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Preparation method of cow-bezoar detoxicating tablet

A technology for Niuhuangjiedu tablets and borneol, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It is well controlled and affects the pharmacological effects of traditional Chinese medicines, so as to avoid piebald and splinter, reduce volatilization and improve stability.

Inactive Publication Date: 2014-12-17
JIANGXI JIUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the traditional preparation method, the volatile components in the ice prescription have not been well controlled. According to relevant reports, the loss rate of borneol in the traditional preparation is 20% to 30%, which affects the pharmacological effects of traditional Chinese medicine to some extent. Therefore, the research on how to reduce volatile components is imminent
[0004] Simultaneously, the production method of existing Niuhuangjiedu tablets is to produce tablet cores and then coat film coatings. Due to the volatile borneol, many small holes are prone to appear on the surface of the tablets, which seriously affects the appearance quality of the finished product and the firmness of the coating layer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of preparation method of Niuhuangjiedu tablet is characterized in that, it is prepared by adopting the following process steps:

[0034] 1) Weigh 18.5g of β-cyclodextrin saturated solution, lower the temperature to 25°C, slowly add 25g of borneol dissolved in ethanol dropwise, stir at 20°C for 0.5 hours, then put it in the refrigerator for 24 hours, wash with a small amount of distilled water, Wash off part of the unincluded β-cyclodextrin, dry in vacuum at low temperature for 24 hours, grind, pass through an 80-mesh sieve, wash with ethyl acetate for 3 times, and then dry to obtain white loose borneol, which is ready for use;

[0035] 2), take 200g of rhubarb powder that has been sterilized and cross a 100 mesh sieve, and 5g of artificial bezoar powder that crosses an 80 mesh sieve for subsequent use;

[0036] 3) Take 50g of realgar, add water and grind it into a 0.2-0.3kg / L slurry, freeze-dry to obtain realgar fine powder, and set aside;

[0037] 4) Take 100g ...

Embodiment 2

[0042] A kind of preparation method of Niuhuangjiedu tablet is characterized in that, it is prepared by adopting the following process steps:

[0043] 1) Weigh 18.5g of β-cyclodextrin saturated solution, lower the temperature to 30°C, slowly add 25g of borneol dissolved in ethanol dropwise, stir at 20°C for 1 hour, then put it in the refrigerator for 24 hours, wash with a small amount of distilled water, wash Remove part of the unincluded β-cyclodextrin, dry in vacuum at low temperature for 24 hours, grind, pass through an 80-mesh sieve, wash with ethyl acetate for 3 times, and then dry to obtain white loose borneol, which is ready for use;

[0044] 2), take 200g of rhubarb powder that has been sterilized and cross a 100 mesh sieve, and 5g of artificial bezoar powder that crosses an 80 mesh sieve for subsequent use;

[0045] 3) Take 50g of realgar, add water and grind it into a 0.2-0.3kg / L slurry, freeze-dry to obtain realgar fine powder, and set aside;

[0046] 4) Take 100g ...

Embodiment 3

[0051] A kind of preparation method of Niuhuangjiedu tablet is characterized in that, it is prepared by adopting the following process steps:

[0052] 1) Weigh 18.5g of β-cyclodextrin saturated solution, lower the temperature to 25-35°C, slowly add 25g of borneol dissolved in ethanol dropwise, stir at 25°C for 1.5 hours, then put it in the refrigerator for 24 hours, and add a small amount of distilled water Wash, wash away part of the unincluded β-cyclodextrin, dry in vacuum at low temperature for 24 hours, grind, pass through a 80-mesh sieve, wash with ethyl acetate for 3 times, and then dry to obtain white loose borneol, which is ready for use ;

[0053] 2), take 200g of rhubarb powder that has been sterilized and cross a 100 mesh sieve, and 5g of artificial bezoar powder that crosses an 80 mesh sieve for subsequent use;

[0054] 3) Take 50g of realgar, add water and grind it into a 0.2-0.3kg / L slurry, freeze-dry to obtain realgar fine powder, and set aside;

[0055] 4) Ta...

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Abstract

The invention discloses a preparation method of a cow-bezoar detoxicating tablet. The preparation method comprises the following steps: including borneol with a beta-cyclodextrin saturated solution, adding to powder or paste formed by processing other several medicinal materials, tabletting, adopting 65-75% ethanol, wherein a ratio of the ethanol to the solid content of material liquid of the cow-bezoar detoxicating tablet is 1: (7-9), and controlling air inlet temperature at 70-75 DEG C and material liquid flow at 130-160mL / min. Through the preparation method of the cow-bezoar detoxicating tablet, comprising borneol inclusion through the beta-cyclodextrin saturated solution and subsequent coating treatment, volatilization of active ingredients in borneol is relieved so that the curative effect of medicines can be given a full play, no spot or crack is generated during a tabletting or coating process, and thus a coating yield is more than 97%.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of Niuhuang Jiedu Tablets. Background technique [0002] Niuhuang Jiedu Tablets is a representative medicine for clearing away heat and detoxifying in TCM clinics, and it is developed from the classic prescription Niuhuang Jiedu Pills. It is composed of 8 traditional Chinese medicines of bezoar, rhubarb, baicalin, platycodon, gypsum, realgar, borneol, and licorice. The main function is to clear away heat and detoxify. It is used for internal heat, sore throat, swollen gums, sore mouth and tongue, red and swollen eyes; it is a blindly Chinese patent medicine widely used in clinical practice. [0003] In the traditional preparation method, the volatile components in the ice prescription have not been well controlled. According to relevant reports, the loss rate of borneol in the traditional preparation is 20% to 30%, which affects the pharmacological effects of traditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/28A61K47/48A61P29/00A61K35/413A61K33/36A61K33/06A61K31/045
Inventor 任国权许继石许明景
Owner JIANGXI JIUHUA PHARMA
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