Ternary molecular brush polymer with double responsivenesses to pH and temperature and nano capsule prepared from ternary molecular brush polymer

A ternary molecular brush and nanocapsule technology, which is applied in the direction of capsule delivery, microcapsules, nanocapsules, etc., can solve the problems of difficulty in preparation, lack of high specific surface area and harsh preparation conditions, and achieve application Extensive, easy to adjust and controllable size, stable structure effect

Active Publication Date: 2014-04-30
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are two bottlenecks for magnetic nanocapsules: (1) Although small-sized magnetic particles (usually less than 30nm) have superparamagnetism and high saturation magnetic susceptibility, they are difficult to prepare and require harsh preparation conditions
(2) Although large-sized magnetic microspheres (micron scale) also have high saturation magnetic susceptibility, they are too large (usually larger than 500nm) and do not have high specific surface area and aqueous solution stability
Patent CN102698282A also reports a magnetic nanocapsule with dual response to pH and temperature, but its magnetic nanoparticles are modified layer by layer with folic acid, chitosan, and PNIPAAm. It is obviously difficult to achieve the previously mentioned High magnetic susceptibility at small size
and it is very difficult to prepare

Method used

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  • Ternary molecular brush polymer with double responsivenesses to pH and temperature and nano capsule prepared from ternary molecular brush polymer
  • Ternary molecular brush polymer with double responsivenesses to pH and temperature and nano capsule prepared from ternary molecular brush polymer
  • Ternary molecular brush polymer with double responsivenesses to pH and temperature and nano capsule prepared from ternary molecular brush polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A ternary molecular brush polymer with dual responsiveness to pH and temperature, prepared by the following steps:

[0065] (1) Synthesis of functionalized polymer backbone polymers

[0066] Take 1 part of bromoisobutyrate monomethoxyethylene glycol ester initiator, 200 parts of glycidyl methacrylate (GMA), 100 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N ', N "-pentamethyldiethylenetriamine (PMDETA), carried out ATRP reaction at room temperature under the protection of nitrogen to obtain polyglycidyl methacrylate (PGMA) with a degree of polymerization (DP) of 40;

[0067] Take 100 parts of PGMA (DP=40), 100 parts of NaN 3 , 500 parts of dimethylformamide (DMF) and 1 part of AlCl 3 , and reacted at 50°C for 24 hours to obtain the functionalized polymer backbone polymer P(GMA-N 3 );

[0068] (2) Synthesis of three side chain polymers

[0069] Synthesis of hydrophilic polymer side chain polymer: take 70 parts of isopropylacrylamide (NIPAAm), 30 part...

Embodiment 2

[0078] The preparation method and raw material composition are the same as in Example 1, only the degree of polymerization of the functionalized polymer main chain and the lipophilic polymer side chain in Example 1 is adjusted, and magnetic fields, pH values ​​with different pH, temperature, and saturation magnetic susceptibility can be obtained. , Temperature triple responsive nanocapsules. The functionalized polymer main chain, the degree of polymerization of the three side chains and the properties of the nanocapsules are shown in Table 1.

[0079] Table 1: Effects of polymer main chain and lipophilic polymer side chain polymerization degree on the properties of nanocapsules of ternary molecular brushes with dual responsiveness to pH and temperature

[0080]

[0081]

[0082] It can be seen from Table 1 that by adjusting the degree of polymerization of the main chain of the functionalized polymer and the side chain of the lipophilic polymer, nanocapsules with triple r...

Embodiment 3

[0084] The preparation method and raw material composition are the same as in Example 1, only changing the composition of the lipophilic polymer side chain in Example 1, and nanocapsules with triple responsiveness to magnetic field, pH, and temperature with different pH, temperature, and saturation magnetic susceptibilities can be prepared. The composition of the lipophilic polymer side chain and the properties of the nanocapsules are shown in Table 2.

[0085] Table 2: Effect of composition of lipophilic polymer side chains on the properties of nanocapsules of ternary molecular brush polymers with dual responsiveness to pH and temperature

[0086]

[0087] It can be seen from Table 2 that by changing the composition of the lipophilic polymer side chains, nanocapsules with different performances of magnetic field, pH, and temperature triple responsiveness can be prepared.

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Abstract

The invention discloses a ternary molecular brush polymer with double responsivenesses to pH and temperature, and a nano capsule prepared from ternary molecular brush polymer with double responsivenesses to pH and temperature. The nano capsule is prepared by dispersing the ternary molecular brush polymer with double responsivenesses to pH and temperature in a two-phase system of oil and water, and performing lighting cross-linking or initiation reaction by using a photoinitiator. Difficulty that the conventional segmented copolymer is hard to effectively adjust or control the property and size of the nano capsule is solved, the size of the prepared nano capsule of the lighting cross-linking structure is easy to adjust and control, an emulsion self-assembling method adopted for preparing the nano capsule is simple to operate, the prepared hollow nano capsule is high in wrapping capability, the nano capsule disclosed by the invention is stable in structure, free of toxicity and harm due to adoption of the lighting cross-linking method, and is environment-friendly.

Description

technical field [0001] The invention belongs to the field of self-assembled polymer materials, and in particular relates to a ternary molecular brush polymer with dual responsiveness to pH and temperature, and nanocapsules prepared from the ternary molecular brush polymer with dual responsiveness to pH and temperature. Background technique [0002] Generally, the size of nanocapsules is 1-1000 nm, which is several orders of magnitude smaller than the size of microcapsules (1-2000 μm). Compared with microcapsules, nanocapsules have a higher specific surface area and exhibit special nano-effects. Due to the new characteristics produced by the special nano-effects of nanocapsules, nanocapsules can be used in high-tech fields such as drug sustained release, catalysis, bioengineering, and cosmetics. Due to the small size of nanocapsules, the synthesis is difficult. [0003] Multi-responsive nanocapsules refer to nanocapsules that can produce special changes in structural domain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08J3/28C08J3/24C08J3/07C08L87/00C08K3/22A61K9/51A61K41/00A61K47/32A61K47/34
Inventor 胡继文苗磊刘锋刘国军杨洋李妃
Owner GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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