A kind of method for determining cyclic dipeptide in liquor

A cyclic dipeptide and liquor technology, applied in the field of chemical analysis, can solve the problems of many flavor substances, difficult to separate, false positives of qualitative unknowns, etc., and achieve the effect of saving procedures, saving costs and high accuracy
CN104198641BActive Publication Date: 2016-06-01WULIANGYE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WULIANGYE
Publication Date
2016-06-01

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Abstract

The invention relates to a method for testing cyclic dipeptide in white spirits. The method comprises the following steps: a, taking a white spirits sample, eluting with methanol after passing through an SPE-C18 column, and concentrating an eluent to 1 / 50-1 / 10 of the original volume of the white spirits sample at a temperature not higher than 60 DEG C to obtain a to-be-tested sample; b, loading the sample to be tested in step a to a liquid chromatograph-mass spectrometer, and after mass spectrum full-iron scanning, primarily obtaining possibly existing cyclic dipeptide through full-iron scanning peaks; c, then loading the sample to be tested in step a to the liquid chromatograph-mass spectrometer, and obtaining the characteristic ion peak of each possibly existing cyclic dipeptide after selected iron detection; d, further verifying whether the cyclic dipeptide obtained in step b exists in the white spirits or not according to the characteristic ion peak obtained in step c, and finally making a conclusion. The variety of the cyclic dipeptide in the white spirits sample can be accurately and rapidly tested by the method, and one more effective method is provided for the detection of the cyclic dipeptide in the white spirits.
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Description

technical field

[0001] The invention belongs to the technical field of chemical analysis, in particular to a method for measuring cyclic dipeptides in liquor. Background technique

[0002] Cyclic dipeptides, also known as 2,5-diketopiperazine derivatives, are found in humans, vertebrates, invertebrates, plants, fungi and bacteria. Since the cyclic dipeptide forms a stable six-membered ring structure with certain conformational constraints, there are two hydrogen bond donors and two hydrogen bond acceptors. Hydrogen bonds are one of the main ways for drugs to interact with receptors. Cyclic dipeptides are thus an important pharmacophore in medicinal chemistry. Many cyclic dipeptides have been found to have strong physiological activities, which have attracted widespread interest from organic chemists, biologists and pharmacologists. There are not many reports on cyclic dipeptides, and no reports about cyclic dipeptides in liquor have been found so far.

[0003] Liquor is t...

Claims

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