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Preparation method and detection method of injection for treating lumbar disc herniation

A technique for lumbar intervertebral disc herniation and injection, which is applied in the field of traditional Chinese medicine and can solve the problems of narrow application surface, simple and rough extraction process and detection method, long treatment time and the like.

Inactive Publication Date: 2014-03-26
董根荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to achieve the purpose of prevention and treatment, many applicants and pharmaceutical companies have done a lot of research, and also provided some therapeutic products, such as patent number: 200810080262.8 titled "a medicinal wine for treating lumbar disc herniation" and application number 200910272688.8 The name is "an externally applied drug surface for the treatment of lumbar disc herniation", etc., but these drugs have a single dosage form, most of which are application preparations, and the application area is relatively narrow, and the extraction process and detection method of the application preparations are too simple and rough, and cannot be maximized. The maximum enrichment of active ingredients, so the effect is slow and the treatment time is long

Method used

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  • Preparation method and detection method of injection for treating lumbar disc herniation
  • Preparation method and detection method of injection for treating lumbar disc herniation
  • Preparation method and detection method of injection for treating lumbar disc herniation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Example 1: Take 18 parts of Achyranthes bidentata, 8 parts of Eucommia ulmoides, 25 parts of Sangjisheng and 18 parts of Gentiana chinensis, add 60% to 90% ethanol solution, the amount of ethanol solution is 6 to 8 times, extract by percolation, filter, and combine Alcohol liquid, recover ethanol under reduced pressure and condense into extract with relative density of 1.1-1.5; add 2-3 times of water, heat to 40-60°C and stir to dissolve, add organic solvent for extraction, recover solvent, concentrate and dry to obtain Achyranthes bidentata extract Eucommia ulmoides extract, Sangji extract and Gentiana chinensis extract; take 12 parts of Dilong, add water to decoct twice, each time add 6 to 9 times the amount of water, decoct for 2 to 3.5 hours, combine the two decoctions to concentrate into 1.1-1.5 extract; add 90%-95% ethanol to the extract, stir, precipitate to recover ethanol and concentrate, dry bath at 45-50°C, pulverize into powder to obtain Dilong extract.

Embodiment 2

[0109] Example 2: Take 25 parts of Achyranthes bidentata, 10 parts of Eucommia ulmoides, 35 parts of Sangjisheng and 25 parts of Gentiana chinensis, add water and decoct 2 to 5 times, each time for 1 to 4 hours, combine the decoction, filter, and concentrate the filtrate to 60 For clear ointment with a relative density of 1.15-1.20 °C, add an equal volume of n-butanol or sec-butanol for extraction, separate the extract, concentrate the solvent under reduced pressure to a clear ointment with a relative density of 1.15-1.20 at 60 °C, and depressurize Dry to obtain Achyranthes bidentata extract, Eucommia ulmoides extract, Sangji extract and Gentiana quinquefolium extract.

Embodiment 3

[0110] Example 3: Take 10 parts of Achyranthes bidentata, 5 parts of Eucommia ulmoides, 20 parts of Sangjisheng and 10 parts of Gentiana chinensis, add water to decoct 2 to 5 times, each time for 1 to 4 hours, combine the decoctions, filter, and concentrate the filtrate to a relative density Add ethanol to the clear ointment with a temperature of 1.15-1.20 at 60°C for precipitation and purification, filter, collect the filtrate, recover ethanol under reduced pressure to a clear ointment with a relative density of 1.15-1.20 at 60°C, dry under reduced pressure to obtain Achyranthes bidentata extract extract, Eucommia extract, Sangji extract and Gentiana extract.

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Abstract

The invention discloses a preparation method and a detection method of injection for treating lumbar disc herniation. The medicament preparation is prepared from the following components in parts by weight: 10-25 parts of the root of bidentate achyranthes, 5-10 parts of eucommia ulmoides, 10-15 parts of earthworm, 20-35 parts of loranthus parasiticus and 10-25 parts of gentiana macrophylla or extracts of the components in corresponding parts by weight. According to the preparation method, the extract of the root of bidentate achyranthes, cortex eucommiae extract, loranthus parasiticus extract, gentiana macrophylla extract and earthworm extract are combined into a novel preparation to be developed and studied, the synergic complementary effect of the five medicines in treatment on lumbar disc herniation is taken into play through matching, and a novel medicine preparation choice is provided for treatment on lumbar disc herniation. Besides, the invention further provides a preparation process of the medicament preparation. The preparation process is advanced, simple and feasible; the prepared preparation is free of toxic and side effect, and can be taken by patients for a long term. Due to adoption of the detection method disclosed by the invention, the product quality can be effectively controlled.

Description

technical field [0001] The invention relates to a preparation method and a detection method of an injection for treating lumbar intervertebral disc herniation, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Lumbar disc herniation (LDH) is a common disease in orthopedics, which can cause symptoms such as low back pain, lower limb pain, numbness, muscle weakness, and urinary and bowel disorders. Its etiology and pathogenesis, one is suffering from wind-cold, or sitting or lying on wet ground, the evil of wind-cold and water-damp impregnates the meridians, and the qi in the meridians is blocked to cause the disease; Caused by blood coagulation; the third is accompanied by deficiency of righteousness and deficiency of liver and kidney in the later stage. Lumbar intervertebral disc herniation is divided into 3 types: simple herniation type, the nucleus pulposus does not penetrate the annulus fibrosus; posterior longitudinal ligame...

Claims

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Application Information

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IPC IPC(8): A61K36/51A61K9/19A61K9/08A61P19/08G01N30/90G01N30/02A61K35/56A61K35/62
Inventor 董根荣
Owner 董根荣