Metal nanoparticle-enhanced squashed fiber-optic atr glucose sensor

Abstract

The invention discloses a flattened optical fiber ATR (attenuated total reflectance) glucose sensor reinforced on the basis of metal nanoparticles. The flattened ATR glucose sensor comprises an optical fiber. The optical fiber comprises an optical fiber core and optical fiber cladding, the optical fiber cladding wraps the outer periphery of the optical fiber core, a flattened area is formed in the middle of the optical fiber, the metal nanoparticles grow on the surface of the flattened area of the optical fiber, and optical fiber connectors which are used for being connected with external components are respectively connected to two ends of the optical fiber. The optical fiber is a multi-mode optical fiber. The optical fiber core and the optical fiber cladding are made of silver halide materials, and light with the wavelength ranging from 4 micrometers to 18 micrometers can be transmitted through the optical fiber core and the optical fiber cladding. The length of the flattened area of the optical fiber ranges from 5 centimeters to 10 centimeters, and the thickness of the flattened area of the optical fiber ranges from 50 micrometers to 450 micrometers. The metal nanoparticles are made of precious metal or transition metal. The flattened optical fiber ATR glucose sensor has the advantages that the measurement sensitivity and the resolution can be improved, the flattened optical fiber ATR glucose sensor is applicable to being subcutaneously implanted into a human body, accordingly, the blood glucose concentration of the human body can be continuously monitored in an online manner, and the flattened optical ATR glucose sensor has an excellent clinical application prospect.

Description

technical field [0001] The present invention relates to a glucose sensor. In particular, it relates to a flattened optical fiber ATR glucose sensor based on metal nanoparticle enhancement. Background technique [0002] The incidence of diabetes is increasing day by day, and it is becoming younger and expanding. Together with tumors and cardiovascular and cerebrovascular diseases, it is listed as the three most difficult diseases in the world. A variety of complications caused by diabetes seriously threaten human health. However, there is no medical method to completely cure diabetes clinically. The traditional method of using biochemical analysis to detect diabetes is traumatic, the measurement speed is slow, improper handling of reagents and related consumables may cause pollution, and continuous measurement cannot be achieved. Minimally invasive blood glucose concentration detection technology is a continuous blood glucose detection technology for measuring glucose conce...

AI Technical Summary

Problems solved by technology

The sensitivity of the straight type is not high enough, and although the tapered and curved types have a certain degree of sensitivity enhancement, the manufacturing process is not easy to control, and it is more difficult in practical applications. Continuous real-time monitoring of blood glucose concentration

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