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Thiamphenicol enteric-coated tablets

A technology of thiamphenicol and enteric-coated tablets, applied in the field of enteric-coated tablets, can solve the problems of low bioavailability and poor targeting

Inactive Publication Date: 2016-08-31
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of low bioavailability and poor targeting of existing thiamphenicol preparations, the present invention invented thiamphenicol inclusion compound enteric-coated tablets

Method used

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  • Thiamphenicol enteric-coated tablets
  • Thiamphenicol enteric-coated tablets
  • Thiamphenicol enteric-coated tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Prescription

[0030] Thiamphenicol inclusion compound: thiamphenicol:α-cyclodextrin is 1.5:4.2

[0031] The application provides an enteric-coated tablet of thiamphenicol, which includes:

[0032] Prescription of thiamphenicol inclusion compound tablet core:

[0033] Thiamphenicol inclusion complex

150 copies

Mannitol

180 copies

Starch slurry (10%)

25 copies

hypromellose

10 copies

disintegrant

14.5 servings

Magnesium stearate

8 servings

[0034] Enteric coating prescription:

[0035] Polyvinyl phthalate

25 copies

Cellulose acetate trimellitate

60 copies

85% ethanol

Appropriate amount

talcum powder

15 copies

[0036] Wherein the disintegrant is a composition of hydroxypropyl starch and sodium alginate, and the weight ratio of the two is 3.5:11

[0037] Preparation:

[0038] 1. Prepare thiamphenicol inclusion compound according to the...

Embodiment 2

[0046] Thoroughly grind the thiamphenicol and α-cyclodextrin described in Example 1 in 50% ethanol until a uniform paste is formed. After vacuum drying, a white powder is obtained. The solubility of the powder in water is lower than that of unincluded methylsulfone Mycin increased by 13 times.

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PUM

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Abstract

The application relates to a thiamphenicol enteric-coated tablet. The thiamphenicol is firstly prepared into an inclusion compound, and then prepared into an enteric-coated tablet.

Description

technical field [0001] The present application relates to an enteric-coated tablet, specifically, a thiamphenicol inclusion compound enteric-coated tablet. Background technique [0002] Thiamphenicol English / Latin name: Thiamphenicol, alias thiamphenicol, thiamphenicol chloramphenicol. This product is white crystalline powder; odorless. [0003] Thiamphenicol is a synthetic broad-spectrum antibiotic and a substitute for chloramphenicol. Its antibacterial effect in vivo is stronger than that of chloramphenicol, but its toxicity is less than that of chloramphenicol. Thiamphenicol has poor water solubility, and its dosage form and clinical application are limited. [0004] Thiamphenicol acts by inhibiting bacterial protein synthesis, mainly reversibly binding to the 50s subunit of the bacterial 70s ribosome, inhibiting peptidyltransferase, thereby specifically preventing aminoacyl-tRNA from interacting with the ribosome Receptor binding inhibits the elongation of the peptide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K47/40A61K31/165A61P31/04
Inventor 李娜董鑫钟加腾焦军杰于小佳牛胜慧
Owner XINXIANG MEDICAL UNIV