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Cardiovascular protection medicinal composition and use thereof

A cardiovascular and composition technology, applied in the field of cardiovascular protection pharmaceutical compositions, can solve problems such as insignificant therapeutic effect, achieve the effects of excellent clinical application prospects, improve medical quality, and improve cardiovascular side effects

Active Publication Date: 2014-04-02
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that intake of antioxidants such as ascorbic acid and vitamin E can effectively prevent hypertension and coronary heart disease, but the therapeutic effect is not obvious
[0006] There is no report on the combination of angiotensin-converting enzyme inhibitors and antioxidants to reduce cardiovascular side effects caused by hemoglobin oxygen carriers

Method used

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  • Cardiovascular protection medicinal composition and use thereof
  • Cardiovascular protection medicinal composition and use thereof
  • Cardiovascular protection medicinal composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 Preparation of cardiovascular protection pharmaceutical composition of the present invention

[0048] Take 434.6 μg of captopril, 4.0 mg each of superoxide dismutase, catalase, and N-acetylcysteine, add 15 mL of normal saline, and stir with a stirring bar for 15 minutes at a speed of 600 rpm. .

Embodiment 2

[0049] Embodiment 2 Preparation of cardiovascular protection pharmaceutical composition of the present invention

[0050] Take 217.3 μg of captopril and 5.0 mg of ascorbic acid, add 15 mL of normal saline, and stir with a stirring bar for 15 minutes at a rotating speed of 600 rpm.

Embodiment 3

[0051] Embodiment 3 Preparation of cardiovascular protection pharmaceutical composition of the present invention

[0052] Take 1.5 mg of enalapril, 2.0 mg each of superoxide dismutase, catalase, and N-acetylcysteine, add 15 mL of normal saline, and stir with a stirring bar for 15 minutes at a speed of 600 rpm. .

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Abstract

The invention discloses a cardiovascular protection medicinal composition, which comprises 5 to 200 mole parts of an angiotensin-converting enzyme inhibitor and 100,000 to 600,000 mass parts of an antioxidant. The invention also discloses the use of the medicinal composition and a blood substitute. The cardiovascular protection medicinal composition can be used for effectively protecting the cardiovascular system and lowering the cardiovascular side effects of a hemoglobin-based oxygen carrier. The blood substitute has no cardiovascular side effects, and has a broad clinical application prospect, and the shortcomings of a conventional hemoglobin blood substitute are overcome.

Description

technical field [0001] The invention relates to a cardiovascular protective pharmaceutical composition and its application. Background technique [0002] With the shortage of blood resources, the limitation of storage period and the spread of infectious diseases caused by blood transfusion, it is increasingly necessary to find substitutes that can replace blood. Currently, oxygen-carrying blood substitutes mainly include fluorocarbons and hemoglobin preparations. As an important part of blood, hemoglobin (Hb) is located in red blood cells and is the main medium for the body to transport oxygen. However, pure hemoglobin solution cannot be infused directly, because hemoglobin detached from red blood cells loses the regulation of 2,3-diphosphoglycerate (2,3-DPG), and its oxygen affinity rises sharply, which cannot effectively supply oxygen to tissues. Under the action of various enzymes, free hemoglobin will quickly depolymerize into dimers and monomers, which will be excrete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P9/14A61P9/00A61P9/12A61P7/06A61K31/40A61K31/401
Inventor 李涛杨倩李茜刘进吴畏陈艳芳
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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