Polyhydroxyl polymer embolized microsphere and preparation process thereof

Abstract

The invention relates to a polyhydroxyl polymer embolized microsphere, which is formed by cross-linking polymerization of biocompatible functional macromolecules. The embolized microsphere is characterized in that the functional macromolecule comprises a polymer, wherein at least two acetal structures containing acrylic acid or derivative radicals thereof connected on the main chain or at least two crosslinkable micro-molecules which are connected in a covalent bond mode and have acrylic acid or derivative structures thereof; the acetal structures or crosslinkable micro-molecules can form a hydrogel unsaturated functional group through free radical polymerization crosslinking; a functional group by using organic carboxylate as a negative charge carrier is contained inside the microsphere. The invention also provides a preparation process of the polyhydroxyl polymer embolized microsphere. The embolized microsphere has excellent biocompatibility and stability, large elastic stretching rate and recoverability, is uniform and controllable in granularity, excellent in dispersion, simple in use and operation and strong in targeting property, has excellent adsorption capability to bioactive substances, and can be used for various minimally invasive treatment.

Description

technical field [0001] The invention relates to an embolization microsphere used for intervention therapy to treat tumor diseases and a preparation process thereof, belonging to the technical field of medical materials. Background technique [0002] Minimally invasive interventional therapy is becoming more and more widely used in the field of medical technology, especially in the treatment of cancer tumors rich in blood vessels such as liver cancer, kidney cancer, and uterine fibroids, and has become an important tool for the treatment of tumors that cannot be surgically removed. preferred alternative to . The principle is to use high-definition medical imaging equipment to guide the catheter through the artery to the tumor site in the human body, and then perfuse the catheter with anti-tumor drugs and embolic agents to block the blood supply of the tumor tissue, so that the tumor shrinks in a short time. Therapeutic purposes of necrosis. The key to minimally invasive int...

AI Technical Summary

Problems solved by technology

The key to minimally invasive interventional therapy is to choose an appropriate embolic agent for blocking blood supply to tumor tissue. The physical characteristics of embolic agents are crucial to the final efficacy of interventional therapy. The size is too large, or the size distribution is too wide, and the shape is irregular. The embolic agent products will cause the following problems in interventional surgery: (1) blockage of the catheter; (2) misembolization, that is, the embolization point is too far away from the tumor tissue, causing damage to normal tissue; (3) drift, that is, the embolic agent in the After the operation, leave the predetermined embolization position and enter other blood vessels; (4) The target blood vessel cannot be completely embolized

Although the obtained embolic agent can be loaded with drugs, the steps in the actual operation are cumbersome. It needs to dry the surface of the microspheres in advance, and then soak the microspheres in a solution of chemotherapeutic drugs at a temperature of 4°C for 2 hours, and then Wash with deionized water to remove unexchanged drugs on the surface before use

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