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A kind of compound gastrodia elata tablet, preparation method and application thereof

A technology of Tianma tablet and Tianma tablet, which is applied in the field of food-drug dual-purpose drug combination, can solve problems such as unsatisfactory activity, and achieve the effect of enhancing immunity

Active Publication Date: 2017-04-05
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrodia elata has a variety of active ingredients, but traditional black gastrodia elata or Gastrodia elata is administered alone, which often has the problem of unsatisfactory activity

Method used

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  • A kind of compound gastrodia elata tablet, preparation method and application thereof
  • A kind of compound gastrodia elata tablet, preparation method and application thereof
  • A kind of compound gastrodia elata tablet, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The investigation of the extraction method of the compound gastrodia elata extract of embodiment 1

[0023] 1. Preparation of compound gastrodia elata extract

[0024] According to the formula of Gastrodia elata, cistanche, wolfberry and epimedium weight ratio 24:8:8:3, weigh 9 samples of mixed medicinal powder, each sample 4.0g, add extraction solvent 40ml to extract according to the conditions in Table 1, filter, extract The temperature of the liquid is adjusted to 50°C, recovered until there is no alcohol smell, and diluted to contain 0.6kg of the original medicinal material per liter of the extract; the extract is cooled to 5±3°C, left to stand, the supernatant is taken, concentrated, and the infusion with a density of 1.4 paste; dissolve the extract with methanol, and set the volume to 20ml, shake up, carry out HPLC detection, and calculate the content of gastrodin by the peak area according to the external standard method. The results show that: the extraction ra...

Embodiment 2

[0051] The screening of embodiment 2 black gastrodia elata tablet preparation conditions

[0052] 1. Screening of the types of disintegrants

[0053] Taking the particle shape, water content of the granules, the hardness of the plain tablet, and the dissolution curve as the investigation indicators, the dosage of the disintegrant was fixed at 5%, and the disintegrants sodium carboxymethyl starch and croscarmellose sodium were investigated. The formula is shown in Table 7, and the test results are shown in Table 8.

[0054] Table 7 Screening of the types of disintegrants (50 tablets per formulation)

[0055]

[0056] Preparation method: Weigh the raw and auxiliary materials of the formula respectively, mix them evenly, add an appropriate amount of binder to make a suitable soft material, pass through a 30-mesh sieve to granulate, dry at (50±5)°C until the water content is less than 3.0%, and use a 30-mesh Sieve for granulation, add magnesium stearate, mix and compress into...

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Abstract

The invention provides a compound gastrodia elata f.glauca tablet. The active ingredients of the formula are composed of gastrodia elata f.glauca, cistanche, medlar and herba epimedii. The activity of the formula in the aspect of boosting immunity is obviously superior to that of gastrodia elata f.glauca medicated independently, and moreover, the action of the alcohol extract of the compound gastrodia elata f.glauca combination is superior to that of an aqueous extract, and is basically the same as that of compound gastrodia elata f.glauca medicated fully. In addition, it is found by virtue of a contrast experiment that, the activity of gastrodia elata f.glauca used as a principal medicine in the formula is superior to that of gastrodia elata used as a principal medicine.

Description

technical field [0001] The invention relates to a combination of food and medicine, in particular to a compound gastrodia elata tablet with good activity in enhancing immunity, a preparation method and application thereof. [0002] technical background [0003] In China, some scholars conducted statistics on the health food announced by the State Food and Drug Administration from 2006 to 2010, and found that there were 829 applications for the initial registration of health food approved by the State Food and Drug Administration in 2006. Food (pure Chinese medicine, containing Chinese medicine or containing Chinese medicine extract) 458, accounting for about 55.2%; 407 applications for initial registration of health food approved in 2007, 195 applications for health food of traditional Chinese medicine, accounting for about 48.2%; approved in 2008 There were 642 applications for initial registration of health food and 303 applications for traditional Chinese medicine health f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8988A61K9/20A61P37/04
Inventor 罗杨詹永杨大坚吴振师萱张成生
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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