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Anti-tumor pharmaceutical use of pentacyclic triterpene saponin compounds of szechuan melandium root

A compound and drug technology, applied in the field of medicine, can solve the problems of few pharmacological research reports and achieve the effect of less side effects

Active Publication Date: 2014-09-03
王学勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the researches on wattle grass mainly focus on the research on chemical constituents, and there are few reports on pharmacological research.

Method used

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  • Anti-tumor pharmaceutical use of pentacyclic triterpene saponin compounds of szechuan melandium root
  • Anti-tumor pharmaceutical use of pentacyclic triterpene saponin compounds of szechuan melandium root
  • Anti-tumor pharmaceutical use of pentacyclic triterpene saponin compounds of szechuan melandium root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0257] The preparation of embodiment 1 total saponins

[0258] Get tile grass 21kg, after crushing, extract three times respectively with 170L of 95% ethanol and 70% ethanol, concentrate to obtain extractum 7kg, after the extractum is diluted with water, pass through D101 macroporous resin, water, 10% ethanol, 70% extract respectively Gradient elution with ethanol and 90% ethanol, and 90% of the eluted part is the total saponin of the plant. The content of the total saponin is determined by spectrophotometry, and the content of the total saponin reaches 61.2%.

Embodiment 2

[0259] The preparation of embodiment 2 tile grass pentacyclic triterpenoids

[0260] Get tile grass 21kg, after crushing, extract three times respectively with 170L of 95% ethanol and 70% ethanol, concentrate to obtain extractum 7kg, after the extractum is diluted with a large amount of water, pass through D101 macroporous resin, water, 10% ethanol, 70% ethanol, 90% ethanol gradient elution, wherein the 90% elution part obtained a total weight of 5 kg of extract. 90% part was separated by Sephadex LH-20 column, then passed through MCI column, eluted with water, 30%, 50%, 60%, 70%, 90%, 95%, 100% methanol in sequence, and then repeatedly passed through Sephadex LH-20 , obtain macromolecular compound compound 1 (sinocrassuloside VI), compound 2 (sinocrassuloside VII), compound 3 (sinocrassuloside VIII), compound 4 (sinocrassuloside IX), compound 7 (sinocrassuloside XII), compound 8 (sinocrassuloside XIII), wherein, compound 1 and compound 2, Compound 3 and compound 4, compound ...

Embodiment 3

[0284] The preparation of embodiment 3 tablet

[0285] Take 33g of compound 1 and 2 respectively, add 217g of medicinal starch, mix evenly, use an appropriate amount of starch paste as a binder to granulate, dry, granulate with a granulator, compress into tablets, 250mg per tablet, orally, each time 1 tablet, 2 times a day.

[0286] The preparation of embodiment 3 capsules

[0287] Take 33g of compounds 1 and 2 respectively, add 217g of medicinal starch and mix evenly, use an appropriate amount of starch paste as a binder to granulate, dry, granulate with a granulator, fill capsules, 250mg per capsule, orally, 1 capsule each time capsules, 2 times a day.

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Abstract

The invention discloses application of compounds as shown in formula I or salt thereof and total saponin ingredients containing the compounds in preparing anti-tumor medicines. Researches show that the compounds as shown in the formula I and the total saponin have strong effects on inhibiting proliferation of human hepatocellular carcinoma cells, human gastric carcinoma cells, human colon cancer cells, human breast cancer cells and a melanoma cell strain, and the compounds as shown in the formula I, combined with chemotherapeutic drugs, have excellent attenuating and synergistic effects.

Description

technical field [0001] The present invention relates to a new application of vacao pentacyclic triterpene saponins, in particular to the application of the compounds in the preparation of antitumor drugs, and belongs to the field of medicine. Background technique [0002] Malignant tumors have always been a major disease that needs to be tackled urgently in the medical field. At present, the drug toxicity and adverse reactions of anti-tumor drugs are getting more and more attention. Seeking drugs with less toxic side effects and strong anti-tumor effects will always be a hot spot and focus of tumor research. Plant-derived drugs are still a treasure trove of ideal anti-tumor drug screening. A number of natural compounds with strong anti-tumor activity, such as paclitaxel, camptothecin, and ginsenoside, have been screened out and have good application prospects. my country is a big country in the use of plant-derived medicines and has a long history of application. In the pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/00
CPCA61K35/00A61K31/704A61P1/00A61P1/04A61P1/16A61P15/00A61P17/00A61P35/00A61K2300/00A61K31/337A61K31/513A61K31/675A61K36/36
Inventor 王学勇赵保胜
Owner 王学勇
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