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A kind of Panax notoginseng wall breaking preparation

A preparation technology of notoginseng, which is applied in the field of traditional Chinese medicine, can solve the problems of loss of active ingredients, easy moisture absorption, increase in powder specific surface area, etc., and achieves the effects of being easy to drink with warm water, easy to disintegrate and disperse, and improving the utilization rate

Active Publication Date: 2018-07-17
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its active ingredients are tetracyclic triterpenes: ginsenoside Rb 1 , Rd, Re, Rg 1 , Rg 2 、Rh 1 , notoginsenoside R 1 , R 2 , R 3 , R 5 , R 6 , R 7 , aescin, notoginseng saponins A, B, C, D, etc.; also contains notoginseng, quercetin and polysaccharides, etc., using traditional decoction methods, it is easy to destroy its heat-sensitive components, on the other hand, decocting active ingredients Cooking is not complete, resulting in the loss of active ingredients
The preparation of Panax notoginseng into superfine powder is conducive to improving the utilization rate of active ingredients, but at the same time, due to the increase in the specific surface area of ​​the powder, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • A kind of Panax notoginseng wall breaking preparation
  • A kind of Panax notoginseng wall breaking preparation
  • A kind of Panax notoginseng wall breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take the medicinal material of notoginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm, add ethanol-water solution (the mass fraction of ethanol is 30 %) Wet process soft materials, the ratio of solution to superfine powder is 0.4︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 85°C, and dried for 2.5 hours until dry.

[0025]

[0026] Note: The full score is 10.

Embodiment 2

[0028] Take the medicinal material of notoginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm, add ethanol-water solution (the mass fraction of ethanol is 50 %) soft material by wet method, the ratio of solution to superfine powder is 0.5︰1 (by weight), after mixing, it is pre-installed with a 10-mesh sieve, and the extrusion speed is 60r / min, and the extrusion force is 0.8MPa. Wet granules, wet granules are transposed into a vacuum microwave drying oven, set the drying temperature at 45°C, and dried for 0.75h until dry.

[0029]

[0030] Note: The full score is 10.

Embodiment 3

[0032] Take the medicinal material of notoginseng, coarsely pulverize it into a coarse powder of about 100 meshes, and then superfinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm, add ethanol-water solution (the mass fraction of ethanol is 90 %) Wet process soft material, the ratio of solution to superfine powder is 0.8︰1 (by weight), after mixing, pre-installed 30 mesh sieve, extrusion speed 80r / min, extrusion force 0.3MPa Wet granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 85°C, and dried for 2.5 hours until dry, and the whole granule is sieved to obtain the Panax notoginseng wall-broken preparation.

[0033]

[0034] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken pseudo-ginseng preparation. The wall-broken pseudo-ginseng preparation is prepared by crushing pseudo-ginseng into ultrafine powder, then carrying out ethanol-water wet granulation, carrying out extrusion forming at a certain rotating speed and then carrying out drying. The prepared wall-broken pseudo-ginseng preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The present invention relates to the field of traditional Chinese medicine, and more specifically relates to a notoginseng wall breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality of the drug in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K9/16A61K36/258A61J3/00
Inventor 成金乐陈勇军徐吉银陈金梅陈玉棠
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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