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Hollow silica submicro-sphere with ferroferric oxide particle and silica core, and preparation method thereof

A technology of ferric oxide and silicon dioxide, which is applied in the direction of iron oxide/ferric hydroxide, medical preparations of non-active ingredients, oxides of sub-ferric iron, etc., can solve the problem of uncontrollable growth space of ferric oxide particles The interior of the cavity and other problems, to achieve high biological stability and biocompatibility, improve the effect of contrast

Inactive Publication Date: 2014-10-01
BEIJING CREATIVE NANOPHASE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the precursor solution of the noble metal inner core is easier to be reduced, and the preparation of the ferric oxide particle inner core needs to be prepared by coprecipitation, the preparation method disclosed in CN201010252663.4 cannot control the growth of ferric oxide particles in the hollow carbon dioxide The interior of the cavity of a silicon submicron sphere

Method used

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  • Hollow silica submicro-sphere with ferroferric oxide particle and silica core, and preparation method thereof
  • Hollow silica submicro-sphere with ferroferric oxide particle and silica core, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The hollow silica submicron sphere with movable spherical silica core can be prepared with reference to CN200610089184.9.

[0031] (1) The specific surface area of ​​the movable spherical silica core with a diameter of 55nm prepared by referring to CN200610089184.9 is 280m 2 / g, a diameter of 310nm, a shell thickness of 21nm, and a hollow silica submicron sphere with an average pore diameter of 3 to 5nm in the mesopores of the shell, soaked in a 1M ferrous ammonium sulfate aqueous solution for 24 hours, Wherein, the mass of the hollow silica submicron sphere with the movable spherical silica inner core accounts for 0.1% of the total mass of the hollow silica submicron sphere with the movable spherical silica inner core and the ferrous ammonium sulfate aqueous solution ; Centrifugation obtains the hollow silica submicron ball with movable spherical silica inner core loaded with ferrous ammonium sulfate;

[0032] (2) Disperse the hollow silica submicron spheres loaded wi...

Embodiment 2

[0035] The hollow silica submicron sphere with movable spherical silica core can be prepared with reference to CN200610089184.9.

[0036] (1) The specific surface area of ​​the movable spherical silica core with a diameter of 540nm prepared by referring to CN200610089184.9 is 460m 2 / g, a diameter of 980nm, a shell thickness of 100nm, and a hollow silicon dioxide submicron sphere with an average pore diameter of 10nm in the mesopores of the shell was immersed in a 2M ammonium ferrous sulfate aqueous solution for 24 hours, wherein, The mass of the hollow silica submicron sphere with the movable spherical silica inner core accounts for 1% of the total mass of the hollow silica submicron sphere with the movable spherical silica inner core and the ferrous ammonium sulfate aqueous solution; centrifugation The hollow silica submicron spheres with movable spherical silica inner core loaded with ammonium ferrous sulfate are separated;

[0037] (2) Disperse the hollow silica submicron...

Embodiment 3

[0040] The hollow silica submicron sphere with movable spherical silica core can be prepared with reference to CN200610089184.9.

[0041] (1) The specific surface area of ​​the movable spherical silica core with a diameter of 50nm prepared by referring to CN200610089184.9 is 140m 2 / g, a diameter of 500nm, a shell thickness of 25nm, and a hollow silica submicron sphere with an average pore diameter of 3 to 5nm in the mesopores of the shell, soaked in an aqueous solution of 1M ferrous ammonium sulfate for 12 hours, Wherein, the mass of the hollow silica submicron sphere with the movable spherical silica inner core accounts for 20% of the total mass of the hollow silica submicron sphere with the movable spherical silica inner core and the ferrous ammonium sulfate aqueous solution ; Centrifugation obtains the hollow silica submicron ball with movable spherical silica inner core loaded with ferrous ammonium sulfate;

[0042] (2) Disperse the hollow silica submicron spheres loaded...

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Abstract

The invention belongs to the technical field of nanocomposites and relates to a hollow silica submicro-sphere with a superparamagnetic ferroferric oxide particle and a silica core and a preparation method thereof. According to the invention, since different solvents have different ferric salt precursor solubility, the precursor of a ferric salt is effectively enclosed in the cavity of the hollow silica submicro-sphere with the movable spherical silica core by using a solvent alternative method, and the superparamagnetic ferroferric oxide particle is generated in the hollow silica submicro-sphere with the movable spherical silica core by using a coprecipitation method. The ferroferric oxide particle in the hollow silica submicro-sphere with the ferroferric oxide particle and the silica core is attached onto the inner surface of the hollow silica submicro-sphere and the surface of the silica core. The hollow silica submicro-sphere provided by the invention can be used as a magnetic resonance imaging contrast agent and a medical drug carrier.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and relates to a hollow silicon dioxide submicron sphere with superparamagnetic iron ferric oxide particles and a silicon dioxide core and a preparation method thereof. Background technique [0002] In recent years, Fe3O4 particles with superparamagnetic properties have attracted much attention in the field of medical imaging. The iron ferric oxide particles with superparamagnetic properties can effectively increase the transverse relaxation time in magnetic resonance imaging and improve the contrast of magnetic resonance imaging. Therefore, in the field of medical imaging, materials with superparamagnetic ferric oxide particles are often used as contrast agents for magnetic resonance imaging. However, because the materials used in the medical field require good biological safety, the applied magnetic resonance imaging contrast agent needs to coat the surface of ferric oxide part...

Claims

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Application Information

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IPC IPC(8): A61K49/06A61K49/08A61K47/04C01G49/08
Inventor 唐芳琼孟宪伟陈东
Owner BEIJING CREATIVE NANOPHASE HI TECH
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