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Lincomycin Dispersible Tablets

A technology for lincomycin and dispersible tablets, applied in the field of dispersible tablets, can solve the problems of low bioavailability and slow onset of action

Active Publication Date: 2016-08-31
嘉善罗星创业投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings of slow onset of action and low bioavailability of existing lincomycin preparations, the present invention invented lincomycin inclusion compound dispersible tablets

Method used

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  • Lincomycin Dispersible Tablets
  • Lincomycin Dispersible Tablets
  • Lincomycin Dispersible Tablets

Examples

Experimental program
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Embodiment 1

[0030] Lincomycin inclusion complex: lincomycin:γ-cyclodextrin is 2:3.7

[0031] The prescription for dispersible tablets is (by weight):

[0032]

[0033] Preparation:

[0034] 1. Prepare lincomycin inclusion complex according to the following method:

[0035] (1) In a water or aqueous ethanol medium, react lincomycin with γ-cyclodextrin in a certain proportion, filter the obtained solution through a microporous membrane until it becomes clear, and separate the inclusion compound from the mixture; or

[0036] (2) in solid form, reacting lincomycin with γ-cyclodextrin; or

[0037] (3) High-energy grinding by reaction of lincomycin and γ-cyclodextrin.

[0038] 2. Mix the prescription amount of povidone, sodium carboxymethyl cellulose, microcrystalline cellulose, sodium cyclamate and lincomycin inclusion compound in equal amounts, then add magnesium stearate, micropowder silica gel , mixed, and tableted to obtain lincomycin inclusion complex dispersible tablets.

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Abstract

The invention relates to a lincomycin dispersible tablet. Firstly lincomycin is prepared into a clathrate compound, and then the dispersible tablet is prepared.

Description

technical field [0001] The present application relates to a dispersible tablet, in particular, a lincomycin inclusion complex dispersible tablet. Background technique [0002] Lincomycin, English name Lincomycin. Acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the elongation of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Chemical name: 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-6,8-dideoxy-D-erythro-α-D- Galactocaprylopyranoside hydrochloride monohydrate. Lincomycin is a white crystalline powder; it has a slight or special odor; it has a bitter taste. Lincomycin is readily soluble in water or methanol and slightly soluble in ethanol. Lincomycin acts on the 50S subunit of the ribosome of sensitive bacteria, preventing the elongation of the peptide chain, thereby inhibiting the protein synthesis of bacterial cells. Lincomycin is generally a bacteriostatic agent, but at high concentrations, it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7056A61K47/48
Inventor 李淑兰
Owner 嘉善罗星创业投资有限公司
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