A method for preparing composite granules and quick-release tablet
A technology of composite granules and tablets, which is applied in the directions of pill delivery, pharmaceutical formulations, and food forming to achieve high tablet hardness, excellent stability, and excellent disintegration.
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Examples
Embodiment 1
[0058] To 316 g of purified water were added 8 g of a 10% by weight aqueous solution of polyacrylamide and 60 g of D-mannitol. The resulting mixture was stirred with a paddle to obtain an aqueous solution. Next, 16 g of low-substituted hydroxypropylcellulose having a hydroxypropyl substitution degree of 8% by weight was added to the obtained aqueous solution and mixed to prepare an aqueous dispersion. Then, 323.2g of D-mannitol was put into the fluidized bed granulator, and the temperature of the inlet air was 60°C, the exhaust temperature was 25 to 28°C, the ventilation rate was 50m3 / hr, and the spray rate was 12g / hr. min and a spray pressure of 150 kPa, granulation was performed while spraying the aqueous dispersion thereto.
[0059] After adding 0.5 parts by weight of magnesium stearate as a lubricant to 100 parts by weight of the obtained composite granules and mixing, the resulting mixture was compressed into tablets by using a rotary tablet press at a tableting pressure...
Embodiment 2
[0061]To 324 g of purified water were added 8 g of a 10% by weight aqueous solution of polyacrylamide having a degree of saponification of 98.5 mol % and a degree of polymerization of 1700, and 60 g of D-mannitol. The resulting mixture was stirred with a paddle to obtain an aqueous solution. Next, 8 g of low-substituted hydroxypropylcellulose having a hydroxypropyl substitution degree of 8% by weight was added to the obtained aqueous solution and mixed to prepare an aqueous dispersion. Then, 331.2g of D-mannitol was put into the fluidized bed granulator, and the temperature of the inlet air was 60°C, the exhaust temperature was 25 to 28°C, the ventilation rate was 50m3 / hr, and the spray rate was 12g / hr. min and a spray pressure of 150 kPa, granulation was performed while spraying the aqueous dispersion thereto.
[0062] The composite granules thus obtained were tableted in the same manner as in Example 1 and the tablets thus obtained were also evaluated in the same manner. T...
Embodiment 3
[0064] To 528 g of purified water were added 8 g of a 10% by weight aqueous solution of polyacrylamide having a degree of saponification of 98.5 mol % and a degree of polymerization of 1700, and 60 g of D-mannitol. The resulting mixture was stirred with a paddle to obtain an aqueous solution. Next, 40 g of low-substituted hydroxypropylcellulose having a hydroxypropyl substitution degree of 8% by weight was added to the obtained aqueous solution and mixed to prepare an aqueous dispersion. Then, 299.2g of D-mannitol was put into the fluidized bed granulator, and at an inlet temperature of 60°C, an exhaust temperature of 25 to 28°C, an air flow of 50m3 / hr, and a spray rate of 12g / min and a spray pressure of 150 kPa, granulation was performed while spraying the aqueous dispersion thereto.
[0065] The composite granules thus obtained were tableted in the same manner as in Example 1 and the tablets thus obtained were also evaluated in the same manner. The results are shown in Ta...
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Abstract
Description
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