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Stevioside A glycoside crystal and preparation method and application thereof

A technology of stevioside and glycoside crystals, which is applied in the field of new stevioside A glycoside crystals and its preparation, and can solve problems such as unstable crystal forms

Active Publication Date: 2014-04-23
ZHUCHENG HAOTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, an article titled "Single Crystal Growth and Structure Determination of the Natural "High Potency" Sweetener Rebaudioside A" in the crystal growth and design journal "Crystal Growth & Design" reported the methanol tetrahydrate crystal form Form III, which Unstable crystal form

Method used

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  • Stevioside A glycoside crystal and preparation method and application thereof
  • Stevioside A glycoside crystal and preparation method and application thereof
  • Stevioside A glycoside crystal and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] At 60°C, dissolve excess stevioside in methanol-THF (1:1), filter, and take 1 ml of clear filtrate; place the filtrate at 5°C, let it stand for 7 days, and dry it under normal pressure at 50°C. Stevia form 7 crystals.

Embodiment 2

[0092] Dissolve excess stevioside in methanol-THF (2:1) at 60°C, filter, and take 1 ml of the clear filtrate; place the filtrate at 5°C, let it stand for 7 days, and dry it under normal pressure at 50°C. Stevia form 7 crystals.

Embodiment 3

[0094] Dissolve excess stevioside in methanol-THF (1:2) at 60°C, filter, and take 1 ml of clear filtrate; place the filtrate at 5°C, let it stand for 15 days, and dry it at 50°C under normal pressure. Stevia form 7 crystals.

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Abstract

The invention discloses a stevioside A glycoside crystal form 7, of which the structure is shown in the formula I. The XRPD (X-ray powder derivative) figure of the crystal form 7 has the following feature peaks at the angles of (2*theta-0.1) to (2*theta+0.1) degrees: 4.80 degrees, 5.48 degrees, 8.42 degrees, 9.27 degrees, 11.06 degrees, 11.27 degrees, 11.86 degrees, 12.62 degrees, 13.59 degrees, 14.20 degrees, 15.07 degrees, 15.44 degrees, 17.05 degrees, 17.72 degrees, 18.13 degrees, 18.62 degrees, 19.36 degrees, 21.26 degrees, 21.95 degrees, 22.75 degrees, 23.59 degrees, 24.14 degrees, 24.73 degrees, 25.01 degrees, 25.54 degrees, 25.98 degrees, and 26.56 degrees.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, in particular to a new stevioside A glycoside crystal and its preparation method and application. Background technique [0002] Polymorphism refers to the phenomenon that solid substances form solid states with different physical and chemical properties in two or more different spatial arrangements. In the field of pharmaceutical research, polymorphism includes multi-component crystal forms such as organic solvates and hydrates. Drug polymorphism widely exists in the drug development process and is an inherent characteristic of small organic molecules. Theoretically, small-molecule drugs can have an infinite number of crystal packing methods - polymorphic forms. Studies have shown that the number of drug polymorphic forms discovered is proportional to the time and resources invested in research. For example, Lipitor, the drug with the highest sales in the world so far, has as many as 35 crystal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H1/06A23L1/09A23L29/30
CPCA23L27/36C07H1/06C07H15/24C07H15/256A23V2002/00A23L27/33C07B2200/13
Inventor 朱理平梅雪峰江菱蕾朱冰清
Owner ZHUCHENG HAOTIAN PHARMA