Method for dissolving lentinan solid powder

Abstract

The invention provides a method for dissolving lentinan solid powder. The method is characterized by comprising the following concrete steps: adding the lentinan solid powder to water; shearing by using a shearing machine at the rotating speed of 500-30000rpm for 0-30 minutes, so as to obtain evenly dispersed liquid; pouring the obtained evenly dispersed liquid into the feeding hole of a homogenizer; homogenizing for 0-3 times by adopting secondary pressure at 30-300bar, and then adjusting the pressure to 300-2000bar by adopting a first-stage homogenizing valve or first-stage and second-stage homogenizing valves, and homogenizing 2-7 times, so as to obtain a lentinan solution of which the concentration is 0.1-3.0mg / ml. By adopting the method, dissolution of the lentinan under a non-alkali condition is achieved, stable lentinan is ensured, the toxic and side effects are reduced, and the use safety of the medicine is improved; meanwhile, the method is a simple and feasible drug dissolution method.

Description

technical field [0001] The invention relates to a method for dissolving lentinan solid powder, which belongs to the category of the preparation process of biological reaction regulators. Background technique [0002] Lentinan is a biologically active glucan extracted from fruit bodies of Lentinus edodes, and contains various medicinal components. Lentinan was first extracted and purified by Japanese scholar Chihara Goro in 1968, and was officially approved for marketing as an intravenous injection in 1985. It is a biological response immunomodulator with anti-virus, anti-tumor, stimulating interferon formation and macrophages. According to the clinical application in recent years, it has strong anti-tumor activity against gastric cancer and liver cancer, and can also prevent and treat Headache, vomiting and other side effects caused by radiation therapy. [0003] Since lentinan is almost insoluble in water, it can be dissolved in 0.5mol / L sodium hydroxide solution. Theref...

AI Technical Summary

Problems solved by technology

The disadvantages are (1) due to the instability of lentinan in alkaline solution, degradation may occur, thereby reducing the curative effect of lentinan; (2) the acid-base neutralization in the preparation process will produce a certain amount of salt. When applied, it will cause adverse reactions to some patients, such as patients with cardiovascular disease or renal insufficiency; (3) using organic solvents to solubilize, clinical use will inevitably produce toxic and side effects on patients

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