Idarubicin liposome and preparation method thereof

A technology of idarubicin and star fat is applied in the field of idarubicin liposome and its preparation to achieve the effects of improving clinical curative effect, simple process and reducing toxic effect

Inactive Publication Date: 2014-12-17
深圳市为泰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no domestic research reports and patents on idarubicin liposomes

Method used

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  • Idarubicin liposome and preparation method thereof
  • Idarubicin liposome and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0032] Weigh soybean lecithin and cholesterol for injection according to the weight ratio of 2:1, and dissolve them in an appropriate amount of chloroform to obtain a lipid solution. Transfer this solution to an eggplant-shaped flask, and use a rotary evaporator to evaporate the solvent under reduced pressure in a constant temperature water bath at 37°C, so that the lipid components form a uniform lipid film on the inner wall of the flask, and then drain it. Place it in a vacuum desiccator and place it at room temperature for 24 hours for later use. In addition, 10 mg of idarubicin hydrochloride was accurately weighed and dissolved in an appropriate amount of pH 5.8 phosphate buffer so that the concentration of idarubicin was 1 mg / ml. Add the drug-containing buffer solution to the above-mentioned lipid film to fully swell the lipid film, and wash the film with rotation at 37° C. until the lipid film is hydrated and becomes an orange-red liposome coarse suspension. The coarse ...

Embodiment 2

[0034] Preparation method is the same as embodiment one, wherein:

[0035] Phospholipids: Cholesterol

Embodiment 3

[0037] Preparation method is the same as embodiment one, wherein:

[0038] Phospholipids: Cholesterol

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses an idarubicin liposome and a preparation method thereof. The preparation method reduces the side and toxic effect of idarubicin, and improves the clinical effect. The idarubicin liposome is prepared by the following steps: mixing idarubicin, phosphatide, and cholesterol according to a certain ratio, and then making the mixture into idarubicin liposome through a film dispersion-ultrasonic extrusion combined method. The preparation method has the advantages of simple technology, high encapsulation rate, and suitability for massive production.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to an idarubicin liposome and a preparation method thereof. Background technique: [0002] As a drug carrier, liposome has the characteristics of targeting, high efficiency, low toxicity, sustained release and resistance to drug resistance, and is widely used in many fields such as drug delivery, gene therapy, immunity, diagnostic reagents, cosmetics and pesticides. Idarubicin (IDA) is the first-line drug recommended by the FDA for the treatment of adult acute myeloid leukemia, but its common side effects of myelosuppression greatly limit its wide clinical application. Utilizing the unique advantages of liposome as a carrier, the present invention makes IDA into a liposome preparation in order to reduce drug toxicity and realize targeted drug delivery. In order to improve the stability of the liposome preparation, it was finally prepared into IDA lip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/02A61K31/704A61K9/127
Inventor 杜雨霏
Owner 深圳市为泰医药科技有限公司
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