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Chinese herba preparation for treating nephrotic syndrome proteinuria and preparation method thereof

A technology for nephrotic syndrome and traditional Chinese medicine preparations, applied in the field of traditional Chinese medicine, can solve problems such as differences in incidence and severity, serious adverse reactions, etc.

Inactive Publication Date: 2014-06-25
SHANXI PROVINCE CHINESE MEDICINE RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its adverse reactions are also very serious, mainly manifested in the aspects of digestion, urology, reproduction, hematopoietic system and skin, etc. The incidence and severity will vary greatly due to different preparations

Method used

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  • Chinese herba preparation for treating nephrotic syndrome proteinuria and preparation method thereof
  • Chinese herba preparation for treating nephrotic syndrome proteinuria and preparation method thereof
  • Chinese herba preparation for treating nephrotic syndrome proteinuria and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: A kind of traditional Chinese medicine preparation for the treatment of proteinuria in nephrotic syndrome, made of the following raw materials in parts by weight: 9 grams of Astragalus membranaceus, 9 grams of Fructus Shayuanzi, 6 grams of Cornus officinalis, 15 grams of Chinese yam, 9 grams of Gorgon fruit, 6 grams of Angelica sinensis, Motherwort 9 grams. The raw materials are mixed in proportion and then decocted. When decocting for the first time, water of 5 times the amount of raw materials is added for 1.5 hours. When decocting for the second time, water of 3.5 times the amount of raw materials is added for 1.5 hours. The two decoctions are combined and concentrated, and the filtrate is concentrated to a clear ointment with a relative density of 1.15-1.30 at 50-80°C, and starch excipients of 1 times the amount of the concentrated ointment are added to make tablets.

Embodiment 2

[0016] Embodiment 2: A kind of traditional Chinese medicine preparation for the treatment of proteinuria in nephrotic syndrome, made of the following raw materials in parts by weight: 30 grams of Radix Astragali, 6 grams of Fructus Shayuanzi, 6 grams of Cornus officinalis, 12 grams of Chinese yam, 6 grams of Gorgon fruit, 15 grams of Angelica sinensis, Motherwort 15 grams. The preparation method is the same as the preparation method described in Example 1, and the dextrin excipient of 1 times the amount of the concentrated ointment is added to make a granular powder.

Embodiment 3

[0017] Embodiment 3: A kind of traditional Chinese medicine preparation for the treatment of proteinuria in nephrotic syndrome, made of the following raw materials in parts by weight: 20 grams of Radix Astragali, 15 grams of Fructus Shayuanzi, 8 grams of Cornus officinalis, 30 grams of Chinese yam, 15 grams of Gorgon fruit, 8 grams of Angelica sinensis, Motherwort 30 grams. The preparation method is the same as the preparation method described in Example 1, and the starch excipient of 1 times the amount of the concentrated ointment is added to make a pill.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, provides a Chinese herba preparation for treating nephrotic syndrome proteinuria and a preparation method thereof, and aims to effectively control proteinuria, delay the evolution of nephrotic syndrome, and effectively regulate imbalance of nephrotic syndrome T lymphocyte subpopulation. The Chinese herba preparation is prepared from astragalus membranaceus, flatstem milkvetch seed, dogwood, Chinese yam, gorgon fruit, angelica sinensis, and leonurus according to certain proportion. According to the Chinese herba preparation, astragalus membranaceus which has functions of invigorating the spleen, supplementing qi, tonifying deficiency and inducing diuresis to alleviate edema is taken as the main raw material, flatstem milkvetch seed and dogwood which have functions of tonifying the liver and kidney and securing essence and reducing urination and the Chinese yam and gorgon fruit which have functions of tonifying the kidney, arresting seminal emission, tonifying the spleen and clearing damp are taken as ministerial drugs, the angelica sinensis and leonurus which have functions of enriching and activating blood and inducing diuresis to reduce edema are taken as auxiliary drugs, and all the components are compatible, so that the Chinese herba preparation can treat both syndromes and root causes, tonify qi, the kidney and the spleen, and activate blood. The experiment research on an adriamycin nephropathy rat model proves that the Chinese herba preparation has obvious protective effect for renal pathological lesion caused by doxorubicin, can be used for treating nephrotic syndrome and is applicable to people with abnormal nephrotic proteinuria immunity.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine preparation for treating nephrotic syndrome proteinuria and a preparation method thereof. Background technique [0002] Nephrotic syndrome is a large amount of proteinuria, hypoalbuminemia, edema and hyperlipidemia caused by various reasons. It is one of the main types of kidney diseases and seriously endangers human health. According to statistics, there are more than 6 million kidney disease patients in my country, which ranks among the top in the world. Nephrotic syndrome is a large amount of proteinuria, hypoalbuminemia, edema and hyperlipidemia caused by various reasons. It is one of the main types of kidney diseases and seriously endangers human health. Its pathological feature is the pathological damage caused by the loss of a large amount of plasma protein caused by the destruction of the glomerular filtrati...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P13/12
Inventor 武玉鹏贾力莉牛艳艳白崇智仲启明宋美卿仝立国冯玛莉靳桂春
Owner SHANXI PROVINCE CHINESE MEDICINE RES INST
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