Method for extraction separation of bergenin from Rodgersia podophylla

Abstract

The invention relates to a method for extraction separation of bergenin from Rodgersia podophylla. Specifically, the steps includes: (1) sending the dry powder of Rodgersia podophylla raw material into a subcritical ultrasonic extractor to undergo ultrasonic countercurrent extraction, conducting filtration and separation, and concentrating the ethanol-containing extracted solution by a concentration evaporator to obtain an extract thick paste, and then moving to the crystallization section; (2) subjecting the waste residue obtained by extraction and filtering to heating, vacuum pumping and desolventizing in an extraction device to obtain a by-product; (3) recycling the solvents obtained by evaporation desolventizing; (4) recovering the steam condensate and returning it to a boiler plant for recycling; and (5) adding water into the extract thick paste to undergo dissolution, adding a crystallization promoter to obtain a crystallized product, i.e. a bergenin crude product, then employing 95% ethanol to perform heating dissolving, carrying out activated carbon decolorization, subjecting the filtrate to concentration under a reduced pressure to a thick state, conducting standing crystallization, and performing centrifugal filtration the next day, thus obtaining a crystallized substance, i.e. a bergenin fine product. The method provided by the invention adopts a subcritical ultrasonic extraction technology and is carried out at 40-50DEG C, the raw material fineness requirement is loosened, the operation is easy to control, crystallization is thorough, and the product yield is high.

Description

technical field [0001] The invention relates to a production method for extracting and separating saxifrage from Cauliflower sp., belonging to the technical field of medicine extraction. Background technique [0002] In the prior art, after drying and pulverizing the slices of the raw material of the ghost lamp, extract them with 90% ethanol under hot reflux, filter the plate and frame, concentrate the filtrate under reduced pressure until it has no alcohol smell, and undergo acid-base adjustment, crystallization, centrifugal filtration, and the crystallization That is the crude product of saxifrage, which is then dissolved in 95% ethanol, decolorized by activated carbon, and the filtrate is concentrated under reduced pressure to a thick state, and left to crystallize to obtain the fine product of saxifrage. [0003] The prior art method has the following disadvantages: (1) the production must use 90% and above ethanol, otherwise the extract will have a lot of water-soluble ...

AI Technical Summary

Problems solved by technology

[0003] The prior art method has the following disadvantages: (1) the production must use 90% and above ethanol, otherwise the extract will have a lot of water-soluble impurities, and the concentrated solution will not be able to separate out crystallization. , so that the loss of ethanol is greatly increased, and the production cost is greatly increased

(2) The extraction temperature must be kept above 85°C, otherwise the extraction rate will be greatly reduced, which will cause energy waste in production

(3) The crushing of raw materials should not be too fine, it should be 0.5 ~ 1.0cm, otherwise it will be difficult for the liquid to flow out during extraction and forced circulation, which will greatly reduce the extraction rate

(4) The acid-base adjustment treatment crystallization operation is not easy to control, often resulting in incomplete crystallization and low product yield