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Suspension containing nano emamectin benzoate particles and preparation method thereof

A technology of emamectin benzoate and suspension, which is applied in botany equipment and methods, chemicals for biological control, animal repellants, etc., and can solve problems such as unstable light

Inactive Publication Date: 2014-07-23
BEIHAI GOFAR MARINE BIOLOGICAL IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under normal circumstances, emamectin emamectin salt is relatively stable and heat-resistant, but the light is unstable

Method used

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  • Suspension containing nano emamectin benzoate particles and preparation method thereof
  • Suspension containing nano emamectin benzoate particles and preparation method thereof
  • Suspension containing nano emamectin benzoate particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Dissolve 0.01g emamectin benzoate in 100ml of isopropanol to obtain a 0.1mg / ml emamectin benzoate solution, and cool to 0°C for use. Dissolve 0.002g of methylcellulose in 1000ml of water to obtain a poor solvent, and cool to 0°C. Under stirring at 7000 rpm, the emamectin benzoate solution was quickly added to the poor solvent, and stirring was continued for 10 min to obtain an emamectin benzoate salt suspension. Take a sample with a disposable pipette, drop it on the copper net, and scan it with an electronic scanning electron microscope to obtain figure 1 Scanned photo with electron microscope shown. In addition, take 10ml of emamectin benzoate suspension and detect with a laser particle size analyzer to obtain figure 2 The particle size distribution diagram shown. Take 100ml of emamectin benzoate suspension and conduct stability experiment under normal temperature and pressure. The results showed that the emamectin benzoate suspension was stable.

Embodiment 2

[0032] Dissolve 0.1g of emamectin benzoate in 100ml of toluene to obtain a 1mg / ml emamectin benzoate solution, which is cooled to 0°C for use. Dissolve 0.002g Tween in 500ml n-hexane to obtain a poor solvent, and cool to 0°C. Under stirring at 5000 rpm, the emamectin benzoate solution was quickly added to the poor solvent, and stirring was continued for 15 minutes to obtain an emamectin benzoate salt suspension. Take a sample with a disposable pipette, drop it on the copper net, and scan it with an electronic scanning electron microscope to obtain image 3 Scanned photo with electron microscope shown. In addition, take 10ml of emamectin benzoate suspension and detect with a laser particle size analyzer to obtain Figure 4 The particle size distribution diagram shown. Take 100ml of emamectin benzoate suspension and conduct stability experiment under normal temperature and pressure. The results showed that the emamectin benzoate suspension was stable.

Embodiment 3

[0034] Dissolve 0.2g of emamectin benzoate in 100ml of acetone to obtain a 2mg / ml emamectin benzoate solution, which is cooled to 0°C for use. Dissolve 0.02g poloxamer in 1000ml water to obtain a poor solvent, and cool to 0°C. Under stirring at 1000 rpm, the emamectin benzoate solution was quickly added to the poor solvent, and stirring was continued for 20 minutes to obtain an emamectin benzoate suspension. Take a sample with a disposable pipette, drop it on the copper net, and scan it with an electronic scanning electron microscope to obtain Figure 5 Scanned photo with electron microscope shown. In addition, take 10ml of emamectin benzoate suspension and detect with a laser particle size analyzer to obtain Image 6 The particle size distribution diagram shown. Take 100ml of emamectin benzoate suspension and conduct stability experiment under normal temperature and pressure. The results showed that the emamectin benzoate suspension was stable.

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Abstract

The invention discloses a suspension containing nano emamectin benzoate particles and a preparation method thereof, and belongs to the field of pesticide preparation. The preparation method comprises the following steps: dissolving emamectin benzoate into a solvent with a good solubility so as to form a solution with a certain concentration, and then quickly adding the solution into a poor solvent containing a surfactant under stirring, because the dissolving capacity of the original solvent is reduced, the emamectin benzoate is precipitated from the mixed solution of the two solvents. The suspension prepared by the method has a good stability. The emamectin benzoate particle is in a normal ball-liked shape, the particle size distribution is narrow, and the particle size is in a nano level. The invention lays the foundation for industrial production of nano emamectin benzoate and development and utilization of novel dosage forms of nano emamectin benzoate.

Description

Technical field [0001] The invention relates to a method for preparing pesticide suspensions, in particular to a method for preparing poorly water-soluble pesticides pesticide nanoparticles by adopting an anti-solvent crystallization method. Background technique [0002] Emamectin Benzoate (Emamectin Benzoate), also known as emamectin benzoate, hereinafter referred to as emamectin salt), the chemical name is 4"-methylamino-4"-deoxyabamectin B1 benzyl The structural formula is as follows: [0003] [0004] Emamectin benzoate is a new type of high-efficiency semi-synthetic antibiotic insecticide and acaricide developed by Monsanto in the United States based on the fermented product abamectin B1. Its mechanism of action is to interfere with the neurophysiological activities of insects, stimulate the release of γ-aminobutyric acid, and inhibit the conduction of insect nerve impulses. Emamectin benzoate has the characteristics of ultra-efficient, low-toxicity, low-residue, pollution-f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N43/90A01P7/00
Inventor 陈书勤黄巧萍李有志孟宪福黄燕群何忠平覃朝望彭家安
Owner BEIHAI GOFAR MARINE BIOLOGICAL IND CO LTD
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