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Europium ion-doped high-molecular fluorescent encoding microsphere and preparation method thereof

A fluorescent coding and polymer technology, applied in the field of luminescent materials, can solve the problems of large workload, cumbersome experimental conditions, limited application scope, etc., and achieve the effect of convenient operation and simple process

Inactive Publication Date: 2014-07-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The experimental conditions of this method are cumbersome, the europium ion chelate must be prepared first, and the workload is large
[0004] Before the present invention was made, Suzhou Nanomicrobe Technology Co., Ltd. produced and sold a surface sulfonated polystyrene-divinylbenzene cross-linked (PSDVB) microsphere with a maximum excitation wavelength of about 330 (300-350 nm), the maximum emission wavelength is around 395 nm, the microsphere has only one emission wavelength after being excited, and cannot be used for fluorescence encoding, so it can only be used as a simple matrix ball, and its application range is limited

Method used

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  • Europium ion-doped high-molecular fluorescent encoding microsphere and preparation method thereof
  • Europium ion-doped high-molecular fluorescent encoding microsphere and preparation method thereof
  • Europium ion-doped high-molecular fluorescent encoding microsphere and preparation method thereof

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Embodiment 1

[0020] This embodiment provides polymer fluorescently encoded microspheres doped with europium ions, and the preparation steps are as follows:

[0021] 1. Preparation of Eu 3+ the solution

[0022] 0.0352g of Eu 2 o 3 Dissolve in 1mL CH 3 In COOH, make a 100mL solution with deionized water, heat and shake to dissolve, and obtain colorless and transparent Eu 3+ solution.

[0023] 2. Preparation of polymer fluorescently encoded microspheres doped with europium ions

[0024] Add isopropanol: deionized water = 1:1 solvent 40mL, Eu 3+ Solution (M Eu =0~20 μmol), PSDVB microspheres 75㎎ (provided by Suzhou Nabibiology Technology Co., Ltd.), polyvinylpyrrolidone (PVP) 60㎎, put into high temperature shaking incubator (setting 80℃, 220 rpm), constant temperature 80 °C for 3 hours. After the reaction, the mixture was centrifuged (2000 rpm), and then the microspheres were washed three times with deionized water (shock first: 1000 rpm, then centrifuge: 2000 rpm, remove the superna...

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Abstract

The invention relates to a europium ion-doped high-molecular fluorescent encoding microsphere and a preparation method thereof. The fluorescent encoding microsphere has an average particle size of 5 to 10 mu m, maximum excitation wavelength of about 300 to 350 nm and maximum emission wavelength nearby 395 to 611 nm, respectively. The preparation method comprises the following steps: dispersing surface sulfonated polystyrene-divinyl benzene cross-linking (PDSVB) microspheres in a mixed solvent and adding a Eu<3+> solution, wherein a mass ratio of the microspheres to Eu<3+> is 24:1 to 480: 1; and carrying out vibration treatment at a temperature of 70 to 90 DEG C for 0.5 to 5 h and then carrying out centrifugal washing and freeze drying so as to obtain the europium ion-doped high-molecular fluorescent encoding microsphere. According to the invention, through changing addition amounts of europium ions, a series of fluorescent encoding microspheres with different europium ion-PDSVB microsphere fluorescence-emission intensity ratios are prepared and can be used in fields like biological detection and medical diagnosis.

Description

technical field [0001] The invention relates to a polymer fluorescent coded microsphere and its preparation method, in particular to doping with different amounts of europium ions to obtain the fluorescence emission intensity of a series of different europium ions and polystyrene-divinylbenzene cross-linked (PSDVB) microspheres The invention relates to a specific fluorescent coded microsphere, which belongs to the technical field of luminescent materials. Background technique [0002] Rare earth elements have unique luminescent properties and have been developed as a variety of important luminescent materials, and europium is a typical representative. Europium ions can emit a rich fluorescence spectrum after being excited, and can emit electromagnetic radiation of various wavelengths from ultraviolet to infrared. Typical red fluorescence around 611nm. [0003] Some functionalized substrates can be successfully obtained by doping europium ions into some substrates. literat...

Claims

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Application Information

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IPC IPC(8): C09K11/06
Inventor 范丽娟邵亚张伟
Owner SUZHOU UNIV