Pharmaceutical composition for treating chronic periapical periodontitis and use thereof

A technology for apical periodontitis and a composition is applied in the fields of pharmaceutical compositions for treating chronic apical periodontitis and pharmaceutical compositions for treating refractory chronic periapical periodontitis, and can solve the problems of poor root canal treatment effect and clinical problems. Symptoms and signs do not disappear, sensitivity decreases, etc., to achieve strong inhibitory and killing effects, good antibacterial effects, and safe use.

Inactive Publication Date: 2014-08-27
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Refractory chronic apical periodontitis manifests as decreased sensitivity of infected foci to root canal irrigation drugs, disinfectants and antibiotics, clinical symptoms and signs do not disappear, and conventional root canal treatment is not effective

Method used

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  • Pharmaceutical composition for treating chronic periapical periodontitis and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The preparation of embodiment 1 duckweed aqueous extract

[0012] Take duckweed 1kg, use 10 times of amount (V / W) concentration as 95% ethanol aqueous solution to carry out heating and reflux extraction, the number of times of its extraction is 3 times, and the time of each extraction is 2 hours, discards extracting solution, remaining Add 8 times the amount (V / W) of pure water to the filter residue, heat and reflux to extract twice, combine the filtrates and concentrate to a thick paste with a relative density of 1.25 to 1.35 at 75°C, freeze-dry, pulverize, and pass through a 100-mesh sieve to obtain duckweed water extract.

Embodiment 2

[0013] The preparation of embodiment 2 duckweed water extract

[0014] Take by weighing duckweed 5kg, be that 95% ethanol aqueous solution carries out heat reflux extraction with 8 times of amount (V / W) concentration, the number of times of its extraction is 3 times, and the time of each extraction is 2 hours, discards extracting solution, remaining Add 8 times the amount (V / W) of pure water to the filter residue, heat and reflux to extract twice, combine the filtrates and concentrate to a thick paste with a relative density of 1.25 to 1.35 at 70°C, freeze-dry, pulverize, and pass through a 100-mesh sieve to obtain duckweed water extract.

Embodiment 3

[0015] Example 3 Experimental research on the dominant flora of duckweed water extract against refractory chronic apical periodontitis

[0016] 24 patients with refractory chronic apical periodontitis had 24 teeth, including 14 males and 10 females, aged 36-57 years. The diagnostic criteria for refractory chronic apical periodontitis: teeth that have undergone routine root canal dressing changes for more than 3 times but have not yet met the root canal filling requirements, have protracted fistula or long-term percussion pain. Inclusion criteria: clinically diagnosed teeth with refractory chronic apical periodontitis; X-ray films showed that the roots of the affected teeth were fully developed, and there were low-density images around the apex. Exclusion criteria: the affected teeth had periodontal and pulpal lesions; the affected teeth had root fractures, longitudinal fissures, or device separation; they had taken antibiotics within the past month; they had systemic chronic w...

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Abstract

The invention relates to a pharmaceutical composition for treating chronic periapical periodontitis and a use thereof. An active component of the pharmaceutical composition is duckweed aqueous extract. A preparation method of the duckweed aqueous extract comprises the following steps of carrying out heating backflow extraction on duckweed by ethanol, carrying out filtration, removing the filtrate, collecting the herb residues, adding water into the herb residues, carrying out heating backflow extraction, carrying out filtration, concentrating the filtrate, carrying out drying and carrying out crushing. The pharmaceutical composition has strong inhibition and killing effects on dominant bacterial community of intractable chronic periapical periodontitis and especially on gram-negative bacteria, and can be used for treating chronic periapical periodontitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, specifically relates to a pharmaceutical composition for treating chronic periapical periodontitis, and in particular provides a pharmaceutical composition for treating refractory chronic periapical periodontitis and its application. Background technique [0002] Chronic apical periodontitis is a common and frequently-occurring disease in clinical oral cavity, and refractory and chronic apical periodontitis (refractory and chronic apical periodontitis) troubles most clinicians because of its long-lasting lesions and poor curative effect. Refractory chronic apical periodontitis manifests as decreased sensitivity of the infected focus to root canal irrigation drugs, disinfectant drugs, and antibiotics, clinical symptoms and signs do not disappear, and the effect of conventional root canal treatment is not good. Clinically, these periapical periodontitis that cannot be cured for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P1/02
Inventor 杨芳阎潇陈正岗袁晓于江波郭大伟
Owner QINGDAO MUNICIPAL HOSPITAL
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