Salinomycin strain

A salinomycin and strain technology, applied in bacteria, microorganisms, biochemical equipment and methods, etc., can solve the problems of high negative mutation rate and resistance saturation, strain viability, weakened sporulation, and lack of space. Good stability, great economic value, and the effect of increasing production
CN104017756AInactive Publication Date: 2014-09-03ZHEJIANG SHENGHUA BIOK BIOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG SHENGHUA BIOK BIOLOGY
Publication Date
2014-09-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a salinomycin strain with the class name of streptomycesalbums S-610-11, and the preservation number is CCTCCM2012492. The salinomycin high-yielding strain streptomycesalbums S-610-11 is obtained by combination of plasma mutagenesis at normal temperature under normal pressure with high-throughput synergy screening method, the content of salinomycin can be greatly improved, and the stability is good, after 5 times of continuous passages of the strain, and the salinomycin titer has no obvious change. By use of shake flask fermentation, the yield of salinomycin reaches 56000u / ml, and is improved by 70% compared with that of original strain F2-1#. The salinomycin strain is fully consistent with mutagenesis and screening requirements of industrialization salinomycin production strains, and can be applied in industrial fermentation production, and has great economic value.
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Description

technical field

[0001] The invention relates to the field of screening and application of industrial strains, in particular to a salinomycin strain. Background technique

[0002] Salinomycin is one of the main veterinary antibiotics produced, used and exported in my country. It can effectively kill various coccidia in poultry and is widely used in feed additives. It is an ideal anticoccidiostat and feed additive. It is a group of Streptomyces albicans ( Streptomyces albums ) produced monocarboxylic acid polyether is a special antibiotic for animals, which has a strong inhibitory and killing effect on most Gram-positive bacteria (including mycobacteria and some filamentous fungi) and various coccidia. Salinomycin is an anticoccidial agent approved by the US FDA and has been widely used in countries all over the world.

[0003] Salinomycin is a typical ionophore antibiotic, it has positive effects on cations in cells, especially K + 、Na + , Rb + The affinity of cations is...

Claims

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