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Ganoderma lucidum lactone compound and pharmaceutical composition, preparation method and application thereof

A compound and semi-preparation technology, applied in the direction of drug combination, application, food preparation, etc., can solve problems such as the activity of diabetic nephropathy or chronic kidney disease that has no value therapeutic prospect

Inactive Publication Date: 2014-05-14
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no related reports on the compound of the present invention and its activity with promising therapeutic prospects for diabetic nephropathy or chronic kidney disease

Method used

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  • Ganoderma lucidum lactone compound and pharmaceutical composition, preparation method and application thereof
  • Ganoderma lucidum lactone compound and pharmaceutical composition, preparation method and application thereof
  • Ganoderma lucidum lactone compound and pharmaceutical composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Separation and purification of compound 1-3:

[0024] Chizhi (Ganoderma lucidum) 80kg, pulverized, extracted with 95% ethanol under reflux (2×360L×2h), combined the extracts and recovered the solvent under reduced pressure to obtain a crude extract, and suspended the crude extract in an appropriate amount of 1% sodium hydroxide water (PH=13), and then extracted three times with an equal volume of ethyl acetate. The alkaline water layer was neutralized with dilute hydrochloric acid, then extracted three times with equal volumes of ethyl acetate, the combined extracts were concentrated under reduced pressure to obtain 1.1 kg of ethyl acetate extract (mainly phenolic substances). The phenolic substance was subjected to silica gel column chromatography (silica gel 200-300 mesh, 7kg), chloroform-methanol system gradient elution (99:1, 98:2, 97:3, 96:4, 95:5, 94:6 , 93:7, 92:8, 90:10, 85:15, 80:20, 50:50), each solvent gradient is 1.5 times the column volume, collected accor...

Embodiment 2

[0035] Any one of the compounds in Example 1 can be made into an injection after adding water for injection according to the conventional method, finely filtering, potting and sterilizing.

Embodiment 3

[0037] Any one of the compounds in Example 1 was dissolved in sterile water for injection, filtered through a sterile funnel, subpackaged, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

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PUM

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Abstract

The invention provides six novel terpene compounds obtained by purifying traditional Chinese medicine ganoderma lucidum, a pharmaceutical compound using six novel terpene compounds as active ingredients, a preparation method of the novel terpene compounds and application of the novel terpene compounds in the preparation process of pharmaceuticals and health-care foods for treating diabetic nephropathy or chronic kidney diseases. The compound has the remarkable inhabitation effect on rat glomerular cell strain secretion IL-6 induced by high glucose, Fibronectin and IV collagen and active oxygen effect. The compound has application prospect in preparation of the pharmaceuticals for treating diabetic nephropathy or chronic kidney diseases.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, in particular, it relates to ganoderma heteroterpene derivatives with novel structure in ganoderma lucidum, their pharmaceutical compositions, their preparation methods, and their use in the preparation of medicines or health food for treating diabetic nephropathy or chronic kidney disease Applications. Background technique: [0002] The hazards, pathological mechanisms and drug research methods and principles of diabetic nephropathy or chronic kidney disease are clearly described by the applicant in the published patent publication number: CN102153630A. As we all know, changes in modern diet and lifestyle, coupled with environmental pollution, drug abuse and other factors, have led to frequent and high incidences of diabetic complications and chronic kidney diseases such as renal fibrosis worldwide. However, there is still a lack of clinically effective drugs for these diseases. [0003] Mod...

Claims

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Application Information

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IPC IPC(8): C07D307/93A61K31/365A61P13/12A61P3/10A23L1/29A23L33/00
CPCA23L33/10A23V2002/00C07D307/93A23V2250/208A23V2200/328A23V2200/30
Inventor 程永现晏永明王心龙曾琳洪苗金华方萍
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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