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Physalis alkekengi L.var.franchetii (Mast.) Makino total saponin extract for treating cerebral ischemia and cerebral infarction
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A technology for extracting and total saponins, which is used in the field of cerebral infarction.
Inactive Publication Date: 2014-04-02
QIQIHAR UNIVERSITY
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Problems solved by technology
[0004] Before the present invention, there was no report on the pharmacological activity of total saponins of calyx clover in preventing and treating cerebral ischemia and cerebral infarction
Method used
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Embodiment 1
[0058] Example 1: Calyx clover saponins dispersible tablets
[0065] [Preparation process] Take 300g of total saponins extract of Calyx clover with a powderdiameter of 11.6μm and 190g of disintegrating agent and mix them in a mixer; add 20.8g of polyvinylpyrrolidone and 0.8g of sodium cetyl sulfosuccinate 200ml of ethanol: water (1:1) solution, make soft material, sieve and granulate; dry in a bed at 70°C for 20min; add 10g of magnesiumstearate that has passed through a 125μm aperture sieve in advance, mix; place on a tablet machine Compressed into tablets of 200 mg each.
Embodiment 2
[0066] Example 2: Lyophilized Tablets of Total Saponins of Calyx clover
[0078] [Preparation process] Make gelatin, mannitol, xanthan gum, and tartaric acid into paste with appropriate amount of water, add coloring agent and mix well; add total saponin extract of Calyx clover calyx, add appropriate amount of water to make a uniform suspension , add flavoring agent and flavoring agent, mix well, add water to the full amount, stir evenly, divide into round tanks made of polyvinyl chloride, the diameter of the round tanks is 12mm; finally freeze-dry to get the product.
[0092] [Preparation process] The above raw and auxiliary materials are crushed, passed through a No. 6 sieve, mixed, and the powder is directly compressed into tablets.
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Abstract
The invention belongs to the field of medicines, relates to application of a physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract for treating cerebral ischemia and cerebral infarction, and in particular relates to tablets, capsules, pills and other clinical common medicinal preparations and controlled-release preparations prepared by using physalis alkekengi L.var.franchetii (Mast.) Makino total saponins as a raw material. Animal experiments indicate that the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins can be used for remarkably improving behavioral symptoms caused by cerebral ischemia of a rat, reducing the size of cerebral infarction, and reducing rat encephaledema destructed by cerebral ischemia. According to the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract, the novel application of physalis alkekengi L.var.franchetii (Mast.) Makino total saponins is expanded, and a new medical resource is provided to prevention and treatment of cerebral ischemia and cerebral infarction.
Description
technical field [0001] The invention belongs to the field of medicaments, and relates to the application of total saponin extract of calyx clover to prevent and treat cerebral ischemia and cerebral infarction. Background technique [0002] Cerebral ischemia and cerebral infarction are one of the major diseases that endanger human health. The mild ones are disabled, and the severe ones are fatal, especially for the elderly. With the arrival of my country's aging society, it will seriously affect the health of the elderly in our country, even their lives, and directly or indirectly cause huge economic losses and significant social impacts. Therefore, the prevention and treatment of cerebral ischemia and cerebral infarction have become the focus of research in China and even in the world. It has been found that there are some medicines for the prevention and treatment of cerebral ischemia and cerebral infarction, but the prevention effect is better but the treatment effect is ...
Claims
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