A kind of preparation method of radiation crosslinking modified gelatin film

A technology of cross-linking modification and gelatin film, which is applied in the fields of medicine and food, which can solve the problems of chemical substance residue, gelatin biological activity and stability decline, etc., and achieve excellent performance, reduce the difficulty of gelatin film removal, and good mechanical properties.

Inactive Publication Date: 2016-03-02
FARM PROD PROCESSING & NUCLEAR AGRI TECH INST HUBEI ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological activity and stability of gelatin decreased after chemical cross-linking modification, and the problem of residual chemical substances was more serious [Translated by Lu Xili. Mechanical and thermal properties of glutaraldehyde cross-linked gelatin films to different degrees. Western Leather. 2009, 31 (3):54-57]

Method used

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  • A kind of preparation method of radiation crosslinking modified gelatin film
  • A kind of preparation method of radiation crosslinking modified gelatin film
  • A kind of preparation method of radiation crosslinking modified gelatin film

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A preparation method for radiation cross-linked modified gelatin film, comprising the steps of:

[0027] 1) Preparation of gelatin-glycerol aqueous solution: Weigh 5 grams of gelatin and 40 grams of water, mix and swell at room temperature for 1 hour, dissolve in a water bath at 50° C., add 1 gram of glycerin, and mix well to obtain a gelatin-glycerin aqueous solution for use;

[0028] 2) Preparation of the anti-sticking layer of the tray: Weigh 10 grams of sodium stearate and 90 grams of water, mix them, dissolve them in hot water at 90°C, and adjust the pH of the sodium stearate-water mixture to 8 with 30wt% NaOH aqueous solution to obtain a paste (at this time, the paste changes from white to transparent); spread the paste evenly on the bottom of the tray, let it dry to form an anti-adhesive layer, and wait for use (a tray coated with an anti-adhesive layer);

[0029] 3) Pour the gelatin-glycerin aqueous solution into a tray coated with an anti-stick layer, and cool ...

Embodiment 2

[0046] A preparation method for radiation cross-linked modified gelatin film, comprising the steps of:

[0047] 1) Preparation of gelatin-glycerol aqueous solution: Weigh 5 grams of gelatin, 40 grams of water, swell at room temperature for 1 hour after mixing, dissolve in a water bath at 50° C., add 2 grams of glycerin, mix to obtain a gelatin-glycerin aqueous solution, and set aside;

[0048] 2) Preparation of the anti-sticking layer of the tray: Weigh 10 grams of sodium stearate and 90 grams of water, mix them, dissolve them in hot water at 90°C, and adjust the pH of the sodium stearate-water mixture to 8 with 30wt% NaOH aqueous solution to obtain a paste (at this time, the paste changes from white to transparent); spread the paste evenly on the bottom of the tray, let it dry to form an anti-adhesive layer, and wait for use (a tray coated with an anti-adhesive layer);

[0049] 3) Pour the gelatin-glycerin aqueous solution into a tray coated with an anti-stick layer, and cool...

Embodiment 3

[0056] A preparation method for radiation cross-linked modified gelatin film, comprising the steps of:

[0057] 1) Preparation of gelatin-glycerol aqueous solution: Weigh 5 grams of gelatin, 40 grams of water, swell at room temperature for 40 minutes after mixing, dissolve in a water bath at 55° C., add 2.5 grams of glycerin, and mix well to obtain a gelatin-glycerin aqueous solution for use;

[0058] 2) Preparation of the anti-sticking layer of the tray: Weigh 10 grams of sodium stearate and 90 grams of water, mix them, dissolve them in hot water at 90°C, and adjust the pH of the sodium stearate-water mixture to 9 with 20wt% NaOH aqueous solution to obtain a paste (at this time, the paste changes from white to transparent); spread the paste evenly on the bottom of the tray, let it dry to form an anti-adhesive layer, and wait for use (a tray coated with an anti-adhesive layer);

[0059] 3) Pour the gelatin-glycerin aqueous solution into a tray coated with an anti-sticking laye...

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Abstract

The invention belongs to the technical field of foods and medicines and provides a preparation method of an irradiation-crosslinked modified gelatin film. The preparation method is characterized by comprising the following steps: (1) selecting raw materials according to the condition that a mass ratio of gelatin to water to glycerol is 1:8:(0.2-1); (2) mixing to obtain a gelatin-glycerol water solution; (3) selecting the raw materials according to the condition that a mass ratio of sodium stearate to water is 1:9, and mixing to obtain a transparent pasty material; (4) uniformly coating the transparent pasty material obtained in the step (3) on the bottom inside a plastic tray, and air-drying to obtain an anti-adhesion layer for later use; (5) pouring the gelatin-glycerol water solution prepared in the step (2) into the tray coated with the anti-adhesion layer; (6) drying to obtain a solidified gelatin film; (7) irradiating the gelatin film solidified in the step (6) at room temperature by an irradiation source at an irradiation dose of 4-8 kGy; (8) drying the gelatin film irradiated in the step (7) and uncovering the film to obtain the irradiation-crosslinked modified gelatin film. The gelatin film prepared by the method has good mechanical properties and can be used as a film material for foods and medicines.

Description

technical field [0001] The invention belongs to the technical fields of food and medicine, and in particular relates to a preparation method of a radiation crosslinked modified gelatin film. Background technique [0002] Gelatin has excellent physical and chemical properties, and is widely used in the pharmaceutical industry and biomedical fields, such as hard and soft capsules, microspheres, artificial vascular sealants, wound dressings, surgical adsorption pads, drug sustained-release materials, etc. However, gelatin has problems such as brittle texture after drying, weak forming ability, water swelling, and poor resistance, which cannot meet the development needs of medicine and other fields. In order to improve the application properties of gelatin, glutaraldehyde, carbodiimide, epoxy compounds and genipal are currently used to cross-link and modify gelatin collagen, which can improve the mechanical properties of gelatin. However, the biological activity and stability o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08J5/18C08J3/24C08J3/28C08L89/00
Inventor 耿胜荣鉏晓艳廖涛李新熊光权夏和舟江洪有
Owner FARM PROD PROCESSING & NUCLEAR AGRI TECH INST HUBEI ACAD OF AGRI SCI
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