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Anti-corrosive and bactericidal agent composition containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether and application of anti-corrosive and bactericidal agent composition

A technology of antiseptic bactericide, hydroxydiphenyl ether, applied in the direction of bactericide, biocide, biocide, etc., to meet the requirements of bactericidal (bactericidal) rate, excellent water solubility, and increased water solubility.

Active Publication Date: 2015-01-07
BEIJING SUNPU BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The invention provides a kind of anticorrosion and fungicide composition containing 2,4,4'-trichloro-2'-hydroxydiphenyl ether, which overcomes the problem of pure product 2,4,4'-trichloro-2'-hydroxydiphenyl ether It is insoluble in water, and through the synergistic effect between components, it can achieve better antibacterial (killing) effect. Users can use it alone or compound with other preservatives according to their own needs, and it can be used in various personal care products conveniently. product formulations, especially those with high water content

Method used

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  • Anti-corrosive and bactericidal agent composition containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether and application of anti-corrosive and bactericidal agent composition
  • Anti-corrosive and bactericidal agent composition containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether and application of anti-corrosive and bactericidal agent composition
  • Anti-corrosive and bactericidal agent composition containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether and application of anti-corrosive and bactericidal agent composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Table 1. The feeding amount of each formula

[0034]

[0035] In a 150mL three-necked flask with stirring and a thermometer, add solvent, synergist and solubilizing stabilizer according to the dosage of each formulation in Table 1, heat to 50°C under stirring, and then add 2,4,4'- Trichloro-2'-hydroxydiphenyl ether is maintained at about 50°C, stirred to make it fully dissolved, and then lowered to room temperature to obtain a stable antiseptic and fungicide composition. The obtained composition has excellent water solubility and is very easy to use in various occasions.

Embodiment 2

[0037] Observe that 2,4,4'-trichloro-2'-hydroxyl diphenyl ether pure product (≥99%, be called for short TCS), 10% TCS-propylene glycol solution and the partial formula composition of embodiment 1 are at normal temperature (25 ℃) The results are shown in Table 2.

[0038] Table 2. Water Solubility Observations

[0039]

[0040] It can be seen from Table 2 that the composition of the present invention can greatly improve the actual solubility of 2,4,4'-trichloro-2'-hydroxyl diphenyl ether in water, only by simply dissolving in a solvent such as propylene glycol and then adding it to water and Can not significantly improve its solubility. As a kind of antiseptic and fungicide, the relevant laws and regulations at home and abroad stipulate that the maximum amount of it added in cosmetic formulations is 0.1-0.3% depending on the product, and the amount added in some industries can be greater than 1%. It can be seen that the composition proposed by the present invention can ful...

Embodiment 3

[0042] Determination and implementation of pure 2,4,4'-trichloro-2'-hydroxydiphenyl ether (≥99%, referred to as TCS) by plate coating method (for mold, yeast) and dilution culture method (for bacteria) The minimum inhibitory concentration (MIC value) of part formula composition in example 1, the results are shown in Table 3.

[0043] Table 3. Minimum inhibitory concentration (MIC value) (ppm)

[0044]

[0045] As can be seen from Table 3, each formulation composition is compared with pure 2,4,4'-trichloro-2'-hydroxydiphenyl ether, due to the synergistic effect between components, at the equivalent TCS active substance concentration, the The actual antibacterial efficiency of the inventive composition is better than TCS alone.

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Abstract

The invention discloses an anti-corrosive and bactericidal agent composition containing 2,4,4'-trichloro-2'-hydroxyl diphenyl ether and an application of the anti-corrosive and bactericidal agent composition. The anti-corrosive and bactericidal agent composition consists of the following components in percentage by weight: 2,4,4'-trichloro-2'-hydroxyl diphenyl ether which accounts for 1-25% of the total weight of the composition, a solubilization stabilizing agent which accounts for 5-65% of the total weight of the composition, a synergistic agent which accounts for 5-25% of the total weight of the composition and a solvent which accounts for 10-70% of the total weight of the composition. The composition disclosed by the invention is extremely excellent in water solubility, can be used for greatly improving the solubility of 2,4,4'-trichloro-2'-hydroxyl diphenyl ether in water, is excellent in bacteriostatic (bactericidal) ability and stable in performance, can be widely applied to the fields of cosmetics, wet wipes, hand cleaners, household cleaning products, leathers, textiles and the like as an anti-corrosive and bactericidal agent, and can meet the requirements of the bacteriostatic (bactericidal) rate of antibacterial products for bacteria and fungi.

Description

technical field [0001] The present invention relates to an antiseptic and fungicide composition and its application, in particular to a stable bactericide composed of 2,4,4'-trichloro-2'-hydroxydiphenyl ether, a solubilizing stabilizer, a synergist and a solvent. Spectrum antiseptic bactericide composition and application. Background technique [0002] 2,4,4'-Trichloro-2'-hydroxydiphenyl ether is a halogenated o-hydroxydiphenyl ether compound, commonly known as triclosan, the pure product is a white crystalline powder with a melting point of 55-58°C and is easily soluble in Ethanol, isopropanol, acetone, propylene glycol, polyethylene glycol and other organic solvents, insoluble in water. It has a wide range of inhibitory and killing effects on bacteria (Gram-positive, Gram-negative), yeast, mold, viruses and other microorganisms. It is a cosmetic preservative approved for use in many countries and regions such as the European Union, the United States, Japan, and China. an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/16A01N25/30A01N25/02A01P1/00A01P3/00A61K8/33A61P31/02A61Q19/10
Inventor 冯士清高学敏李平刘春霞蔡宏洋
Owner BEIJING SUNPU BIOCHEM TECH
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