The preparation method is that honeysuckle, red peony root, and Mianma Guanzhong are fed according to the prescription ratio, decocted twice for 1.5 hours each time, filtered, and the filtrates are combined and concentrated to a clear paste with a relative density of 1.18-1.22 (at room temperature). Add ethanol to make the alcohol content of ethanol reach 50-70%, stir well, let it stand for 22-24 hours, filter the supernatant, recover the ethanol from the filtrate and concentrate it to an extract with a relative density of 1.18-1.22 (at room temperature). After passing t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/48A61P11/00A61J3/07
Inventor 张毅叶新春孙艳荣
Owner NINGXIA DUOWEI PHARMA
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