Method for dissolving lentinan solid powder

A technology of lentinan and solid powder, which is applied in the field of preparation of biological reaction regulators, can solve the problems of unavoidable patient toxicity and side effects, reduce the curative effect of lentinan, and achieve the effects of avoiding adverse reactions, improving safety, and reducing toxic and side effects

Active Publication Date: 2014-07-23
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages are (1) due to the instability of lentinan in alkaline solution, degradation may occur, thereby reducing the curative effect of lentinan; (2) the acid-base neutralization in the preparation process will produce a certain amount of salt. When applied, it will cause adverse reactions to some patients, such as patients with cardiovascular disease or renal insufficiency; (3) using organic solvents to solubilize, clinical use will inevitably produce toxic and side effects on patients

Method used

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  • Method for dissolving lentinan solid powder
  • Method for dissolving lentinan solid powder
  • Method for dissolving lentinan solid powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Add 0.1g of lentinan solid powder into the prepared 1000ml of water, and shear with a shearing machine at a speed of 500rpm and a shearing time of 0min to obtain a uniformly dispersed liquid. Pour the uniformly dispersed liquid after high-speed shearing into the feed port of the homogenizer. Firstly, use the second-stage homogenizing valve to adjust the pressure to 30 bar and homogenize for 0 times. Then use the first-stage homogenizing valve to adjust the pressure to 300bar, homogenized twice to obtain a colorless and clear lentinan solution with a total concentration of 0.1mg / ml.

Embodiment 2

[0019] Add 0.1g of lentinan solid powder into the prepared 1000ml of water, and shear with a shearing machine at a speed of 15,000rpm and a shearing time of 15min to obtain a uniformly dispersed liquid. Pour the uniformly dispersed liquid after high-speed shearing into the feed port of the homogenizer. Firstly, use the second-stage homogenizing valve to adjust the pressure to 150 bar, homogenize twice, and then use the first-stage homogenizing valve to adjust the pressure to 1350bar, homogenized 5 times to obtain a colorless and clear lentinan solution with a total concentration of 0.1mg / ml.

Embodiment 3

[0021] Add 0.1g of lentinan solid powder into 1000ml of water that has been prepared, and shear with a shearing machine at a speed of 30,000rpm and a shearing time of 30min to obtain a uniformly dispersed liquid. Pour the uniformly dispersed liquid after high-speed shearing into the feed port of the homogenizer, first use the second-stage homogenizing valve, adjust the pressure to 300bar, homogenize for 3 times, and then use the first- and second-stage homogenizing valves to adjust the pressure 2000bar, homogenized 7 times to obtain a colorless and clear lentinan solution with a total concentration of 0.1mg / ml.

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Abstract

The invention provides a method for dissolving lentinan solid powder. The method is characterized by comprising the following concrete steps: adding the lentinan solid powder to water; shearing by using a shearing machine at the rotating speed of 500-30000rpm for 0-30 minutes, so as to obtain evenly dispersed liquid; pouring the obtained evenly dispersed liquid into the feeding hole of a homogenizer; homogenizing for 0-3 times by adopting secondary pressure at 30-300bar, and then adjusting the pressure to 300-2000bar by adopting a first-stage homogenizing valve or first-stage and second-stage homogenizing valves, and homogenizing 2-7 times, so as to obtain a lentinan solution of which the concentration is 0.1-3.0mg / ml. By adopting the method, dissolution of the lentinan under a non-alkali condition is achieved, stable lentinan is ensured, the toxic and side effects are reduced, and the use safety of the medicine is improved; meanwhile, the method is a simple and feasible drug dissolution method.

Description

technical field [0001] The invention relates to a method for dissolving lentinan solid powder, which belongs to the category of the preparation process of biological reaction regulators. Background technique [0002] Lentinan is a biologically active glucan extracted from fruit bodies of Lentinus edodes, and contains various medicinal components. Lentinan was first extracted and purified by Japanese scholar Chihara Goro in 1968, and was officially approved for marketing as an intravenous injection in 1985. It is a biological response immunomodulator with anti-virus, anti-tumor, stimulating interferon formation and macrophages. According to the clinical application in recent years, it has strong anti-tumor activity against gastric cancer and liver cancer, and can also prevent and treat Headache, vomiting and other side effects caused by radiation therapy. [0003] Since lentinan is almost insoluble in water, it can be dissolved in 0.5mol / L sodium hydroxide solution. Theref...

Claims

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Application Information

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IPC IPC(8): C08J3/05C08L5/02
Inventor 朱益锋金幸陈林祥赵蕾
Owner 上海慈瑞医药科技股份有限公司
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