Anticoagulant sustain-released capsule, preparation method thereof, and functional anticoagulant sustain-releasing device
A technology of sustained-release capsules and gel materials, applied in the medical field, can solve the problems of increasing the risk of pyrogen reaction, changing the amount of anticoagulant injection, poor convenience, etc., and achieve the effect of preventing the expansion of blood coagulation range
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[0032] The preparation process of the anticoagulant sustained-release capsules comprises the following steps:
[0033] (1) The anticoagulant substances, compounds containing double bonds at both ends (as chemical crosslinking agents) and N-alkylacrylamide monomers are 5% to 30%, 10% to 15%, and 60% by mass percentage Add ~80% of it to sterile water for injection in sequence to prepare an aqueous solution with a mass concentration of 10% to 50%. In a sealed container at 8 to 12°C, nitrogen gas is introduced and stirred for 30 to 70 minutes until a completely dispersed uniform solution is formed. Mix the aqueous solution. Pass the configuration solution into a sealed container at 8-12°C with nitrogen gas to reduce the solubility of oxygen and carbon dioxide gas in the aqueous solution. At the same time, the inert gas nitrogen gas introduced further eliminates the residual oxygen and carbon dioxide in the configuration solution, thereby reducing as much as possible Configure the...
Embodiment 1
[0039] Add 50g of heparin sodium, 25g of methylenebisacrylamide, and 135g of isopropylacrylamide into 1L of sterile water for injection in sequence, and in a sealed container at 10°C, blow in nitrogen gas and stir for 60 minutes until a completely dispersed uniform mixture is formed. Aqueous solution: Cool the above mixed aqueous solution to 1°C, add 1.5g of potassium persulfate after 30min, inject 5mL of N,N,N'N'-tetramethylethylenediamine after 10min, and continue to stir for 15min under nitrogen protection; Immediately pour the reaction solution into the forming mold, seal it and let it stand for reaction at 18°C for 40 hours, then soak it in the aqueous solution of heparin sodium injection with a mass fraction of 5% for 8 hours, and then rinse the reaction product with water for injection for 12 hours to obtain Anticoagulant extended-release capsules. The gel sustained-release capsules are transparent to milky white in appearance, with a volume of 0.05cm 3 .
[0040] W...
Embodiment 2
[0044] Add 10g of heparin calcium, 5g of ethylene glycol dimethacrylate, and 27g of isopropylacrylamide into 200mL of sterilized water for injection in sequence. In a sealed container at 10°C, blow nitrogen into it and stir for 60 minutes until completely dispersed Homogeneous mixed aqueous solution; cool the above mixed aqueous solution to 1°C, add 0.36g ammonium persulfate after 30 minutes, inject 1mL N,N,N'N'-tetramethylethylenediamine after 10 minutes, and continue to stir for 15 minutes under nitrogen protection; The stirred reaction solution was immediately poured into the forming mold, sealed and allowed to stand for reaction at 18°C for 40 hours, then immersed in 40% heparin calcium aqueous solution for injection for 8 hours, and then the reaction product was rinsed with water for injection for 12 hours. The anticoagulant sustained-release capsules are obtained. The appearance of the gel sustained-release capsule is transparent to milky white, and the volume is 0.1cm...
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