Method for preparing diphenyl ketone compound

A technology for benzophenones and compounds is applied in the field of preparing benzophenone compounds, which can solve the problems of low catalyst stability, cumbersome preparation process, low catalyst activity, etc., and achieves broad commercial application value, simple preparation and selection. high sex effect

Inactive Publication Date: 2014-06-18
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although great progress has been made in the research on catalysts for the preparation of benzophenone compounds, there are still problems in these processes, such as low catalyst activity, cumbersome preparation process, or the need for strong oxidants and by-products.
In addition, problems such as low stability of the catalyst also limit its use.

Method used

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  • Method for preparing diphenyl ketone compound
  • Method for preparing diphenyl ketone compound
  • Method for preparing diphenyl ketone compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]In a 250ml round bottom flask, add 1mmol of substrate, 1.2g of 30% hydrogen peroxide, and weigh 0.3g of 5wt% Pt / MoO 3 The reaction was catalyzed, and 100ml of acetic acid was added, and the reaction was refluxed and stirred at 120°C for 10h. After the reaction was completed, the product was detected by chromatography. The yield of the product is shown in Table 1

Embodiment 2

[0019] In a 250ml Teflon-lined reactor, add 0.5mmol substrate and 1.5mmol tert-butyl hydroperoxide respectively, and weigh 0.2g 2.5wt% Co / CeO 2 The reaction was catalyzed, and 100ml of pyridine was added, and the reaction was stirred at 100°C for 20h. After the reaction was completed, the product was detected by chromatography. The yield of the product is shown in Table 1

Embodiment 3

[0021] In the reactor of PTFE lining of 250ml, add 1.5mmol substrate respectively, 6mmol cumene hydroperoxide, take by weighing 0.7g 5wt% Cu / MO-V-O catalyze this reaction, and add 100ml acetonitrile, at 150 Stir the reaction at ℃ for 18h. After the reaction is over, the product is detected by chromatography. The yield of the product is shown in Table 1

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Abstract

The invention relates to a method for preparing a diphenyl ketone compound. The method adopts a metal-supported oxide as a catalyst. The method comprises the specific process: after mixing a diphenyl methane compound, an oxidant, a solvent and the catalyst, refluxing at a normal pressure or putting into a reaction kettle for sealing, and stirring. The reaction temperature is higher than 50 DEG C, the reaction time is longer than 2 h, after the reaction, the catalyst is easily separated from the reaction system and can be recycled repeatedly, and the highest yield of the diphenyl ketone compound can reach 99%. The method for preparing the diphenyl ketone compound has the advantages of simple catalyst preparation, high stability, relatively mild reaction conditions, relatively high conversion rate of the diphenyl methane compound, and relatively high yield of the diphenyl ketone compound.

Description

technical field [0001] The invention relates to a method for preparing benzophenone compounds, in particular to preparing benzophenone compounds by oxidizing diphenylmethane compounds. Background technique [0002] Benzophenone is a transparent crystal at normal temperature and pressure. It is mainly used in the synthesis of drugs, the manufacture of spices, and can also be used in film manufacturing. Benzophenone compounds are widely used in pharmaceutical synthesis, perfumery and polymer materials, and can also be used as photosensitizers for thin film coatings. They are very important fine chemicals. [0003] At present, the reported industrial synthesis routes of benzophenones mainly include carbonylation, acylation, nitric acid oxidation and so on. The carbonylation method generally reacts under high temperature and high pressure; a large amount of waste acid is generated during the acylation process, which corrodes the equipment and makes it difficult to reuse the cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B41/06C07C45/28C07C45/36C07C49/786C07C49/813C07C49/784B01J23/652B01J23/83B01J23/656B01J23/888B01J23/66B01J23/745B01J23/847
Inventor 王峰王业红徐杰张晓辰陈贵夫
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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