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Method for synthesizing branched chain amino acid nitrate

A synthesis method and amino acid technology are applied in the field of synthesizing branched-chain amino acid nitrates, which can solve the problems that branched-chain amino acids are not easily absorbed by the body, and that branched-chain amino acids are not easy to store, package and transport, and achieve qualified product quality and simple steps. , the effect of high production efficiency

Pending Publication Date: 2014-03-26
TIANJIN TIANCHENG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention is proposed in order to overcome the disadvantages in the prior art that branched-chain amino acids are difficult to store, package and transport, and to prepare solid preparations, and that branched-chain amino acids are not easily absorbed by the body. Its purpose is to provide a branched-chain amino acid nitrate resolve resolution

Method used

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  • Method for synthesizing branched chain amino acid nitrate

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preparation example Construction

[0024] A kind of synthetic method of mixed branched-chain amino acid nitrate, comprises the steps:

[0025] a. Add nitric acid into the reaction vessel, slowly heat up to 50°C under stirring, add leucine, and keep warm for 0.5 hours to completely dissolve the leucine;

[0026] b. Heat up to 60°C again, add valine, and keep warm for 0.5 hours to dissolve all valine;

[0027] c. Then heat up to 70°C, add isoleucine, and keep warm for 0.5 hours to completely dissolve the isoleucine;

[0028] d. Filtrate the above-mentioned reacted solution, cool the filtrate to crystallize, separate the crystalline product and dry it at -0.09Mpa, 80°C to obtain a solid product of mixed branched-chain amino acid nitrate.

[0029] The molar ratio of the added amount of leucine, valine and isoleucine is 3:2:1.

[0030] The molar ratio of the added amounts of leucine, valine and isoleucine is 2:1:1.

[0031] The ratio of the moles of the added nitric acid to the sum of the moles of leucine, valine...

Embodiment 1

[0034] A kind of synthetic method of mixed branched-chain amino acid nitrate, comprises the steps:

[0035] a. Add 77.5kg of concentrated nitric acid with a mass fraction of 65% in the reaction vessel, slowly heat up to 50°C under stirring, add 52.5kg of leucine, and keep warm for 0.5 hours to completely dissolve the leucine;

[0036] b. Heating up to 60°C again, adding 23.4 kg of valine, and incubating for 0.5 hour, so that all valine was dissolved;

[0037] c. Then heat up to 70°C, add 26.2 kg of isoleucine, and keep warm for 0.5 hours to dissolve all the isoleucine;

[0038] d. Filtrate the above-mentioned reacted solution, cool the filtrate to crystallize, separate the crystalline product and dry it at -0.09Mpa, 80°C to obtain 144kg of solid product of mixed branched-chain amino acid nitrate, with a yield of 94.4%.

Embodiment 2

[0040] A kind of synthetic method of mixed branched-chain amino acid nitrate, comprises the steps:

[0041] a. Add 295kg of concentrated nitric acid with a mass fraction of 65% in the reaction vessel, slowly heat up to 50°C under stirring, add 200kg of leucine, and keep warm for 0.5 hours to completely dissolve the leucine;

[0042] b. Heating up to 60°C again, adding 89 kg of valine, and incubating for 0.5 hours, so that all valine is dissolved;

[0043] c. Heat up to 70°C again, add 100 kg of isoleucine, and keep warm for 0.5 hours to completely dissolve the isoleucine;

[0044] d. Filtrate the solution through the above reaction, the filtrate is cooled and crystallized, and the crystal product is separated and dried at -0.09Mpa and 80°C to obtain 556kg of solid product of mixed branched-chain amino acid nitrate, with a yield of 95.7%.

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Abstract

The invention discloses a method for synthesizing branched chain amino acid nitrate, and belongs to a method for synthesizing amino acid mixed nitrate. The method comprises the following steps: adding 65 percent by mass of nitric acid into a reactor; slowly heating to a certain temperature under stirring; sequentially adding leucine, valine and isoleucine, insulating and reacting for a while; filtering the solution in the reaction, cooling the filtrate to crystalize; drying the separated crystal product to obtain a solid product of the branched chain amino acid nitrate. By adopting the method for synthesizing the mixed branched chain amino acid nitrate, a pure product can be directly obtained by reactions in the method. The method is simple and practical in steps, short in time, high in production efficiency, can produce products with qualified quality and high yield, does not produce wastewater, waste gas or waste residues, and is applicable to industrial large-scale production.

Description

technical field [0001] The invention belongs to a synthesis method of amino acid mixed nitrate, in particular to a synthesis method of branched-chain amino acid nitrate. Background technique [0002] Amino acid is the basic substance that constitutes the protein required for animal nutrition. It is generally produced by people themselves or obtained through food to meet the various amino acids needed by the human body. However, in special cases, such as illness, injury or heavy exercise, in order to restore the balance of various metabolisms in the body, enhance immunity and restore physical strength as soon as possible, it is necessary to supplement various amino acids. [0003] Leucine, one of the branched-chain amino acids (BCAAs), is the amino acid most commonly found in proteins and is important for normal development in infants and children and nitrogen balance in adults. According to relevant research, leucine may play an important role in maintaining muscle by balan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P3/02A61P3/08A61P3/04
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA
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