Shell iodine composite biomedical film and preparation method thereof

A biomedical and shell iodine technology, which is applied in the field of medical materials, can solve the problems such as the introduction of biological dressings that have not yet been discovered, and achieve superior hemostatic function, improve the speed of chemical reactions, and achieve the effects of safe clinical use

Active Publication Date: 2016-06-08
ZHEJIANG SANCHUANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many manufacturers at home and abroad have launched silver-containing dressings, but no functional biological dressings containing shell iodine have been found.

Method used

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  • Shell iodine composite biomedical film and preparation method thereof
  • Shell iodine composite biomedical film and preparation method thereof
  • Shell iodine composite biomedical film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] 1. The chitosan polyvinyl alcohol foam layer is composed of gelatin, chitosan and polyvinyl alcohol, and is prepared according to the following steps:

[0071] Ⅰ. Prepare a 1.0wt% gelatin solution, and heat it in a water bath at 50°C until it is completely dissolved;

[0072] Ⅱ. Add 1.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0073] Ⅲ. Add 0.6wt% chitosan, heat until completely dissolved

[0074] Ⅳ. Add 1.0wt% foaming agent and stir for 1 hour at a speed above 1000r / min;

[0075] Ⅴ. Add 0.8wt% glycerol and mix well;

[0076] Ⅵ. Add 0.01wt% glutaraldehyde and mix thoroughly;

[0077] Ⅶ. Gained chitosan polyvinyl alcohol foam is spread flat on a tetrafluoroethylene plate, and vacuum freeze-dried;

[0078] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0079] Shell iodine, polyvin...

Embodiment 2

[0095] 1. The chitosan polyvinyl alcohol foam layer is made up of gelatin, chitosan and polyvinyl alcohol, and is prepared as follows:

[0096] Ⅰ. Prepare a 3.0wt% gelatin solution, and heat it in a water bath at 50°C until it is completely dissolved;

[0097] Ⅱ. Add 5.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0098] Ⅲ. Add 0.8wt% chitosan, heat until completely dissolved

[0099] Ⅳ. Add 3.0wt% foaming agent and stir for 1 hour at a speed above 1000r / min;

[0100] Ⅴ. Add 2.0wt% glycerin and mix thoroughly;

[0101] Ⅵ. Add 0.1wt% glutaraldehyde and mix thoroughly;

[0102] Ⅶ. spread the obtained chitosan polyvinyl alcohol foam 0.3mm thick on the tetrafluoroethylene plate, vacuum freeze-drying;

[0103] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0104] Shell iodine, polyvinyl alcoho...

Embodiment 3

[0120] The shell iodine composite biomedical film (i.e. shell iodine polyvinyl alcohol-polyvinyl alcohol-chitosan polyvinyl alcohol foam-polyglutamic acid reticular gel composite material) was prepared, and tested by the experimental group of 30 cases of Chengdu Military Region General Hospital. The clinical trial with 30 cases of control groups proves that the shell iodine composite biomedical film with the shell iodine polyvinyl alcohol layer and the gel layer as the matrix provided by the present invention is used for wound dressings such as trauma wounds, surgical wounds, and burn wounds. Compared with the product prepared with application number 201310010441.5, it has more functions of protecting wound surface, absorbing exudate, hemostasis, preventing and controlling wound infection, and promoting wound healing, etc. It is safe and effective in clinical use.

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Abstract

A shell-iodine composite biomedical film, which is composed of shell iodine polyvinyl alcohol layer, polyvinyl alcohol layer, chitosan polyvinyl alcohol foam layer and hydrophilic polyglutamic acid network gel layer, chitosan The polyvinyl alcohol foam layer is compounded between the polyvinyl alcohol layer and the hydrophilic polyglutamic acid network gel layer. Each of the four layers has different effects. The shell iodine polyvinyl alcohol layer has the functions of antibacterial, moisturizing and promoting healing; the polyvinyl alcohol layer has the functions of moisturizing and promoting healing; Liquid and moisturizing effect; the hydrophilic polyglutamic acid mesh gel layer plays the role of hemostasis, absorbing wounds, absorbing exudate and converting it to the chitosan polyvinyl alcohol foam layer. The shell iodine composite biomedical film of the present invention, the shell iodine polyvinyl alcohol layer and the polyvinyl alcohol layer are heated by microwave, which can quickly heat the polar medium, quickly reach the reaction temperature, and shorten the reaction time, and the chitosan polyvinyl alcohol foam layer Dry by vacuum freeze-drying method.

Description

[0001] This application is a divisional application based on the original application with an application date of July 2, 2013, an application number of 201310278304.X, and an invention titled "Shell Iodine Composite Biomedical Film and Its Preparation Method". technical field [0002] The invention belongs to the field of medical materials, and relates to an iodine-shell (antibacterial) wet biocomposite functional dressing, in particular to an improved product of the second part of an iodine-shell composite biomedical film (paste) and a preparation method thereof. Background technique [0003] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. With the aging of the population and the increase of chronic ulcer wounds, the biomaterials closely related to wound repair involve various dressings and coverings on the wound s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/26A61L15/32A61L15/44C08J5/18
Inventor 杨玉民
Owner ZHEJIANG SANCHUANG BIOTECH
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