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A kind of tablet containing moxonidine hydrochloride and preparation method thereof

A technology for moxonidine hydrochloride and tablets, which is applied in the field of tablets containing moxonidine hydrochloride and its preparation, can solve the problems of large differences in drug content in granules, increased drug viscosity, and poor fluidity, and achieve fewer types of excipients and simplified Preparation process, the effect of reducing production cost

Active Publication Date: 2015-12-30
金洪涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN102100673A uses the freeze-drying method to uniformly disperse the main drug in a certain carrier, and then uses the method of direct tableting of the powder, which solves the problem of low content uniformity when the preparation with low drug loading is directly compressed into tablets, but it becomes loose after freeze-drying , poor fluidity, easy to absorb moisture, obviously not suitable for domestic production requirements for tablets
It has been reported in the literature that dissolving the drug in ethanol and other solvents and adding it can improve the mixing degree to a certain extent, but during the drying process, with the volatilization of ethanol and other solvents, the drug will gradually migrate, resulting in large differences in drug content in the particles.
In addition, although the method of jet crushing the drug can increase the surface area of ​​the drug, it will also increase the viscosity of the drug, making it more difficult to mix the drug

Method used

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  • A kind of tablet containing moxonidine hydrochloride and preparation method thereof

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Effect test

Embodiment 1

[0025] Moxonidine Hydrochloride 2g

[0026] Polyethylene glycol 4000 51g

[0027] Lactose 500g

[0028] Sodium carboxymethyl starch 5g

[0029] Preparation Process:

[0030] Heat polyethylene glycol 4000 to 60°C, melt, add moxonidine hydrochloride to the melt, stir to dissolve, add the melt to the mixed powder of lactose and sodium carboxymethyl starch, granulate, granulate 18 mesh sieve, pressed into tablets.

Embodiment 2

[0032] Moxonidine Hydrochloride 2g

[0033] Polyethylene glycol 600060g

[0034] Microcrystalline Cellulose 500g

[0035] Crospovidone 6g

[0036] Preparation Process:

[0037] Heat polyethylene glycol 6000 to 70°C, melt, add moxonidine hydrochloride into the molten liquid, stir to dissolve, add the molten liquid to the mixed powder of microcrystalline cellulose and crospovidone, and granulate , the particles are passed through a 20-mesh sieve, and pressed into tablets.

Embodiment 3

[0039] Moxonidine Hydrochloride 2g

[0040] Polyethylene glycol 4000 20g

[0041] Polyethylene glycol 6000 40g

[0042] Microcrystalline Cellulose 500g

[0043] Crospovidone 6g

[0044] Preparation Process:

[0045] Heat polyethylene glycol 4000 and polyethylene glycol 6000 to 70°C, melt, add moxonidine hydrochloride into the melt, stir to dissolve, add the melt to the mixture of microcrystalline cellulose and crospovidone Mix the powder, granulate, pass the granules through a 20-mesh sieve, and compress into tablets.

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Abstract

The invention discloses a tablet containing moxonidine hydrochloride and a preparation method thereof. The tablet uses a solution of moxonidine hydrochloride dissolved in polyethylene glycol melt as a binder, and pharmaceutically acceptable auxiliary materials Granulated, tablet derived. On the premise of ensuring good drug mixing uniformity, the tablet of the invention unexpectedly improves the dissolution rate, and at the same time does not need to add a lubricant, simplifies the production process, and reduces the production cost.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular relates to a solid oral preparation of moxonidine hydrochloride, in particular to a tablet containing moxonidine hydrochloride and a preparation method thereof. Background technique [0002] Moxonidine hydrochloride (moxonidine) is a second-generation central antihypertensive drug, and its antihypertensive effect has been confirmed, and it also shows good hemodynamic effects. Because of its high selectivity to imidazoline I1 receptors and its weak effect on α2 receptors, moxonidine has mild antihypertensive effect, and its side effects are very mild; there are few adverse reactions, no drowsiness, no bradycardia and arrest. Drug rebound phenomenon. Compared with clonidine, the first-generation central antihypertensive drug, its tolerance is higher, and moxonidine has a smaller and shorter duration of slowing effect on heart rate in spontaneously hypertensive rat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/34A61K31/506A61P9/12
Inventor 逄增艳殷蓓蓓李云
Owner 金洪涛
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