Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure

An immunoregulatory protein and technology for chronic heart failure, applied in the field of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) in the preparation of drugs for the treatment of chronic heart failure, which can solve problems such as different clinical effects

Inactive Publication Date: 2015-04-29
张喜田 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3) β-receptor blockers, β-receptor blockers treat the pathophysiological basis of CHF - reduce myocardial oxygen consumption and improve cardiac function: However, different β-receptor blockers may have different effects on heart failure patients clinical effect
Receptor blockers are not indicated for acute heart failure and should only be used in stable conditions

Method used

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  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure
  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure
  • Application of recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the establishment of heart failure animal model

[0037] 1.1 Experimental method:

[0038] 1.1.1 Experimental materials and reagents

[0039] rLZ-8, doxorubicin hydrochloride, normal saline, disposable 1mL syringe, Shengmai injection, rat feed, litter.

[0040] 1.1.2 Instruments and equipment

[0041] Incandescent lamp, rat breeding cage, electronic balance, 4°C refrigerator, two-person ultra-clean workbench, ordinary optical inverted microscope.

[0042] 1.1.3 Experimental animals

[0043] Wistar rats, female, weighing 200-240 g, were provided by the Experimental Animal Center of Jilin University (Certificate No.: Yidongzi No. 10-5112).

[0044] 1.2 Establishment of rat heart failure model

[0045] Choose healthy and flexible Wistar rats, female, weighing 200-240g, SPF grade, refer to Teraoka's method, and give doxorubicin hydrochloride (diluted with normal saline) intraperitoneally to the rats in all groups except the blank group, the injection do...

Embodiment 2

[0046] Example 2: Therapeutic effect of rLZ-8 on rat chronic heart failure model

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Abstract

The invention relates to an application of a recombinant ganoderma lucidum immunoregulatory protein (rLZ-8) in preparation of medicines for treating chronic cardiac failure. According to the invention, a rat cardiac failure model is established by intraperitoneal injection of adriamycin amycin (ADR) to study the curative effect of rLZ-8 to chronic cardiac failure. Experimental research results show that rLZ-8 can remarkably improve the cardiac function of the rat cardiac failure model, reduce the rate of myocardial apoptosis, reduce expression of relevant apoptin in myocardial cells (caspase3 and caspase9) and increase the survival rate of rats with chronic heart failure.

Description

Technical field [0001] The invention involves the application of reorganization of Ganoderma lucidum immune regulatory protein (RLZ-8) in the application of the treatment of chronic heart failure drugs, which specifically involves the establishment of the chronic heart failure model of rats, the design of the treatment procedure, and the statistical analysis of the treatment results.The detection of cells and related proteins focuses on the application of reorganizing Ganoderma lucidum immunomically regulating proteins in the treatment of chronic heart failure models of rats. Background technique [0002] Chronic heart failure (CHF) is the most common form in heart failure. It is the end of the development of multiple cardiovascular diseases such as coronary heart disease, cardiomyopathy, hypertension, and heart valve disease. It is also the most important cause of death.With the aging population and the improvement of the diagnosis and treatment system of acute myocardial infarc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61P9/04
CPCA61K36/074A61K38/168A61P9/04
Inventor 孙非梁重阳张喜田
Owner 张喜田
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