A kind of composite collagen sponge and preparation method thereof
A technology of composite glue and sponge, which is applied in the field of composite collagen sponge and its preparation, can solve the problems of easy degradation and other problems, and achieve the effects of good air permeability, strong adhesion fastness and good elasticity
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Embodiment 1
[0030] Embodiment one: the preparation of composite collagen sponge
[0031] 1. Preparation of fish-derived collagen: all the following operations are carried out under the condition of lower than 20°C; soak the thawed fish skin raw material in 0.1mol / L NaOH solution for 24 hours to remove impurities, and then use deionized water Fully wash to neutral, soak and degrease with 10% n-butanol solvent for 24 hours, wash repeatedly with deionized water, drain, add to the high-pressure dipping tank on the instantaneous pressure-swing extraction tank, add 0.5mol / L acetic acid solution (1 : 2, W / V), inflated and pressurized 8~10kgf / cm 2 , soaked for 2 hours; put the material in the high-pressure impregnation tank into the low-pressure extraction tank above the instantaneous pressure-swing extraction tank, add 0.5mol / L acetic acid solution (1:40, W / V) and stir for 12 hours, and repeat the extraction for 2 hours. For the second time, the extraction residue was continued to be stirred an...
Embodiment 2
[0041] Embodiment two: the preparation of composite collagen sponge
[0042] 1. Preparation of fish-derived collagen: all the following operations are carried out under the condition of lower than 20°C; soak the thawed fish skin raw material in 0.1mol / L NaOH solution for 24 hours to remove impurities, and then use deionized water Fully wash to neutral, soak and degrease with 10% n-butanol solvent for 24 hours, wash repeatedly with deionized water, drain, add to the high-pressure dipping tank on the instantaneous pressure-swing extraction tank, add 0.5mol / L acetic acid solution (1 : 1, W / V), inflated and pressurized 8~10kgf / cm 2 , soak for 1 hour; put the material in the high-pressure impregnation tank into the low-pressure extraction tank above the instantaneous pressure-swing extraction tank, add 0.5mol / L acetic acid solution (1:40, W / V) and stir for 12 hours, repeat the extraction for 2 hours For the second time, the extraction residue was continued to be stirred and extrac...
Embodiment 3
[0051] Embodiment three: the preparation of composite collagen sponge:
[0052] 1) Fish-derived collagen (same as in Example 2) was dissolved in an acetic acid solution with a volume fraction of 2% to prepare a collagen solution with a mass fraction of 0.5%;
[0053] 2) Immerse the bletilla striata gum in Example 1 into distilled water, and after it has fully expanded, put it in a water bath at 50-60°C to dissolve it, add water to dilute it to make a bletilla striata gum solution with a mass fraction of 2%;
[0054] 3) Mix the collagen solution prepared above with the bletilla striata gum solution, stir evenly, then mix and add the unique extract powder (same as in Example 2), and stir evenly; the fish-derived collagen, bletilla striata gum, and unique The mass ratio of the extract is 70:20:10.
[0055] 4) Cast the mixed solution into a mold, freeze-dry to obtain a spongy material, immerse the spongy material in a cross-linking agent for cross-linking, and repeatedly wash the...
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