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Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel

A technology of hydroxyapatite and polyacrylamide, which is applied in the field of polymer materials, can solve the problems of lack of energy dissipation mechanism, low mechanical strength, low ductility, etc., and achieves enhanced mechanical properties, enhanced mechanical properties, and enhanced compression mechanics. performance effect

Inactive Publication Date: 2014-12-24
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the general hydrogel lacks an effective energy dissipation mechanism due to the widely distributed long chains forming random cross-linking points through traditional covalent cross-linking, so it presents brittleness, low ductility, and low mechanical strength. Very limited, so it is necessary to further improve the mechanical properties of the gel material

Method used

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  • Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel
  • Preparation method of hydroxyapatite/graphene oxide/polyacrylamide composite hydrogel

Examples

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Effect test

Embodiment 1

[0023] Example 1: Preparation method of hydroxyapatite / graphene oxide / polyacrylamide composite hydrogel

[0024] (1) Preparation of hydroxyapatite (HA) aqueous solution: Dissolve 0.1g hydroxyapatite (HA) powder of 12μm in 5mL secondary water, shake and stir to fully dissolve, and obtain 0.02g / mL hydroxyapatite (HA) powder Milky white HA solution;

[0025] (2) Preparation of graphene oxide (GO) aqueous solution: Dissolve 0.01g of graphene oxide (GO) powder in 5mL of secondary water, then vibrate and stir to dissolve fully and quickly, and then obtain black translucent GO with a concentration of 0.002g / mL solution;

[0026] (3) Preparation of crosslinking agent aqueous solution (MBA): Dissolve 0.02g of crosslinking agent N,N'-methylenebisacrylamide (MBA) in 5mL of secondary water, and ultrasonically oscillate for 2 minutes to disperse the solution evenly, and then obtain the concentration 0.004g / mL crosslinking agent aqueous solution;

[0027] (4) Preparation of initiator a...

Embodiment 2

[0041] Example 2: Preparation method of hydroxyapatite / graphene oxide / polyacrylamide composite hydrogel

[0042] (1) Preparation of hydroxyapatite (HA) aqueous solution: Dissolve 0.2g of 12μm hydroxyapatite (HA) powder in 10mL of secondary water, and oscillate and stir to fully dissolve, that is, the concentration of 0.02g / mL Milky white HA solution;

[0043] (2) Preparation of graphene oxide (GO) aqueous solution: Dissolve 0.02g of graphene oxide (GO) powder in 10mL of secondary water, then shake and stir to fully dissolve, and obtain a black and transparent GO solution with a concentration of 0.002g / mL ;

[0044] (3) Preparation of crosslinking agent aqueous solution (MBA): Dissolve 0.04g of crosslinking agent N,N'-methylenebisacrylamide (MBA) in 10mL of secondary water, and ultrasonically oscillate for 2 minutes to disperse the solution evenly, and obtain the concentration 0.004g / mL crosslinking agent aqueous solution;

[0045] (4) Preparation of initiator aqueous solu...

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Abstract

The invention discloses a preparation method of hydroxyapatite (HA) / graphene oxide (GO) / polyacrylamide (PAM) composite hydrogel, and belongs to the field of high polymer materials. Hydroxyapatite (HA) and graphene oxide (GO) are prepared into a solution, and then are doped into a polyacrylamide (PAM) network structure. According to the method, the preparation process is simple and convenient to operate, the cost is saved, the problems that a polyacrylamide (PAM) bracket easily bends and the mechanical property is poor are overcome by the obtained composite material, and the characteristics that the graphene oxide (GO) is relatively low in cytotoxicity, and strong in drug-loading capacity, and the hydroxyapatite (HA) is good in biocompatibility are reserved. Therefore, the composite material can be used as a bone repair material, and has potential application value in tissue engineering.

Description

technical field [0001] The invention relates to a preparation method of hydroxyapatite / graphene oxide / polyacrylamide composite hydrogel, which belongs to the technical field of polymer materials. Background technique [0002] Due to its good biocompatibility, polyacrylamide (PAM) hydrogel has aroused widespread interest in the biological application community, and the biological application community uses it in the fields of tissue engineering scaffold materials, cartilage tissue replacement materials, drug carriers, etc. ( J. P. Gong, Advanced MateriaLs , 2003, 15, 1155-1158). In particular, hydrogel scaffolds with certain strength have been applied to the research and development of products such as bone, cartilage and muscle. The strength of the hydrogel has a certain relationship with the degree of cross-linking of the gel and its use conditions. However, the general hydrogel lacks an effective energy dissipation mechanism due to the widely distributed long chains form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/56C08F222/38C08F2/44C08K3/32C08K3/04C08J3/075
Inventor 王艳芹武晓刚岑海鹏于维伦郭媛张永刚陈维毅
Owner TAIYUAN UNIV OF TECH
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