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Application of 3', 4'-dihydroxyacetophenone in phellinus igniarius to resisting H5N1 avian influenza virus

A technology of dihydroxyacetophenone and Phylophora spp., applied in the direction of antiviral agents, separation/purification of carbonyl compounds, active ingredients of ketones, etc., to achieve the effect of mature and clear technical route and clear structure

Inactive Publication Date: 2014-05-28
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The antibacterial activity of 3',4'-dihydroxyacetophenone has been confirmed, so far, no reports of anti-influenza virus activity have been reported

Method used

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  • Application of 3', 4'-dihydroxyacetophenone in phellinus igniarius to resisting H5N1 avian influenza virus
  • Application of 3', 4'-dihydroxyacetophenone in phellinus igniarius to resisting H5N1 avian influenza virus

Examples

Experimental program
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Effect test

example 1

[0037] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0038] (1) The fermentation medium formula is in grams / 100 milliliters:

[0039] Corn Starch 1% Glucose 1%

[0040] Peptone 0.1% Yeast Extract 0.1%

[0041] Magnesium sulfate 0.1% Potassium dihydrogen phosphate 0.01%

[0042] (2) Inoculate the Phyloporus spp. strains into the Erlenmeyer flask with the liquid medium in a conventional method, with a temperature of 25° C., a shaking flask rotation speed of 110 r / min, and pH 7 conditions, and vibrate for 7 days; cultivate When the pH value drops to 3, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, stir at a temperature of 25°C, a fermenter pressure of 0.1 kg / cm2, a pH of 3, and an air flow of 0.5-1.1vvm. Under the condition of a speed of 100 r / min, after culturing for 7 days, the crude extract of Pheronotus can be prepared by using the whole liquid fermented with the mycelia of Ph.

[0043] (3) Take ...

example 2

[0054] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0055] (1) The fermentation medium formula is in grams / 100 milliliters:

[0056] Corn Starch 3% Glucose 2%

[0057] Peptone 0.5% Yeast Extract 0.5%

[0058] Magnesium sulfate 0.5% Potassium dihydrogen phosphate 0.05%

[0059] (2) Inoculate the Phylophorus spp. strain into the Erlenmeyer flask with liquid medium in a conventional way, with a temperature of 30° C., a shaker flask rotation speed of 180 r / min, and pH 6 conditions, and vibrate for 15 days; during the cultivation When the pH value drops to 2.5, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 30°C, a fermenter pressure of 0.2 kg / cm2, pH 3, an air flow of 0.5-1.1vvm, and a stirring speed Under the condition of 180 rev / min, after culturing for 15 days, the crude extract of Pheronotus can be prepared by using the fermented whole solution of Phyloporea mycelium.

[0060...

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Abstract

The invention discloses 3',4'-dihydroxyacetophenone with an avian influenza-resisting activity, which is separated from fermentation broth and fruiting bodies of phellinus igniarius (LexFr) Quel (phellinus linteus (BerketCurt) Teng, phellinus baumii and phellinus hartigii (AlleschetSchnabl) Imaz). The invention firstly discloses a new activity of 3',4'-dihydroxyacetophenone and proves that the 3',4'-dihydroxyacetophenone has an avian influenza-resisting action. Compared with the application of a general compound, the method has the advantages that the special new activity of 3',4'-dihydroxyacetophenone is found, and the 3',4'-dihydroxyacetophenone has the action of resisting the avian influenza virus.

Description

technical field [0001] The present invention relates to a method for extracting and preparing active substances in Phylopora spp. which is resistant to avian influenza virus H5N1, especially the S. General Microorganism Center of the Preservation Management Committee", the deposit number is CGMCC No.8108, the biological sample classification name is Phellinus igniarius, and the deposit address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences . Background technique [0002] Pyrocarpus, fruiting body sessile, cap flat hemispherical or horseshoe-shaped, 2-12*3-21 cm, 1.5-10 cm thick, woody, light liver brown to dark gray or black, often cracked when old, No cortex, with fine hairs at the beginning, then become glabrous, with concentric ring ribs, blunt edges, dark cinnamon to light brown, no hymenium on the lower side. The flesh is dark brown, hard, woody, with tubes and flesh Nearly the same color, multi-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P31/16C07C49/825C07C45/79
Inventor 赵晨宋爱荣孔超黄芳梁大勇
Owner QINGDAO AGRI UNIV
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