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Novel powder-liquid double-chamber infusion bag and preparing method thereof

An infusion bag, a new type of technology, applied in the field of powder-liquid double-chamber infusion bags, can solve the problems of limited use and achieve better barrier properties and convenient hanging

Active Publication Date: 2014-12-10
HUNAN KELUN PHARM RES CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the problems existing in the prior art, the primary purpose of the present invention is to provide a new type of powder-liquid double-chamber infusion bag, which intends to solve the problem of limited use of the existing powder-liquid double-chamber bag products due to the defects of the film material itself

Method used

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  • Novel powder-liquid double-chamber infusion bag and preparing method thereof
  • Novel powder-liquid double-chamber infusion bag and preparing method thereof
  • Novel powder-liquid double-chamber infusion bag and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] One of the preparation methods of the new powder-liquid double-chamber infusion bag (two-layer co-extrusion film material):

[0043] Step 1) The molten polypropylene pellets and the molten polyethylene pellets are made respectively by two pellet extruders, and the molten polypropylene pellets and the molten polyethylene pellets are merged in the co-extrusion equipment and then formed by the inner layer The shunt channel is co-extruded to form a film material with at least two layers of inner and outer layers, wherein the inner layer of the co-extruded film material is composed of a liquid bag inner layer made of polypropylene and a powder bag inner layer made of polyethylene, and A co-extrusion fusion part is formed at the intersection of the two; the outer layer of the co-extruded film is fed by a single polypropylene pellet extruder, and is extruded from the outer layer of the co-extrusion equipment. Determines the number of layers for the outer layer (refer to imag...

Embodiment 2

[0052] The second preparation method of the new powder-liquid double-chamber infusion bag (three-layer co-extrusion film material):

[0053] The difference between the second method and the first method is that the co-extruded film material adopts three layers, and a pellet extruder is added to extrude the molten pellets in the middle layer of polypropylene. The outer layer of the co-extrusion film is made of modified polypropylene middle layer and modified polypropylene outer layer, and the inner layer of co-extrusion film is made of modified polypropylene liquid bag inner layer and polyethylene The inner layer of the powder bag is formed, and a co-extrusion fusion part is formed at the intersection of the two; (refer to Figure 5 ).

[0054] The prepared powder-liquid double-chamber bagged ceftriaxone sodium / sodium chloride injection samples were placed in an environment of 60°C for accelerated investigation, and samples were taken at 5 days and 10 days respectively to test...

Embodiment 3

[0059] The third preparation method of the new powder-liquid double-chamber infusion bag (five-layer co-extruded film material):

[0060] The difference between the third method and the second method is that the co-extruded film material adopts five layers, and two adhesive layer pellet extruders are added to extrude two layers of adhesive layer molten pellets. The quantity determines the number of layers of the outer layer. The outer layer of the co-extrusion film material consists of two adhesive layers, a middle layer of modified polypropylene and an outer layer of modified polypropylene (refer to Figure 6 ).

[0061] The prepared powder-liquid double-chamber bagged fosfomycin sodium / glucose injection samples were placed in an environment of 60°C for accelerated investigation, and samples were taken at 5 and 10 days respectively. The test results are as follows:

[0062] Table 3 Accelerated study results of fosfomycin sodium for injection

[0063]

[0064] The result...

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Abstract

The invention discloses a novel powder-liquid double-chamber infusion bag. The novel powder-liquid double-chamber infusion bag comprises a powder bag and a liquid bag which are separated through at least one weak welding stick. The wall of the infusion bag is composed of a multi-layer coextrusion film material which is at least provided with an inner layer and an outer layer. The inner layer of the liquid bag is made of polypropylene / modified polypropylene, and the inner layer of the powder bag is made of polyethylene / modified polyethylene. A coextrusion fusing part is arranged at the joint of the inner layer of the liquid bag and the inner layer of the powder bag. The novel powder-liquid double-chamber infusion bag solves the dilemma problem caused when only polyethylene is adopted to serve as the inner layer of a chamber or only polypropylene is adopted to serve as the inner layer of the chamber, a polyethylene / modified polyethylene film is adopted to serve as the inner layer of the powder bag so that the film and powder medicine can be good in consistency, a polypropylene / modified polypropylene film is adopted to serve as the inner layer of the liquid bag needing to be sterilized through a terminal so that the requirement for terminal sterilizing can be met, and when used, the novel powder-liquid double-chamber infusion bag is extruded to make the weak welding stick collapse so that the powder bag and the liquid bag can be communicated with each other, and powder and liquid are mixed without bacteria. The invention further discloses a preparing method of the infusion bag.

Description

technical field [0001] The invention relates to a powder-liquid double-chamber transfusion bag and a preparation method of the powder-liquid double-chamber transfusion bag. Background technique [0002] The powder-liquid double-chamber infusion bag product is a ready-to-use infusion product. The packaging material of this product is the powder-liquid double-chamber infusion bag. An infusion bag made of weakly welded heat seal (can be opened under pressure) to separate the inner space. The two chambers of the infusion bag can be used to fill liquid medicine and sterile powder respectively. Before infusion, the operator only needs to apply a certain pressure to the liquid chamber bag, open the weak welding part to connect the two chambers and shake them evenly, so that the sterile liquid and sterile powder are fully mixed and dissolved, and then the Clinical infusion can be performed after the infusion bag is suspended. Compared with the traditional infusion bag, the powder-...

Claims

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Application Information

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IPC IPC(8): A61J1/10A61J1/14B29C69/00B29C47/06B65B3/04B65B1/04B65B55/02
Inventor 赵栋田洪伍佘佑廷朱朝清胡志凤胡思玉王利春王晶翼
Owner HUNAN KELUN PHARM RES CO LTD
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