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Anti-adhesion dry powder inhaler used after orthopedic surgeries and preparing method thereof

An anti-adhesion powder spray, orthopedic postoperative technology, applied in the field of medicine, can solve problems such as limited joint movement, and achieve good adhesion, low cost, and convenient use

Inactive Publication Date: 2014-08-06
QINGDAO CITY CHENGYANG DISTRICT PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process occurs in the joint capsule, sarcolemma, muscle junction tissue, ligaments, etc., resulting in limited joint motion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] An anti-adhesion powder spray for orthopedic surgery, which is composed of sodium hyaluronate, carboxymethyl chitin and sodium nitroprusside, and the mass ratio of the three is 1:1:0.1.

Embodiment 2

[0017] An anti-adhesion powder spray for orthopedic surgery, which is composed of sodium hyaluronate, hydroxypropyl chitin and nifedipine, and the mass ratio of the three is 1:0.5:0.05.

Embodiment 3

[0019] An anti-adhesion powder mist for orthopedic surgery, which is composed of sodium hyaluronate, succinyl chitin and prazosin, and the mass ratio of the three is 1:0.3:0.02.

[0020] Examples 1-3 were prepared according to the following preparation method. Sodium hyaluronate, chitin derivatives and spasm inhibitors were weighed and mixed according to the above formula, then ground into fine powder, and the fine powder was passed through a 200-mesh sieve. The fine powder is packaged in an aluminum foil bag, and after ethylene oxide or microwave sterilization, the anti-adhesion powder for orthopedic surgery is obtained.

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PUM

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Abstract

The invention belongs to the field of medicines and particularly relates to an anti-adhesion dry powder inhaler used after orthopedic surgeries and a preparing method thereof. The anti-adhesion dry powder inhaler consists of sodium hyaluronate, a chitin derivative and an anti-inflammation analgetic, wherein the mass ratio of the sodium hyaluronate to the chitin derivative to a spasm inhibitor is 1: (0.3 - 1): (0.01 - 0.1). During preparation, the sodium hyaluronate, the chitin derivative and the spasm inhibitor are weighed and mixed according to the formula and then ground into fine powder, the fine powder is sieved by a 200-mesh screen, the sieved fine powder is packaged by an aluminum foil bag, and the anti-adhesion dry powder inhaler for the orthopedic surgeries is obtained after being sterilized by ethylene oxide or microwaves. The anti-adhesion dry powder inhaler used after the orthopedic surgeries and the preparing method thereof have the advantages that all the ingredients of the medicine are matched with one another and prepared into the powder inhaler; the powder inhaler has remarkable effects of preventing adhesion among joins and tissues after the surgeries, repairing wounds, promoting healing, alleviating pain and diminishing inflammations; the powder inhaler has stable quality, is low in cost and convenient to use, has great adhesion with the tissue and meets clinic use requirements.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an anti-adhesion powder mist for orthopedic surgery and a preparation method thereof. Background technique [0002] Joint adhesion refers to the movement disorder caused by changes in the skin, muscles, tendons, blood vessels and nerves around the joint. There are loose components and dense components in the tissues of the human body. The former constitute joint capsules, muscle-combining tissue layers, subcutaneous tissue, etc., which are often active parts. Histologically, the collagen fibers and fine mesh fibers do not have a mesh shape and do not have a certain structure. . In contrast, densely bonded tissues, such as fascia and aponeurosis, form a dense network. The scar that forms after an injury is this tissue. During the treatment of orthopedic joint trauma, if the movement of the site is maintained, the loose joint tissue can be maintained; on the contrary, if the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/728A61K9/12A61P41/00A61K31/722A61K31/517A61K31/4422A61K33/26
Inventor 纪翔苏世先胡全君
Owner QINGDAO CITY CHENGYANG DISTRICT PEOPLES HOSPITAL