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Natto kinase oral emulsion and preparation method thereof

The technology of soybean kinase oral emulsion and nattokinase, which is applied in the field of pharmaceutical preparations, can solve the problems of low cost of NK oral preparation, influence on the molding of pellet preparations, and inconvenience in production, and achieve improved thermal stability and placement stability, and easy large-scale production. The effect of large-scale production and low production cost

Active Publication Date: 2014-08-13
SUNGEN BIOSCIENCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this method also has some disadvantages: (1) due to the low coating temperature (30°C), it is easy to cause the adhesion of the pellets, which affects the molding of the pellet preparation; (2) the pellets also need a low temperature ( 30°C) for the film healing process in the oven, due to the low temperature, the film healing time is as long as 8 hours, which also brings inconvenience to production
[0021] In summary, the preparation workers have done a lot of work in the development of NK oral preparations, and have given many plans, but so far have not found one that can simultaneously take into account the good oral absorption of NK, strong activity retention, simple process and low preparation cost. Program

Method used

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  • Natto kinase oral emulsion and preparation method thereof
  • Natto kinase oral emulsion and preparation method thereof
  • Natto kinase oral emulsion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0061] A kind of nattokinase oral emulsion, described emulsion comprises oil phase and water phase, and described water phase is the nattokinase aqueous solution that concentration is 10000IU / mL, and described oil phase contains following total weight based on described oil phase Each component of percentage by weight: SPC10% (w / w), beeswax 5% (w / w), RH402.5% (w / w), DCA0.5% (w / w), balance is MCT. Meanwhile, the ratio between the weight in grams of the oil phase and the volume in milliliters of the aqueous phase is 5:1.

[0062] Preparation:

[0063] The nattokinase lyophilized powder that takes formula quantity is dissolved in water, obtains water phase;

[0064] Weigh the formula amount of SPC, beeswax, RH40, DCA and MCT, put a total of 10g into a 25mL beaker, stir and mix at a constant temperature in a 65°C water bath until uniformly dispersed, and obtain an oil phase, cool at room temperature for use;

[0065] The temperature of the oil phase was controlled at 37°C, the ...

Embodiment 2

[0068] A kind of nattokinase oral emulsion, described emulsion comprises oil phase and water phase, and described water phase is the nattokinase aqueous solution that concentration is 100IU / mL, and described oil phase contains following total weight based on described oil phase Each component of weight percent: SPC10% (w / w), EPC1.6% (w / w), beeswax 5% (w / w), RH402.5% (w / w), DCA0.5% (w / w), the balance is MCT80.4%. Meanwhile, the ratio between the weight in grams of the oil phase and the volume in milliliters of the aqueous phase is 5:1.

[0069] Preparation:

[0070] The nattokinase lyophilized powder that takes formula quantity is dissolved in water, obtains water phase;

[0071] Weigh the formula amount of SPC, EPC, beeswax, RH40, DCA and MCT, put a total of 10g into a 25mL beaker, stir and mix at a constant temperature in a water bath at 65°C until uniformly dispersed, and obtain an oil phase, cool at room temperature for use;

[0072] The temperature of the oil phase wa...

Embodiment 3

[0075] A kind of nattokinase oral emulsion, described emulsion comprises oil phase and water phase, and described water phase is the nattokinase aqueous solution that concentration is 1000IU / mL, and described oil phase contains following total weight calculation based on described oil phase Each component of weight percentage: EPC11.6% (w / w), beeswax 5% (w / w), RH402.5% (w / w) DCA0.5% (w / w), balance is MCT. Meanwhile, the ratio between the weight in grams of the oil phase and the volume in milliliters of the aqueous phase is 5:1.

[0076] Preparation:

[0077] The nattokinase lyophilized powder that takes formula quantity is dissolved in water, obtains water phase;

[0078] Weigh the formula amount of EPC, beeswax, RH40, DCA and MCT, put a total of 10g into a 25mL beaker, stir and mix at a constant temperature in a 65°C water bath until uniformly dispersed to obtain an oil phase, and cool at room temperature for later use;

[0079] The temperature of the oil phase was control...

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Abstract

A natto kinase oral emulsion is composed of an oil phase and an aqueous phase; wherein the aqueous phase is a natto kinase water solution with a concentration of 100 to 10000 IU / mL; and the oil phase is composed of the following components in percentage by the total weight of the oil phase: 8 to 12% of phosphatide, 4 to 6% of bee wax, 0.4 to 1% of deoxycholic acid, 1.25 to 5% of auxiliary emulsifier, and the balance being oil. The invention also provides a preparation method of the oral emulsion. The oral emulsion can prominently improve the thermal stability and preservation stability of natto kinase, and improve the drug effect of orally-taken natto kinase at the same time. Furthermore, the preparation method has the advantages of simple operation, low production cost, and easiness for large-scale production.

Description

technical field [0001] The application relates to the field of pharmaceutical preparations, more specifically, to a nattokinase oral emulsion, a preparation method thereof, and a capsule filled with the emulsion. Background technique [0002] 1. Brief Introduction of Nattokinase [0003] Natto (natto) originated in ancient China and is a food made from soybeans fermented by Bacillus natto. During the Tang Dynasty, natto was introduced to Japan by Master Jianzhen. It first developed in temples, and gradually became popular among Japanese people, occupying an important position on the Japanese table. In the 1980s, Hiroyuki Sumi (必见洋行), who was engaged in thrombus research in the United States, used artificial thrombus plates to screen a large number of various natural products in order to find new antithrombotic substances. In an accidental attempt, he discovered that natto has a strong ability to dissolve artificial thrombus. After in-depth research, he finally isolated a s...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/107A61K9/48A61P7/02
Inventor 陈杰鹏陈煜藩陈鸿锐邱雪莲段丽丽胡留松纪烨瑜蔡桂珠许志锴叶红林洪琳黄晓莹
Owner SUNGEN BIOSCIENCE CO LTD
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